RAD51 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description RAD51 recombinase|The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] (NCBI Entrez Gene Database, 5888)
External Link http://www.ncbi.nlm.nih.gov/gene/5888
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Genes

98 interacting proteins for RAD51 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTB actin, beta
AICDA activation-induced cytidine deaminase
ATM ATM serine/threonine kinase
ATRX alpha thalassemia/mental retardation syndrome X-linked
BARD1 BRCA1 associated RING domain 1
BCCIP BRCA2 and CDKN1A interacting protein
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CAB39 calcium binding protein 39
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CHD3 chromodomain helicase DNA binding protein 3
CHEK1 checkpoint kinase 1
CSNK2A1 casein kinase 2, alpha 1 polypeptide
DMC1 DNA meiotic recombinase 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
E2F1 E2F transcription factor 1
EIF2D eukaryotic translation initiation factor 2D
ERCC2 excision repair cross-complementation group 2
EVL Enah/Vasp-like
FAM175A family with sequence similarity 175, member A
FANCD2 Fanconi anemia, complementation group D2
FBXO18 F-box protein, helicase, 18
FSBP fibrinogen silencer binding protein
H2AFX H2A histone family, member X
HID1 HID1 domain containing
HMG20B high mobility group 20B
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
IRS1 insulin receptor substrate 1
LMNA lamin A/C
MCPH1 microcephalin 1
MDC1 mediator of DNA-damage checkpoint 1
MLF1 myeloid leukemia factor 1
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae)
MORF4L1 mortality factor 4 like 1
MSH2 mutS homolog 2
MSH4 mutS homolog 4
MSH6 mutS homolog 6
NABP2 nucleic acid binding protein 2
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NXF1 nuclear RNA export factor 1
PALB2 partner and localizer of BRCA2
PCNA proliferating cell nuclear antigen
PDS5B PDS5 cohesin associated factor B
PFN1 profilin 1
PLK1 polo-like kinase 1
PML promyelocytic leukemia
POLN polymerase (DNA directed) nu
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
POLR2D polymerase (RNA) II (DNA directed) polypeptide D
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POLR2G polymerase (RNA) II (DNA directed) polypeptide G
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PSMC3IP PSMC3 interacting protein
RAD18 RAD18 E3 ubiquitin protein ligase
RAD51AP1 RAD51 associated protein 1
RAD51AP2 RAD51 associated protein 2
RAD51B RAD51 paralog B
RAD51C RAD51 paralog C
RAD51D RAD51 paralog D
RAD52 RAD52 homolog (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
RBBP8 retinoblastoma binding protein 8
RECQL4 RecQ protein-like 4
RECQL5 RecQ protein-like 5
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
RPA3 replication protein A3, 14kDa
SFR1 SWI5-dependent recombination repair 1
SP1 Sp1 transcription factor
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SWI5 SWI5 recombination repair homolog (yeast)
SWSAP1 SWIM-type zinc finger 7 associated protein 1
TERF2IP telomeric repeat binding factor 2, interacting protein
TEX15 testis expressed 15
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TP53 tumor protein p53
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
UGDH UDP-glucose 6-dehydrogenase
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
UIMC1 ubiquitin interaction motif containing 1
VIM vimentin
WRN Werner syndrome, RecQ helicase-like
XPO1 exportin 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZDHHC17 zinc finger, DHHC-type containing 17