Purpura Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D011693
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Genes

366 genes/proteins associated with the disease Purpura from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
TNF tumor necrosis factor 2.16718
BAX BCL2-associated X protein 1.94706
IL6 interleukin 6 1.92438
IL1B interleukin 1, beta 1.88753
COL1A1 collagen, type I, alpha 1 1.88327
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.8826
TGFB1 transforming growth factor, beta 1 1.88176
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.87742
VEGFA vascular endothelial growth factor A 1.85625
IGF1 insulin-like growth factor 1 (somatomedin C) 1.84126
BCL2 B-cell CLL/lymphoma 2 1.83717
IL4 interleukin 4 1.82167
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.81665
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.81092
CCL2 chemokine (C-C motif) ligand 2 1.79637
DDIT3 DNA-damage-inducible transcript 3 1.75023
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.74741
CAT catalase 1.74059
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.72302
DUSP1 dual specificity phosphatase 1 1.72116
RB1 retinoblastoma 1 1.7043
MMP3 matrix metallopeptidase 3 1.69721
JUN jun proto-oncogene 1.6947
EGR1 early growth response 1 1.68401
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.67569
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.67355
IFNG interferon, gamma 1.65886
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.65424
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.64955
CTGF connective tissue growth factor 1.64887
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.6482
MAPK3 mitogen-activated protein kinase 3 1.64484
ARC activity-regulated cytoskeleton-associated protein 1.64011
FOS FBJ murine osteosarcoma viral oncogene homolog 1.63765
CCNA2 cyclin A2 1.59101
CDK2 cyclin-dependent kinase 2 1.58065
TP53 tumor protein p53 1.57712
NOS2 nitric oxide synthase 2, inducible 1.56312
MAPK1 mitogen-activated protein kinase 1 1.55182
NOS3 nitric oxide synthase 3 (endothelial cell) 1.54548
CXCL8 chemokine (C-X-C motif) ligand 8 1.53531
BIRC5 baculoviral IAP repeat containing 5 1.5311
RGS4 regulator of G-protein signaling 4 1.52363
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.51961
VCAM1 vascular cell adhesion molecule 1 1.50498
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.49992
BCL2L1 BCL2-like 1 1.49941
CALM1 calmodulin 1 (phosphorylase kinase, delta) 1.49304
BID BH3 interacting domain death agonist 1.48428
CTSB cathepsin B 1.48145
IL1A interleukin 1, alpha 1.4753
ENC1 ectodermal-neural cortex 1 (with BTB domain) 1.46781
ATF3 activating transcription factor 3 1.46462
MPO myeloperoxidase 1.46172
ADORA2A adenosine A2a receptor 1.4612
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.4612
POMC proopiomelanocortin 1.44355
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.43919
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.43892
SRSF1 serine/arginine-rich splicing factor 1 1.43837
MMP2 matrix metallopeptidase 2 1.43809
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.43021
TIMP1 TIMP metallopeptidase inhibitor 1 1.42401
S100A9 S100 calcium binding protein A9 1.42074
PLAT plasminogen activator, tissue 1.41063
GADD45A growth arrest and DNA-damage-inducible, alpha 1.41035
PDGFB platelet-derived growth factor beta polypeptide 1.40953
BAD BCL2-associated agonist of cell death 1.40953
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.4065
FGF2 fibroblast growth factor 2 (basic) 1.40092
CCNB1 cyclin B1 1.39563
PARP1 poly (ADP-ribose) polymerase 1 1.39507
RND3 Rho family GTPase 3 1.39254
SOD1 superoxide dismutase 1, soluble 1.39086
IL10 interleukin 10 1.38441
CFLAR CASP8 and FADD-like apoptosis regulator 1.38327
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) 1.38071
VWF von Willebrand factor 1.37902
COL3A1 collagen, type III, alpha 1 1.37332
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.37332
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.3716
CXCL10 chemokine (C-X-C motif) ligand 10 1.37103
PRKCZ protein kinase C, zeta 1.37103
CCNE1 cyclin E1 1.36677
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.36076
SGK1 serum/glucocorticoid regulated kinase 1 1.36047
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.35962
IL2 interleukin 2 1.35906
F3 coagulation factor III (thromboplastin, tissue factor) 1.35763
ATM ATM serine/threonine kinase 1.34547
NFE2L1 nuclear factor, erythroid 2-like 1 1.34459
HPCAL1 hippocalcin-like 1 1.3443
CD44 CD44 molecule (Indian blood group) 1.34082
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 1.33701
UNG uracil-DNA glycosylase 1.33022
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.32964
EGFR epidermal growth factor receptor 1.32607
GFAP glial fibrillary acidic protein 1.32221
NOS1 nitric oxide synthase 1 (neuronal) 1.31536
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.31416
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.3103
LAMC1 laminin, gamma 1 (formerly LAMB2) 1.30911
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 1.30635
IRF9 interferon regulatory factor 9 1.30512
LDLR low density lipoprotein receptor 1.30329
TOM1 target of myb1 (chicken) 1.29843
DNMBP dynamin binding protein 1.29843
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 1.29812
MBP myelin basic protein 1.29812
CCND1 cyclin D1 1.29688
PTGIS prostaglandin I2 (prostacyclin) synthase 1.2944
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 1.2941
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 1.29225
TOB1 transducer of ERBB2, 1 1.28765
MMP1 matrix metallopeptidase 1 1.28641
JUNB jun B proto-oncogene 1.28395
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.28395
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 1.28241
PON1 paraoxonase 1 1.28027
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.27782
NCOA3 nuclear receptor coactivator 3 1.27751
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.27009
TFRC transferrin receptor 1.267
MCL1 myeloid cell leukemia 1 1.26576
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.26576
ICAM1 intercellular adhesion molecule 1 1.26205
PRKCB protein kinase C, beta 1.26052
THBS1 thrombospondin 1 1.25525
PCNA proliferating cell nuclear antigen 1.25369
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.25276
PCBP1 poly(rC) binding protein 1 1.25214
TGFA transforming growth factor, alpha 1.24997
CDK4 cyclin-dependent kinase 4 1.24874
HSPA1A heat shock 70kDa protein 1A 1.24655
HPCAL4 hippocalcin like 4 1.24623
BMP2K BMP2 inducible kinase 1.24623
HSPB1 heat shock 27kDa protein 1 1.24528
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 1.24496
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.24496
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.24496
WNT5A wingless-type MMTV integration site family, member 5A 1.24433
DNASE1 deoxyribonuclease I 1.24087
TXNIP thioredoxin interacting protein 1.23837
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.23201
CHEK2 checkpoint kinase 2 1.23042
EDNRB endothelin receptor type B 1.23011
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 1.22948
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 1.22948
CCL3 chemokine (C-C motif) ligand 3 1.22916
HSPA1B heat shock 70kDa protein 1B 1.22853
EIF5 eukaryotic translation initiation factor 5 1.2279
SCG2 secretogranin II 1.22469
PLXNB2 plexin B2 1.22436
NUPR1 nuclear protein, transcriptional regulator, 1 1.21919
GAL galanin/GMAP prepropeptide 1.21759
SMAD7 SMAD family member 7 1.21468
IL12A interleukin 12A 1.21304
E2F1 E2F transcription factor 1 1.21304
MAPK14 mitogen-activated protein kinase 14 1.21271
PECAM1 platelet/endothelial cell adhesion molecule 1 1.21239
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 1.20978
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.20848
ADAM19 ADAM metallopeptidase domain 19 1.20394
CDC25A cell division cycle 25A 1.20229
FOSL2 FOS-like antigen 2 1.20229
GATA3 GATA binding protein 3 1.19737
ACE angiotensin I converting enzyme 1.19672
DRD5 dopamine receptor D5 1.19509
YBX3 Y box binding protein 3 1.19477
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.19279
PHGDH phosphoglycerate dehydrogenase 1.19279
PER2 period circadian clock 2 1.19279
FOSL1 FOS-like antigen 1 1.19246
CDC42 cell division cycle 42 1.19047
SCN1B sodium channel, voltage gated, type I beta subunit 1.19014
CX3CL1 chemokine (C-X3-C motif) ligand 1 1.18816
PRKCD protein kinase C, delta 1.18554
FST follistatin 1.18359
GSK3B glycogen synthase kinase 3 beta 1.18159
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.18159
LEP leptin 1.17893
F2 coagulation factor II (thrombin) 1.1786
HMOX1 heme oxygenase 1 1.17827
GNG11 guanine nucleotide binding protein (G protein), gamma 11 1.17695
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 1.17662
CXCL2 chemokine (C-X-C motif) ligand 2 1.17596
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.17497
SPP1 secreted phosphoprotein 1 1.17431
SRSF3 serine/arginine-rich splicing factor 3 1.173
CKB creatine kinase, brain 1.166
CLIC1 chloride intracellular channel 1 1.16467
BTG1 B-cell translocation gene 1, anti-proliferative 1.16401
G0S2 G0/G1 switch 2 1.1617
FOXO1 forkhead box O1 1.1617
BAZ1A bromodomain adjacent to zinc finger domain, 1A 1.1607
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.15899
CALCA calcitonin-related polypeptide alpha 1.15899
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.15763
NLRP3 NLR family, pyrin domain containing 3 1.15695
AGO2 argonaute RISC catalytic component 2 1.15661
IFRD1 interferon-related developmental regulator 1 1.1556
UBE2C ubiquitin-conjugating enzyme E2C 1.15357
SYNE1 spectrin repeat containing, nuclear envelope 1 1.1529
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 1.15256
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 1.15256
MCM6 minichromosome maintenance complex component 6 1.15156
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 1.15156
MKI67 marker of proliferation Ki-67 1.15022
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.14989
HSPA8 heat shock 70kDa protein 8 1.14747
HSPE1 heat shock 10kDa protein 1 1.14747
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 1.14747
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 1.14302
WBP2 WW domain binding protein 2 1.14302
PCDH7 protocadherin 7 1.14166
MMP14 matrix metallopeptidase 14 (membrane-inserted) 1.14132
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.14132
H2AFX H2A histone family, member X 1.1403
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.13758
CBLN1 cerebellin 1 precursor 1.13484
PTN pleiotrophin 1.13484
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 1.13449
CLU clusterin 1.13177
GSTM1 glutathione S-transferase mu 1 1.13143
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 1.13109
CYCS cytochrome c, somatic 1.13075
DHFR dihydrofolate reductase 1.13007
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.12461
EDNRA endothelin receptor type A 1.12288
MDK midkine (neurite growth-promoting factor 2) 1.12151
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.12082
JUND jun D proto-oncogene 1.12082
CES2 carboxylesterase 2 1.12082
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.11741
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.11741
STAR steroidogenic acute regulatory protein 1.11606
MMP9 matrix metallopeptidase 9 1.11571
ALB albumin 1.1129
C10ORF10 chromosome 10 open reading frame 10 1.11151
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.11151
NINJ1 ninjurin 1 1.11081
RGS2 regulator of G-protein signaling 2 1.11046
PRKCE protein kinase C, epsilon 1.10838
WARS tryptophanyl-tRNA synthetase 1.10803
ITGB5 integrin, beta 5 1.10769
TBXA2R thromboxane A2 receptor 1.10769
S100A8 S100 calcium binding protein A8 1.10699
PENK proenkephalin 1.10699
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.10527
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.10527
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.10493
GRM5 glutamate receptor, metabotropic 5 1.10493
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 1.10459
TWF2 twinfilin actin binding protein 2 1.10388
GPX2 glutathione peroxidase 2 1.10353
TRAF3IP2 TRAF3 interacting protein 2 1.10353
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.10317
KCNT1 potassium channel, sodium activated subfamily T, member 1 1.10317
BBC3 BCL2 binding component 3 1.10175
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 1.09998
LCK LCK proto-oncogene, Src family tyrosine kinase 1.09892
CYBB cytochrome b-245, beta polypeptide 1.09857
PSAP prosaposin 1.09857
EBP emopamil binding protein (sterol isomerase) 1.09857
LDB2 LIM domain binding 2 1.09611
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.09541
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.09506
DUSP6 dual specificity phosphatase 6 1.09506
MAP2K2 mitogen-activated protein kinase kinase 2 1.09154
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.09011
CRH corticotropin releasing hormone 1.08868
ARRDC3 arrestin domain containing 3 1.0869
LTB lymphotoxin beta (TNF superfamily, member 3) 1.0869
CCND3 cyclin D3 1.08372
SYT11 synaptotagmin XI 1.08372
EIF5A eukaryotic translation initiation factor 5A 1.08372
SEPT8 septin 8 1.08266
TXNRD1 thioredoxin reductase 1 1.08196
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.08091
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 1.07804
PTBP2 polypyrimidine tract binding protein 2 1.07732
NPY neuropeptide Y 1.07732
TGFB2 transforming growth factor, beta 2 1.07589
IL12B interleukin 12B 1.07589
FN1 fibronectin 1 1.07482
BAK1 BCL2-antagonist/killer 1 1.07447
DRD1 dopamine receptor D1 1.07447
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 1.07269
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.07269
LPIN1 lipin 1 1.07234
CLSTN1 calsyntenin 1 1.07057
NME6 NME/NM23 nucleoside diphosphate kinase 6 1.07057
EPHB3 EPH receptor B3 1.07022
CNR1 cannabinoid receptor 1 (brain) 1.06808
PTX3 pentraxin 3, long 1.06734
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.06698
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.06661
CRYAB crystallin, alpha B 1.06661
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.06515
FPR1 formyl peptide receptor 1 1.06442
CCND2 cyclin D2 1.06225
STAT5A signal transducer and activator of transcription 5A 1.06188
PER1 period circadian clock 1 1.06188
MAPK8 mitogen-activated protein kinase 8 1.06152
ERBB2 erb-b2 receptor tyrosine kinase 2 1.0608
PLAUR plasminogen activator, urokinase receptor 1.0608
SOD2 superoxide dismutase 2, mitochondrial 1.05972
RNF144B ring finger protein 144B 1.05936
SFPQ splicing factor proline/glutamine-rich 1.059
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.05793
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.05757
LCN2 lipocalin 2 1.05757
COL18A1 collagen, type XVIII, alpha 1 1.05685
CDK1 cyclin-dependent kinase 1 1.05573
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.05312
ABLIM3 actin binding LIM protein family, member 3 1.05274
UBC ubiquitin C 1.05163
LITAF lipopolysaccharide-induced TNF factor 1.05126
TF transferrin 1.04904
PLLP plasmolipin 1.04684
PPIH peptidylprolyl isomerase H (cyclophilin H) 1.04684
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 1.04684
RERG RAS-like, estrogen-regulated, growth inhibitor 1.04684
DDIT4 DNA-damage-inducible transcript 4 1.04611
IGF1R insulin-like growth factor 1 receptor 1.04611
SLC19A1 solute carrier family 19 (folate transporter), member 1 1.04389
SOCS5 suppressor of cytokine signaling 5 1.04126
SNRPA small nuclear ribonucleoprotein polypeptide A 1.04126
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 1.04126
SQSTM1 sequestosome 1 1.04051
COL1A2 collagen, type I, alpha 2 1.03789
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.03752
IGSF1 immunoglobulin superfamily, member 1 1.03678
GPRC5C G protein-coupled receptor, class C, group 5, member C 1.03604
SALL1 spalt-like transcription factor 1 1.03604
PHLDB1 pleckstrin homology-like domain, family B, member 1 1.03604
PPAN peter pan homolog (Drosophila) 1.03604
TMOD1 tropomodulin 1 1.03604
GJB2 gap junction protein, beta 2, 26kDa 1.03419
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.03419
PPAP2B phosphatidic acid phosphatase type 2B 1.03159
DUSP5 dual specificity phosphatase 5 1.03159
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 1.03159
GPNMB glycoprotein (transmembrane) nmb 1.03159
FOXN3 forkhead box N3 1.03084
TIMP4 TIMP metallopeptidase inhibitor 4 1.02708
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.02708
NR1D1 nuclear receptor subfamily 1, group D, member 1 1.02708
CKS2 CDC28 protein kinase regulatory subunit 2 1.02671
PRPF4B pre-mRNA processing factor 4B 1.02671
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 1.02559
NCF4 neutrophil cytosolic factor 4, 40kDa 1.02559
NCOA2 nuclear receptor coactivator 2 1.02262
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1.02225
FLRT2 fibronectin leucine rich transmembrane protein 2 1.02188
TRIM28 tripartite motif containing 28 1.02151
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 1.02114
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 1.0204
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.02003
LTF lactotransferrin 1.01814
TBX21 T-box 21 1.01701
AMIGO2 adhesion molecule with Ig-like domain 2 1.01625
CPM carboxypeptidase M 1.01587
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 1.01549
PTGES prostaglandin E synthase 1.01399
SEC31A SEC31 homolog A (S. cerevisiae) 1.01174