RAD51 Gene Set

Dataset NURSA Protein-Protein Interactions
Category proteomics
Type interacting protein
Description RAD51 recombinase|The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] (NCBI Entrez Gene Database, 5888)
External Link http://www.ncbi.nlm.nih.gov/gene/5888
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Genes

10 interacting proteins for RAD51 from the NURSA Protein-Protein Interactions dataset.

Symbol Name Standardized Value
EIF3C eukaryotic translation initiation factor 3, subunit C 1.50306
CCDC37 coiled-coil domain containing 37 1.06443
PCBP3 poly(rC) binding protein 3 1.06443
HSPA13 heat shock protein 70kDa family, member 13 1.06443
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.380992
DNAH5 dynein, axonemal, heavy chain 5 0.34674
UBQLN4 ubiquilin 4 0.340836
PRPH peripherin 0.314559
JAKMIP2 janus kinase and microtubule interacting protein 2 0.260369
LCN1 lipocalin 1 0.158573