RNF mutants show enhanced WNT signaling and proliferation Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-5340588
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Genes

190 proteins participating in the RNF mutants show enhanced WNT signaling and proliferation pathway from the Reactome Pathways dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AMER1 APC membrane recruitment protein 1
APC adenomatous polyposis coli
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
AXIN1 axin 1
AXIN2 axin 2
BCL9 B-cell CLL/lymphoma 9
BCL9L B-cell CLL/lymphoma 9-like
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CAV1 caveolin 1, caveolae protein, 22kDa
CBY1 chibby homolog 1 (Drosophila)
CCDC88C coiled-coil domain containing 88C
CDC73 cell division cycle 73
CHD8 chromodomain helicase DNA binding protein 8
CREBBP CREB binding protein
CSNK1A1 casein kinase 1, alpha 1
CSNK1E casein kinase 1, epsilon
CSNK1G2 casein kinase 1, gamma 2
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
CTBP1 C-terminal binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
CUL3 cullin 3
CXXC4 CXXC finger protein 4
DACT1 dishevelled-binding antagonist of beta-catenin 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK2 dickkopf WNT signaling pathway inhibitor 2
DKK4 dickkopf WNT signaling pathway inhibitor 4
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
EP300 E1A binding protein p300
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FZD1 frizzled class receptor 1
FZD2 frizzled class receptor 2
FZD4 frizzled class receptor 4
FZD5 frizzled class receptor 5
FZD6 frizzled class receptor 6
FZD8 frizzled class receptor 8
GSK3B glycogen synthase kinase 3 beta
H2AFB1 H2A histone family, member B1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
H2BFS H2B histone family, member S (pseudogene)
H3F3A H3 histone, family 3A
HDAC1 histone deacetylase 1
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HIST1H2AB histone cluster 1, H2ab
HIST1H2AC histone cluster 1, H2ac
HIST1H2AD histone cluster 1, H2ad
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BA histone cluster 1, H2ba
HIST1H2BB histone cluster 1, H2bb
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BH histone cluster 1, H2bh
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BK histone cluster 1, H2bk
HIST1H2BL histone cluster 1, H2bl
HIST1H2BM histone cluster 1, H2bm
HIST1H2BN histone cluster 1, H2bn
HIST1H2BO histone cluster 1, H2bo
HIST1H3A histone cluster 1, H3a
HIST1H4A histone cluster 1, H4a
HIST2H2AA3 histone cluster 2, H2aa3
HIST2H2AC histone cluster 2, H2ac
HIST2H2BE histone cluster 2, H2be
HIST2H3A histone cluster 2, H3a
HIST3H2BB histone cluster 3, H2bb
HIST3H3 histone cluster 3, H3
KAT5 K(lysine) acetyltransferase 5
KLHL12 kelch-like family member 12
KMT2D lysine (K)-specific methyltransferase 2D
KREMEN1 kringle containing transmembrane protein 1
KREMEN2 kringle containing transmembrane protein 2
LEF1 lymphoid enhancer-binding factor 1
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LGR6 leucine-rich repeat containing G protein-coupled receptor 6
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
MEN1 multiple endocrine neoplasia I
MYC v-myc avian myelocytomatosis viral oncogene homolog
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB11 proteasome (prosome, macropain) subunit, beta type, 11
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PSME4 proteasome (prosome, macropain) activator subunit 4
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PYGO1 pygopus family PHD finger 1
PYGO2 pygopus family PHD finger 2
RBBP5 retinoblastoma binding protein 5
RBX1 ring-box 1, E3 ubiquitin protein ligase
RNF146 ring finger protein 146
RNF43 ring finger protein 43
RPS27A ribosomal protein S27a
RSPO1 R-spondin 1
RSPO2 R-spondin 2
RSPO3 R-spondin 3
RSPO4 R-spondin 4
RUVBL1 RuvB-like AAA ATPase 1
RYK receptor-like tyrosine kinase
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOST sclerostin
TCF4 transcription factor 4
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERT telomerase reverse transcriptase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE2 transducin-like enhancer of split 2
TLE3 transducin-like enhancer of split 3
TLE4 transducin-like enhancer of split 4
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRRAP transformation/transcription domain-associated protein
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
USP34 ubiquitin specific peptidase 34
USP8 ubiquitin specific peptidase 8
WIF1 WNT inhibitory factor 1
WNT1 wingless-type MMTV integration site family, member 1
WNT3 wingless-type MMTV integration site family, member 3
WNT3A wingless-type MMTV integration site family, member 3A
WNT4 wingless-type MMTV integration site family, member 4
WNT5A wingless-type MMTV integration site family, member 5A
WNT8A wingless-type MMTV integration site family, member 8A
WNT8B wingless-type MMTV integration site family, member 8B
WNT9A wingless-type MMTV integration site family, member 9A
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPO1 exportin 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNRF3 zinc and ring finger 3