Prestwick-983-7480 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the Prestwick-983-7480 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ALAS1 5'-aminolevulinate synthase 1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BAHCC1 BAH domain and coiled-coil containing 1
C5ORF45 chromosome 5 open reading frame 45
CCDC25 coiled-coil domain containing 25
CDK13 cyclin-dependent kinase 13
CEP97 centrosomal protein 97kDa
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLMN calmin (calponin-like, transmembrane)
CREM cAMP responsive element modulator
CRTC1 CREB regulated transcription coactivator 1
CST6 cystatin E/M
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
E2F1 E2F transcription factor 1
EGFL7 EGF-like-domain, multiple 7
ETNK2 ethanolamine kinase 2
EVA1B eva-1 homolog B (C. elegans)
FGD1 FYVE, RhoGEF and PH domain containing 1
FGF6 fibroblast growth factor 6
FGFR2 fibroblast growth factor receptor 2
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GID4 GID complex subunit 4
GRTP1 growth hormone regulated TBC protein 1
HIST1H1B histone cluster 1, H1b
HYI hydroxypyruvate isomerase (putative)
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL11 interleukin 11
IL22RA1 interleukin 22 receptor, alpha 1
IPW imprinted in Prader-Willi syndrome (non-protein coding)
IRS2 insulin receptor substrate 2
ITPK1 inositol-tetrakisphosphate 1-kinase
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KDM5D lysine (K)-specific demethylase 5D
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
LOC399491
LPPR2 lipid phosphate phosphatase-related protein type 2
LRRC37A3 leucine rich repeat containing 37, member A3
MAGEA3 melanoma antigen family A3
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MAP4 microtubule-associated protein 4
MDM4 MDM4, p53 regulator
MMP3 matrix metallopeptidase 3
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYOF myoferlin
NAAA N-acylethanolamine acid amidase
NDRG4 NDRG family member 4
NELL2 NEL-like 2 (chicken)
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PCDHGA3 protocadherin gamma subfamily A, 3
PDCD6 programmed cell death 6
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHO2 pleckstrin homology domain containing, family O member 2
PML promyelocytic leukemia
POFUT1 protein O-fucosyltransferase 1
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRPH peripherin
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTAFR platelet-activating factor receptor
RAB30 RAB30, member RAS oncogene family
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RECQL5 RecQ protein-like 5
RHBDD3 rhomboid domain containing 3
RNF39 ring finger protein 39
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RREB1 ras responsive element binding protein 1
S100A8 S100 calcium binding protein A8
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SH2D1A SH2 domain containing 1A
SNHG3 small nucleolar RNA host gene 3
STAT5B signal transducer and activator of transcription 5B
STS steroid sulfatase (microsomal), isozyme S
STX7 syntaxin 7
SUGP1 SURP and G patch domain containing 1
SZT2 seizure threshold 2 homolog (mouse)
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TBC1D5 TBC1 domain family, member 5
TBX19 T-box 19
THBS3 thrombospondin 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TLE4 transducin-like enhancer of split 4
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TP63 tumor protein p63
TRAK1 trafficking protein, kinesin binding 1
TTLL3 tubulin tyrosine ligase-like family member 3
UBE3B ubiquitin protein ligase E3B
USP19 ubiquitin specific peptidase 19
WDTC1 WD and tetratricopeptide repeats 1
ZBED1 zinc finger, BED-type containing 1
ZNF484 zinc finger protein 484

decreased expression

Symbol Name
AFF4 AF4/FMR2 family, member 4
ALG12 ALG12, alpha-1,6-mannosyltransferase
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAG4 BCL2-associated athanogene 4
BAGE B melanoma antigen
BCAS1 breast carcinoma amplified sequence 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCORL1 BCL6 corepressor-like 1
BICD1 bicaudal D homolog 1 (Drosophila)
BPGM 2,3-bisphosphoglycerate mutase
C11ORF80 chromosome 11 open reading frame 80
C17ORF80 chromosome 17 open reading frame 80
C2ORF27A chromosome 2 open reading frame 27A
C4ORF29 chromosome 4 open reading frame 29
C5 complement component 5
C7ORF43 chromosome 7 open reading frame 43
CAPRIN2 caprin family member 2
CBX8 chromobox homolog 8
CCDC85C coiled-coil domain containing 85C
CCDC9 coiled-coil domain containing 9
CDK5 cyclin-dependent kinase 5
CHKB choline kinase beta
CRYBG3 beta-gamma crystallin domain containing 3
CTNNBIP1 catenin, beta interacting protein 1
DCAF13 DDB1 and CUL4 associated factor 13
DDIT3 DNA-damage-inducible transcript 3
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSE dermatan sulfate epimerase
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFNA3 ephrin-A3
FAM63A family with sequence similarity 63, member A
FILIP1L filamin A interacting protein 1-like
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
FSD1 fibronectin type III and SPRY domain containing 1
GLB1L2 galactosidase, beta 1-like 2
GMIP GEM interacting protein
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPR27 G protein-coupled receptor 27
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST2H2AA3 histone cluster 2, H2aa3
HLA-J major histocompatibility complex, class I, J (pseudogene)
HMOX1 heme oxygenase 1
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IFT140 intraflagellar transport 140
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITPKC inositol-trisphosphate 3-kinase C
KLF3 Kruppel-like factor 3 (basic)
KREMEN2 kringle containing transmembrane protein 2
LGALS4 lectin, galactoside-binding, soluble, 4
LPXN leupaxin
LTBP2 latent transforming growth factor beta binding protein 2
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK12 mitogen-activated protein kinase 12
MEIS2 Meis homeobox 2
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL52 mitochondrial ribosomal protein L52
NDE1 nudE neurodevelopment protein 1
NT5DC3 5'-nucleotidase domain containing 3
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
ODF2 outer dense fiber of sperm tails 2
OSMR oncostatin M receptor
PACS1 phosphofurin acidic cluster sorting protein 1
PARP12 poly (ADP-ribose) polymerase family, member 12
PGR progesterone receptor
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLA2G15 phospholipase A2, group XV
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RECQL4 RecQ protein-like 4
RFTN1 raftlin, lipid raft linker 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SHPK sedoheptulokinase
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SND1-IT1 SND1 intronic transcript 1
THRAP3 thyroid hormone receptor associated protein 3
TMPRSS4 transmembrane protease, serine 4
TMSB15A thymosin beta 15a
TPST1 tyrosylprotein sulfotransferase 1
TRAF5 TNF receptor-associated factor 5
TRAPPC11 trafficking protein particle complex 11
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSSC4 tumor suppressing subtransferable candidate 4
TWSG1 twisted gastrulation BMP signaling modulator 1
UNC119 unc-119 homolog (C. elegans)
USB1 U6 snRNA biogenesis 1
USP18 ubiquitin specific peptidase 18
VASP vasodilator-stimulated phosphoprotein
VEGFC vascular endothelial growth factor C
ZNF778 zinc finger protein 778
ZSCAN26 zinc finger and SCAN domain containing 26
ZSCAN9 zinc finger and SCAN domain containing 9