R-atenolol-4259 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the R-atenolol-4259 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACOT11 acyl-CoA thioesterase 11
ADAM20 ADAM metallopeptidase domain 20
AFF2 AF4/FMR2 family, member 2
AGXT alanine-glyoxylate aminotransferase
ARID1A AT rich interactive domain 1A (SWI-like)
ASCL1 achaete-scute family bHLH transcription factor 1
ATP10B ATPase, class V, type 10B
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CD4 CD4 molecule
CD72 CD72 molecule
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC1A C-type lectin domain family 1, member A
CSDC2 cold shock domain containing C2, RNA binding
CSF1 colony stimulating factor 1 (macrophage)
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CST1 cystatin SN
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR6 chemokine (C-X-C motif) receptor 6
DMWD dystrophia myotonica, WD repeat containing
DUOX2 dual oxidase 2
E2F2 E2F transcription factor 2
EBF2 early B-cell factor 2
EPX eosinophil peroxidase
EVI2B ecotropic viral integration site 2B
FAM149A family with sequence similarity 149, member A
FAM174B family with sequence similarity 174, member B
FAM212B family with sequence similarity 212, member B
FGB fibrinogen beta chain
FGF18 fibroblast growth factor 18
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
GBA3 glucosidase, beta, acid 3 (gene/pseudogene)
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRH2 gonadotropin-releasing hormone 2
GPR27 G protein-coupled receptor 27
GRIA3 glutamate receptor, ionotropic, AMPA 3
HAPLN1 hyaluronan and proteoglycan link protein 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXD13 homeobox D13
HRG histidine-rich glycoprotein
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
HYAL4 hyaluronoglucosaminidase 4
IFT140 intraflagellar transport 140
IRF5 interferon regulatory factor 5
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KIF25 kinesin family member 25
KRTAP5-9 keratin associated protein 5-9
MBNL1 muscleblind-like splicing regulator 1
MIER2 mesoderm induction early response 1, family member 2
MUC6 mucin 6, oligomeric mucus/gel-forming
MYH11 myosin, heavy chain 11, smooth muscle
MYH4 myosin, heavy chain 4, skeletal muscle
MYOZ1 myozenin 1
NF1 neurofibromin 1
NHLH2 nescient helix loop helix 2
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
OGG1 8-oxoguanine DNA glycosylase
PACRG PARK2 co-regulated
PAX8 paired box 8
PCDHB17P protocadherin beta 17 pseudogene
PDPN podoplanin
PLEKHS1 pleckstrin homology domain containing, family S member 1
POM121L9P POM121 transmembrane nucleoporin-like 9, pseudogene
POU1F1 POU class 1 homeobox 1
PRDM14 PR domain containing 14
PRRX2 paired related homeobox 2
RBM12B RNA binding motif protein 12B
REPS1 RALBP1 associated Eps domain containing 1
RGR retinal G protein coupled receptor
SCN2B sodium channel, voltage gated, type II beta subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFRP5 secreted frizzled-related protein 5
SLC17A4 solute carrier family 17, member 4
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SNCG synuclein, gamma (breast cancer-specific protein 1)
SPI1 Spi-1 proto-oncogene
SPTBN5 spectrin, beta, non-erythrocytic 5
SRRM2 serine/arginine repetitive matrix 2
ST14 suppression of tumorigenicity 14 (colon carcinoma)
SUSD4 sushi domain containing 4
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TJP3 tight junction protein 3
TRH thyrotropin-releasing hormone
TRPC4 transient receptor potential cation channel, subfamily C, member 4
UTF1 undifferentiated embryonic cell transcription factor 1
VTN vitronectin
ZBTB7A zinc finger and BTB domain containing 7A
ZMAT4 zinc finger, matrin-type 4
ZNF208 zinc finger protein 208
ZNF407 zinc finger protein 407
ZNF747 zinc finger protein 747

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ABHD17B abhydrolase domain containing 17B
ADTRP androgen-dependent TFPI-regulating protein
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AOC2 amine oxidase, copper containing 2 (retina-specific)
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARL14 ADP-ribosylation factor-like 14
ARL15 ADP-ribosylation factor-like 15
ASB7 ankyrin repeat and SOCS box containing 7
ATAD5 ATPase family, AAA domain containing 5
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BGLAP bone gamma-carboxyglutamate (gla) protein
C22ORF29 chromosome 22 open reading frame 29
CCP110 centriolar coiled coil protein 110kDa
CEP112 centrosomal protein 112kDa
CEP295 centrosomal protein 295kDa
CIDEB cell death-inducing DFFA-like effector b
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CNTNAP3B contactin associated protein-like 3B
CSRNP3 cysteine-serine-rich nuclear protein 3
CUZD1 CUB and zona pellucida-like domains 1
CYBRD1 cytochrome b reductase 1
ENDOG endonuclease G
ETNK2 ethanolamine kinase 2
FANCC Fanconi anemia, complementation group C
FER fer (fps/fes related) tyrosine kinase
GMEB1 glucocorticoid modulatory element binding protein 1
GSTCD glutathione S-transferase, C-terminal domain containing
HIST1H4D histone cluster 1, H4d
HOOK1 hook microtubule-tethering protein 1
HOXA1 homeobox A1
HOXC5 homeobox C5
IDI2-AS1 IDI2 antisense RNA 1
IGSF3 immunoglobulin superfamily, member 3
IL17RA interleukin 17 receptor A
INCENP inner centromere protein antigens 135/155kDa
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KIAA1107 KIAA1107
KPNA5 karyopherin alpha 5 (importin alpha 6)
KRT86 keratin 86, type II
LMO7 LIM domain 7
LPPR4 lipid phosphate phosphatase-related protein type 4
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
NDP Norrie disease (pseudoglioma)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PALMD palmdelphin
PARD6A par-6 family cell polarity regulator alpha
PECR peroxisomal trans-2-enoyl-CoA reductase
PGAP1 post-GPI attachment to proteins 1
PGPEP1 pyroglutamyl-peptidase I
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PWAR5 Prader Willi/Angelman region RNA 5
RAI2 retinoic acid induced 2
RC3H2 ring finger and CCCH-type domains 2
RGS17 regulator of G-protein signaling 17
RPH3AL rabphilin 3A-like (without C2 domains)
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAGB Ras-related GTP binding B
SETD8 SET domain containing (lysine methyltransferase) 8
SHROOM2 shroom family member 2
SIX1 SIX homeobox 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLITRK5 SLIT and NTRK-like family, member 5
SLMO1 slowmo homolog 1 (Drosophila)
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPRYD7 SPRY domain containing 7
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TEX15 testis expressed 15
TEX40 testis expressed 40
THBS3 thrombospondin 3
THRAP3 thyroid hormone receptor associated protein 3
TM6SF1 transmembrane 6 superfamily member 1
TMEM242 transmembrane protein 242
TMEM53 transmembrane protein 53
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TSPAN8 tetraspanin 8
TUBA3C tubulin, alpha 3c
TXLNG taxilin gamma
VGF VGF nerve growth factor inducible
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF227 zinc finger protein 227
ZNF34 zinc finger protein 34
ZNF492 zinc finger protein 492
ZNF606 zinc finger protein 606
ZNF675 zinc finger protein 675
ZNF74 zinc finger protein 74
ZNF83 zinc finger protein 83