Prestwick-981-6504 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the Prestwick-981-6504 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACTN2 actinin, alpha 2
ADGRE2 adhesion G protein-coupled receptor E2
AFF2 AF4/FMR2 family, member 2
AGO4 argonaute RISC catalytic component 4
AKR1C2 aldo-keto reductase family 1, member C2
ANKFY1 ankyrin repeat and FYVE domain containing 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APOM apolipoprotein M
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARTN artemin
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCL2 B-cell CLL/lymphoma 2
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC25A cell division cycle 25A
CDRT1 CMT1A duplicated region transcript 1
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CLPS colipase, pancreatic
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COL4A1 collagen, type IV, alpha 1
CRHR2 corticotropin releasing hormone receptor 2
CSPP1 centrosome and spindle pole associated protein 1
CUL4B cullin 4B
CUZD1 CUB and zona pellucida-like domains 1
DCAF11 DDB1 and CUL4 associated factor 11
DGAT1 diacylglycerol O-acyltransferase 1
EFNA3 ephrin-A3
EFNB3 ephrin-B3
ELAC2 elaC ribonuclease Z 2
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FAS Fas cell surface death receptor
FPR1 formyl peptide receptor 1
GALC galactosylceramidase
GMPR guanosine monophosphate reductase
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GREB1 growth regulation by estrogen in breast cancer 1
GSTCD glutathione S-transferase, C-terminal domain containing
GZMK granzyme K (granzyme 3; tryptase II)
HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene)
HPGDS hematopoietic prostaglandin D synthase
IPO8 importin 8
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRIT1 KRIT1, ankyrin repeat containing
LMF2 lipase maturation factor 2
MAP2K2 mitogen-activated protein kinase kinase 2
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MBD3 methyl-CpG binding domain protein 3
MKL1 megakaryoblastic leukemia (translocation) 1
MPL MPL proto-oncogene, thrombopoietin receptor
MST1R macrophage stimulating 1 receptor
MTA1 metastasis associated 1
MTRF1L mitochondrial translational release factor 1-like
NPR3 natriuretic peptide receptor 3
NUDCD3 NudC domain containing 3
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PARD6B par-6 family cell polarity regulator beta
PAX2 paired box 2
PBX2 pre-B-cell leukemia homeobox 2
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PML promyelocytic leukemia
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R37 protein phosphatase 1, regulatory subunit 37
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRR4 proline rich 4 (lacrimal)
PTRF polymerase I and transcript release factor
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RARG retinoic acid receptor, gamma
REM1 RAS (RAD and GEM)-like GTP-binding 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
SAFB scaffold attachment factor B
SBF1 SET binding factor 1
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYNDIG1 synapse differentiation inducing 1
SYNE1 spectrin repeat containing, nuclear envelope 1
TAOK1 TAO kinase 1
TBC1D19 TBC1 domain family, member 19
TBRG4 transforming growth factor beta regulator 4
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TLN1 talin 1
TMPRSS2 transmembrane protease, serine 2
TPMT thiopurine S-methyltransferase
TRBC1 T cell receptor beta constant 1
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae)
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WIPI2 WD repeat domain, phosphoinositide interacting 2
ZFP36L1 ZFP36 ring finger protein-like 1
ZFPL1 zinc finger protein-like 1
ZNF134 zinc finger protein 134
ZNF224 zinc finger protein 224
ZNF34 zinc finger protein 34
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ACYP2 acylphosphatase 2, muscle type
AFAP1 actin filament associated protein 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ARHGAP11A Rho GTPase activating protein 11A
ARHGAP24 Rho GTPase activating protein 24
ARHGAP4 Rho GTPase activating protein 4
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BCAS1 breast carcinoma amplified sequence 1
C1ORF105 chromosome 1 open reading frame 105
C5AR2 complement component 5a receptor 2
C8ORF60 chromosome 8 open reading frame 60
C9ORF40 chromosome 9 open reading frame 40
CCDC25 coiled-coil domain containing 25
CCNO cyclin O
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CEL carboxyl ester lipase
CENPQ centromere protein Q
CGREF1 cell growth regulator with EF-hand domain 1
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNN2 calponin 2
CUL9 cullin 9
DACH1 dachshund family transcription factor 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNM1 dynamin 1
DSPP dentin sialophosphoprotein
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EMID1 EMI domain containing 1
GADD45G growth arrest and DNA-damage-inducible, gamma
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GPR3 G protein-coupled receptor 3
GTF2A1 general transcription factor IIA, 1, 19/37kDa
H1F0 H1 histone family, member 0
HCFC1 host cell factor C1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IL4R interleukin 4 receptor
IRX4 iroquois homeobox 4
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM8 lysine (K)-specific demethylase 8
KIF13B kinesin family member 13B
KLHL12 kelch-like family member 12
KLHL25 kelch-like family member 25
LAMA3 laminin, alpha 3
LENEP lens epithelial protein
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC390998 ribosomal protein L10 pseudogene
LOC729164 hCG1732469
LOXL3 lysyl oxidase-like 3
LYRM9 LYR motif containing 9
MAP1S microtubule-associated protein 1S
MED9 mediator complex subunit 9
MPI mannose phosphate isomerase
MTSS1L metastasis suppressor 1-like
MUC3A mucin 3A, cell surface associated
NRGN neurogranin (protein kinase C substrate, RC3)
PADI1 peptidyl arginine deiminase, type I
PAIP2B poly(A) binding protein interacting protein 2B
PARP16 poly (ADP-ribose) polymerase family, member 16
PCDHB3 protocadherin beta 3
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PLD2 phospholipase D2
PRF1 perforin 1 (pore forming protein)
PRKX protein kinase, X-linked
PRSS53 protease, serine, 53
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RANGRF RAN guanine nucleotide release factor
RARS arginyl-tRNA synthetase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RHBG Rh family, B glycoprotein (gene/pseudogene)
SAYSD1 SAYSVFN motif domain containing 1
SCAMP3 secretory carrier membrane protein 3
SCN10A sodium channel, voltage gated, type X alpha subunit
SDC3 syndecan 3
SECTM1 secreted and transmembrane 1
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SH2D4A SH2 domain containing 4A
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPINK5 serine peptidase inhibitor, Kazal type 5
STEAP4 STEAP family member 4
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCTN1 tectonic family member 1
TET3 tet methylcytosine dioxygenase 3
TICAM1 toll-like receptor adaptor molecule 1
TIGD6 tigger transposable element derived 6
TMEM53 transmembrane protein 53
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TTLL1 tubulin tyrosine ligase-like family member 1
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
ZNF16 zinc finger protein 16
ZNF573 zinc finger protein 573
ZNF586 zinc finger protein 586
ZNF611 zinc finger protein 611