Prestwick-984-4948 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the Prestwick-984-4948 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIF1 allograft inflammatory factor 1
ALDOB aldolase B, fructose-bisphosphate
ALOXE3 arachidonate lipoxygenase 3
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATF6B activating transcription factor 6 beta
AUTS2 autism susceptibility candidate 2
BLNK B-cell linker
C15ORF39 chromosome 15 open reading frame 39
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CAMK1 calcium/calmodulin-dependent protein kinase I
CCDC85C coiled-coil domain containing 85C
CD8A CD8a molecule
CDADC1 cytidine and dCMP deaminase domain containing 1
CES3 carboxylesterase 3
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DLG5 discs, large homolog 5 (Drosophila)
DOCK6 dedicator of cytokinesis 6
DRD2 dopamine receptor D2
DSPP dentin sialophosphoprotein
EDNRA endothelin receptor type A
EFCAB11 EF-hand calcium binding domain 11
EGFL7 EGF-like-domain, multiple 7
ELSPBP1 epididymal sperm binding protein 1
FAM46C family with sequence similarity 46, member C
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FHL1 four and a half LIM domains 1
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GLDC glycine dehydrogenase (decarboxylating)
GP5 glycoprotein V (platelet)
HBB hemoglobin, beta
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST1H4D histone cluster 1, H4d
HOMER3 homer scaffolding protein 3
HOXD11 homeobox D11
HR hair growth associated
IDS iduronate 2-sulfatase
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGLJ3 immunoglobulin lambda joining 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LHX2 LIM homeobox 2
LMF2 lipase maturation factor 2
LRRC15 leucine rich repeat containing 15
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LY6G6C lymphocyte antigen 6 complex, locus G6C
MEF2D myocyte enhancer factor 2D
METTL7A methyltransferase like 7A
MFAP3L microfibrillar-associated protein 3-like
MMP3 matrix metallopeptidase 3
MRPS18C mitochondrial ribosomal protein S18C
MTRF1L mitochondrial translational release factor 1-like
NOP16 NOP16 nucleolar protein
NPR3 natriuretic peptide receptor 3
NR2E3 nuclear receptor subfamily 2, group E, member 3
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OLFML2A olfactomedin-like 2A
OR2H2 olfactory receptor, family 2, subfamily H, member 2
OR7A5 olfactory receptor, family 7, subfamily A, member 5
PAX5 paired box 5
PDGFA platelet-derived growth factor alpha polypeptide
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLCG1 phospholipase C, gamma 1
PLD1 phospholipase D1, phosphatidylcholine-specific
POPDC3 popeye domain containing 3
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R17 protein phosphatase 1, regulatory subunit 17
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RB1 retinoblastoma 1
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RBM5 RNA binding motif protein 5
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
SETBP1 SET binding protein 1
SIDT2 SID1 transmembrane family, member 2
SIRT5 sirtuin 5
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMC4 structural maintenance of chromosomes 4
SRCAP Snf2-related CREBBP activator protein
SSX3 synovial sarcoma, X breakpoint 3
SUGP1 SURP and G patch domain containing 1
TREM1 triggering receptor expressed on myeloid cells 1
TREX1 three prime repair exonuclease 1
TRGV5 T cell receptor gamma variable 5
TRIM36 tripartite motif containing 36
TUBA4B tubulin, alpha 4b
USP19 ubiquitin specific peptidase 19
USP22 ubiquitin specific peptidase 22
VWA5A von Willebrand factor A domain containing 5A
WSCD1 WSC domain containing 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XYLB xylulokinase homolog (H. influenzae)
ZC3H13 zinc finger CCCH-type containing 13
ZNF446 zinc finger protein 446
ZNF682 zinc finger protein 682

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
ACTG2 actin, gamma 2, smooth muscle, enteric
ANXA2P3 annexin A2 pseudogene 3
ATP13A2 ATPase type 13A2
BAHCC1 BAH domain and coiled-coil containing 1
C19ORF40 chromosome 19 open reading frame 40
C1ORF105 chromosome 1 open reading frame 105
CCDC186 coiled-coil domain containing 186
CFD complement factor D (adipsin)
CLDN1 claudin 1
CNGB3 cyclic nucleotide gated channel beta 3
COMMD9 COMM domain containing 9
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOC2A double C2-like domains, alpha
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ECHDC3 enoyl CoA hydratase domain containing 3
EFHD2 EF-hand domain family, member D2
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCHO1 FCH domain only 1
GAB2 GRB2-associated binding protein 2
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
HIST1H2AM histone cluster 1, H2am
HOXA4 homeobox A4
HYAL2 hyaluronoglucosaminidase 2
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGSF1 immunoglobulin superfamily, member 1
IL22 interleukin 22
IRF2BP1 interferon regulatory factor 2 binding protein 1
JUNB jun B proto-oncogene
KIAA0754 KIAA0754
LHX6 LIM homeobox 6
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MB myoglobin
MED24 mediator complex subunit 24
MED9 mediator complex subunit 9
METTL16 methyltransferase like 16
MICALL2 MICAL-like 2
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MOSPD3 motile sperm domain containing 3
MRPL44 mitochondrial ribosomal protein L44
N4BP3 NEDD4 binding protein 3
NSD1 nuclear receptor binding SET domain protein 1
NT5C 5', 3'-nucleotidase, cytosolic
NT5E 5'-nucleotidase, ecto (CD73)
ONECUT2 one cut homeobox 2
PADI1 peptidyl arginine deiminase, type I
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PGBD5 piggyBac transposable element derived 5
PHEX phosphate regulating endopeptidase homolog, X-linked
PLCD1 phospholipase C, delta 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLEKHO1 pleckstrin homology domain containing, family O member 1
POLL polymerase (DNA directed), lambda
PPP1R9A protein phosphatase 1, regulatory subunit 9A
RASAL1 RAS protein activator like 1 (GAP1 like)
RLN1 relaxin 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SETD8 SET domain containing (lysine methyltransferase) 8
SH2B3 SH2B adaptor protein 3
SH2D4A SH2 domain containing 4A
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLMO1 slowmo homolog 1 (Drosophila)
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SREBF2 sterol regulatory element binding transcription factor 2
STK16 serine/threonine kinase 16
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBC1D17 TBC1 domain family, member 17
TRIM21 tripartite motif containing 21
TRIM25 tripartite motif containing 25
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN5 tetraspanin 5
TTC23 tetratricopeptide repeat domain 23
TUBA3C tubulin, alpha 3c
UCN urocortin
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR25 WD repeat domain 25
WDR4 WD repeat domain 4
WFDC2 WAP four-disulfide core domain 2
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZBED1 zinc finger, BED-type containing 1
ZBTB22 zinc finger and BTB domain containing 22
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF16 zinc finger protein 16
ZNF304 zinc finger protein 304
ZNF37BP zinc finger protein 37B, pseudogene
ZNF552 zinc finger protein 552
ZNF557 zinc finger protein 557
ZNF639 zinc finger protein 639
ZNF750 zinc finger protein 750