RPMI-7951 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description Human skin malignant melanoma cells that can be ordered from ATCC. This is a hyperdiploid human cell line with the modal chromosome number of 49, occurring in 24% of cells. Polyploid cells occurred at 22%, which is high. Cells are adherent, and were first harvested in 1971 from a metastatic site in a lymph node. (Experimental Factor Ontology, EFO_0005712)
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Genes

188 genes with high or low expression in RPMI-7951 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
FMO3 flavin containing monooxygenase 3 3.15821
DPT dermatopontin 2.92539
HAB1 B1 for mucin 2.61619
FAP fibroblast activation protein, alpha 2.56227
BGLAP bone gamma-carboxyglutamate (gla) protein 2.52423
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 2.45098
CMKLR1 chemerin chemokine-like receptor 1 2.33228
COLEC12 collectin sub-family member 12 2.127
FBP2 fructose-1,6-bisphosphatase 2 2.11602
VIPR1 vasoactive intestinal peptide receptor 1 2.11582
ACOT7 acyl-CoA thioesterase 7 2.09452
RSU1 Ras suppressor protein 1 2.0745
FMO1 flavin containing monooxygenase 1 2.07253
OR2C1 olfactory receptor, family 2, subfamily C, member 1 2.06107
NTF3 neurotrophin 3 2.02791
SNED1 sushi, nidogen and EGF-like domains 1 2.00589
NRP1 neuropilin 1 1.99234
LRRC32 leucine rich repeat containing 32 1.98945
WISP1 WNT1 inducible signaling pathway protein 1 1.96368
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 1.96276
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 1.92717
EHD4 EH-domain containing 4 1.80719
LIMD1 LIM domains containing 1 1.80283
GPR176 G protein-coupled receptor 176 1.79834
COL10A1 collagen, type X, alpha 1 1.79627
TAC1 tachykinin, precursor 1 1.76775
KCNMB2 potassium channel subfamily M regulatory beta subunit 2 1.76522
TRDMT1 tRNA aspartic acid methyltransferase 1 1.74671
GPR39 G protein-coupled receptor 39 1.74625
ADGRL4 adhesion G protein-coupled receptor L4 1.73732
CCDC121 coiled-coil domain containing 121 1.72791
CCDC102B coiled-coil domain containing 102B 1.70954
GP9 glycoprotein IX (platelet) 1.70925
SH3GLB1 SH3-domain GRB2-like endophilin B1 1.70666
PROZ protein Z, vitamin K-dependent plasma glycoprotein 1.69679
SIGLEC15 sialic acid binding Ig-like lectin 15 1.69323
GPKOW G patch domain and KOW motifs 1.69053
ZEB1 zinc finger E-box binding homeobox 1 1.68765
ACYP2 acylphosphatase 2, muscle type 1.68392
CYP2A7P1 cytochrome P450, family 2, subfamily A, polypeptide 7 pseudogene 1 1.6767
CHN1 chimerin 1 1.66012
SRY sex determining region Y 1.64724
ARFRP1 ADP-ribosylation factor related protein 1 1.63515
LRRC15 leucine rich repeat containing 15 1.6334
TMEM43 transmembrane protein 43 1.63197
PTGFR prostaglandin F receptor (FP) 1.60705
TEX13B testis expressed 13B 1.60333
IGLV6-57 immunoglobulin lambda variable 6-57 1.60322
CRYBB3 crystallin, beta B3 1.60236
ANTXR1 anthrax toxin receptor 1 1.59089
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 1.58906
KCNK2 potassium channel, two pore domain subfamily K, member 2 1.58529
HBBP1 hemoglobin, beta pseudogene 1 1.5837
GLB1L galactosidase, beta 1-like 1.58119
CLIC4 chloride intracellular channel 4 1.57782
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 1.57358
CAPZB capping protein (actin filament) muscle Z-line, beta 1.5499
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 1.54776
RARB retinoic acid receptor, beta 1.53997
MRPS22 mitochondrial ribosomal protein S22 1.53776
EHD3 EH-domain containing 3 1.52935
AQP1 aquaporin 1 (Colton blood group) 1.50592
HPCAL1 hippocalcin-like 1 1.50582
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 1.49897
PRPF18 pre-mRNA processing factor 18 1.49784
PRNP prion protein 1.494
TBC1D19 TBC1 domain family, member 19 1.48405
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 1.48132
SH2B3 SH2B adaptor protein 3 1.47824
HUS1 HUS1 checkpoint homolog (S. pombe) 1.47359
PARVA parvin, alpha 1.47051
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 1.46957
GNG11 guanine nucleotide binding protein (G protein), gamma 11 1.46755
CTSK cathepsin K 1.4665
COL5A3 collagen, type V, alpha 3 1.46546
EID1 EP300 interacting inhibitor of differentiation 1 1.46114
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 1.44269
RAB30 RAB30, member RAS oncogene family 1.44249
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 1.44074
SEPT7 septin 7 1.4386
LOC650293 seven transmembrane helix receptor 1.43532
TRGV5 T cell receptor gamma variable 5 1.43413
SPTBN5 spectrin, beta, non-erythrocytic 5 1.42683
THY1 Thy-1 cell surface antigen 1.41888
DPF3 D4, zinc and double PHD fingers, family 3 1.41756

low expression

Symbol Name Standardized Value
BCL2L11 BCL2-like 11 (apoptosis facilitator) -3.38709
SPAG8 sperm associated antigen 8 -2.72645
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -2.53978
LGALS4 lectin, galactoside-binding, soluble, 4 -2.4839
TOP3B topoisomerase (DNA) III beta -2.4746
CEP72 centrosomal protein 72kDa -2.44295
FAM49B family with sequence similarity 49, member B -2.35232
KDM6B lysine (K)-specific demethylase 6B -2.28821
ZFHX2 zinc finger homeobox 2 -2.1723
IDE insulin-degrading enzyme -2.03626
CLEC4M C-type lectin domain family 4, member M -2.02627
CPNE7 copine VII -1.98637
SIRT5 sirtuin 5 -1.98364
SNX27 sorting nexin family member 27 -1.97597
LARP1 La ribonucleoprotein domain family, member 1 -1.95841
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 -1.94719
CRY2 cryptochrome circadian clock 2 -1.93984
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 -1.93249
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 -1.9082
SHPK sedoheptulokinase -1.8876
CDK12 cyclin-dependent kinase 12 -1.88428
LRRC37A leucine rich repeat containing 37A -1.88172
HOXD11 homeobox D11 -1.86992
GTPBP1 GTP binding protein 1 -1.86973
DSG2 desmoglein 2 -1.83827
ELMO3 engulfment and cell motility 3 -1.83512
RBM38 RNA binding motif protein 38 -1.83406
AP1G2 adaptor-related protein complex 1, gamma 2 subunit -1.8272
LPA lipoprotein, Lp(a) -1.82453
KRAS Kirsten rat sarcoma viral oncogene homolog -1.81471
LMTK2 lemur tyrosine kinase 2 -1.81209
EXOC6B exocyst complex component 6B -1.80982
SREK1IP1 SREK1-interacting protein 1 -1.78104
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 -1.76973
HMHB1 histocompatibility (minor) HB-1 -1.76733
HPS4 Hermansky-Pudlak syndrome 4 -1.76593
PTP4A3 protein tyrosine phosphatase type IVA, member 3 -1.76302
PON1 paraoxonase 1 -1.76082
ZNF131 zinc finger protein 131 -1.75497
IRF8 interferon regulatory factor 8 -1.75004
IL3 interleukin 3 -1.74643
GPT glutamic-pyruvate transaminase (alanine aminotransferase) -1.73554
FXYD2 FXYD domain containing ion transport regulator 2 -1.7257
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -1.72144
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 -1.71824
HOOK2 hook microtubule-tethering protein 2 -1.71481
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) -1.70764
CAND2 cullin-associated and neddylation-dissociated 2 (putative) -1.70502
UNC93B1 unc-93 homolog B1 (C. elegans) -1.70079
OR7E24 olfactory receptor, family 7, subfamily E, member 24 -1.69047
TAZ tafazzin -1.68549
NPDC1 neural proliferation, differentiation and control, 1 -1.67727
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) -1.67684
KRT31 keratin 31, type I -1.67056
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -1.65946
FBXW4 F-box and WD repeat domain containing 4 -1.64288
HDAC5 histone deacetylase 5 -1.64266
TP53 tumor protein p53 -1.64192
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -1.62281
PWWP2A PWWP domain containing 2A -1.61958
KRT20 keratin 20, type I -1.6193
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) -1.61135
PRRC2C proline-rich coiled-coil 2C -1.61072
DCAF7 DDB1 and CUL4 associated factor 7 -1.60991
AQP4 aquaporin 4 -1.6095
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) -1.60606
SMAD9 SMAD family member 9 -1.60587
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein -1.60243
KLC2 kinesin light chain 2 -1.60133
AUTS2 autism susceptibility candidate 2 -1.58861
CAMSAP1 calmodulin regulated spectrin-associated protein 1 -1.56635
NT5C2 5'-nucleotidase, cytosolic II -1.56561
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) -1.55971
DICER1 dicer 1, ribonuclease type III -1.55243
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4 -1.5478
KLK13 kallikrein-related peptidase 13 -1.54557
PPP1R13B protein phosphatase 1, regulatory subunit 13B -1.54467
RHOF ras homolog family member F (in filopodia) -1.54403
LMBR1L limb development membrane protein 1-like -1.5406
FOXK2 forkhead box K2 -1.5383
CPN2 carboxypeptidase N, polypeptide 2 -1.53644
CAPN3 calpain 3, (p94) -1.5321
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -1.52769
HIST1H3B histone cluster 1, H3b -1.50818
NELFA negative elongation factor complex member A -1.50677
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A -1.48003
TOP3A topoisomerase (DNA) III alpha -1.47668
BRAP BRCA1 associated protein -1.47619
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -1.47596
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) -1.47154
PTEN phosphatase and tensin homolog -1.46813
ZNF263 zinc finger protein 263 -1.46714
LIAS lipoic acid synthetase -1.4609
STATH statherin -1.45132
CDK3 cyclin-dependent kinase 3 -1.44964
ZNF467 zinc finger protein 467 -1.4477
CBX8 chromobox homolog 8 -1.43649
CCDC33 coiled-coil domain containing 33 -1.43216
PRRC2B proline-rich coiled-coil 2B -1.43155
HSPB6 heat shock protein, alpha-crystallin-related, B6 -1.42815
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 -1.4251
CCDC59 coiled-coil domain containing 59 -1.42443
MEP1B meprin A, beta -1.42249