Prestwick-983-3141 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the Prestwick-983-3141 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD6 abhydrolase domain containing 6
ADARB1 adenosine deaminase, RNA-specific, B1
AREG amphiregulin
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARL4C ADP-ribosylation factor-like 4C
AXL AXL receptor tyrosine kinase
BIN1 bridging integrator 1
BMP6 bone morphogenetic protein 6
C11ORF16 chromosome 11 open reading frame 16
CCL22 chemokine (C-C motif) ligand 22
CD38 CD38 molecule
CD86 CD86 molecule
CHN2 chimerin 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLCF1 cardiotrophin-like cytokine factor 1
COL4A2 collagen, type IV, alpha 2
CREM cAMP responsive element modulator
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
DNAH17 dynein, axonemal, heavy chain 17
DOCK4 dedicator of cytokinesis 4
DPYSL3 dihydropyrimidinase-like 3
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FADS3 fatty acid desaturase 3
FOXA1 forkhead box A1
FOXO1 forkhead box O1
FTH1 ferritin, heavy polypeptide 1
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GEM GTP binding protein overexpressed in skeletal muscle
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNLY granulysin
GPR183 G protein-coupled receptor 183
GRAMD1B GRAM domain containing 1B
HIST1H2AJ histone cluster 1, H2aj
HLA-DRA major histocompatibility complex, class II, DR alpha
HP haptoglobin
HPSE heparanase
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI30 interferon, gamma-inducible protein 30
IL11 interleukin 11
IL1R1 interleukin 1 receptor, type I
IL7R interleukin 7 receptor
ISG20 interferon stimulated exonuclease gene 20kDa
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KYNU kynureninase
LAMB3 laminin, beta 3
LXN latexin
MCAM melanoma cell adhesion molecule
MCTP2 multiple C2 domains, transmembrane 2
MOB3B MOB kinase activator 3B
MTUS1 microtubule associated tumor suppressor 1
MX2 MX dynamin-like GTPase 2
MXRA8 matrix-remodelling associated 8
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PINK1 PTEN induced putative kinase 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRL prolactin
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
QDPR quinoid dihydropteridine reductase
RAP1GAP2 RAP1 GTPase activating protein 2
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB1 SATB homeobox 1
SDC2 syndecan 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH2D2A SH2 domain containing 2A
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SMOX spermine oxidase
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
STAT4 signal transducer and activator of transcription 4
SYCP2 synaptonemal complex protein 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TKTL1 transketolase-like 1
TRPS1 trichorhinophalangeal syndrome I
TUBB2A tubulin, beta 2A class IIa
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADRB2 adrenoceptor beta 2, surface
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ANKRD55 ankyrin repeat domain 55
ANXA3 annexin A3
ARRB1 arrestin, beta 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BYSL bystin-like
C10ORF2 chromosome 10 open reading frame 2
C17ORF70 chromosome 17 open reading frame 70
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CCNA1 cyclin A1
CD69 CD69 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DCAF13 DDB1 and CUL4 associated factor 13
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DKC1 dyskeratosis congenita 1, dyskerin
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EBNA1BP2 EBNA1 binding protein 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ERCC2 excision repair cross-complementation group 2
EXOSC5 exosome component 5
FAM216A family with sequence similarity 216, member A
FAR2 fatty acyl CoA reductase 2
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FKBP5 FK506 binding protein 5
FLT3 fms-related tyrosine kinase 3
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HOPX HOP homeobox
IFITM3 interferon induced transmembrane protein 3
IFRD2 interferon-related developmental regulator 2
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INHBE inhibin, beta E
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KIAA0020 KIAA0020
LTB lymphotoxin beta (TNF superfamily, member 3)
MAK16 MAK16 homolog (S. cerevisiae)
METTL1 methyltransferase like 1
MPI mannose phosphate isomerase
MRPL12 mitochondrial ribosomal protein L12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NAT10 N-acetyltransferase 10 (GCN5-related)
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NIP7 NIP7, nucleolar pre-rRNA processing protein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PES1 pescadillo ribosomal biogenesis factor 1
PFAS phosphoribosylformylglycinamidine synthase
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PPAN peter pan homolog (Drosophila)
PRDM13 PR domain containing 13
PRTN3 proteinase 3
PSAT1 phosphoserine aminotransferase 1
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTRH2 peptidyl-tRNA hydrolase 2
PUS1 pseudouridylate synthase 1
PUS7 pseudouridylate synthase 7 (putative)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RHOBTB2 Rho-related BTB domain containing 2
RPIA ribose 5-phosphate isomerase A
RPP40 ribonuclease P/MRP 40kDa subunit
RRP1 ribosomal RNA processing 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRM spermidine synthase
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TEC tec protein tyrosine kinase
TERT telomerase reverse transcriptase
TMEM104 transmembrane protein 104
TRPV2 transient receptor potential cation channel, subfamily V, member 2
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
WDR12 WD repeat domain 12
WDR46 WD repeat domain 46
WT1 Wilms tumor 1
XYLT2 xylosyltransferase II
YARS tyrosyl-tRNA synthetase
ZNF692 zinc finger protein 692