Prestwick-981-3125 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the Prestwick-981-3125 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABI2 abl-interactor 2
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ALB albumin
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
AMPH amphiphysin
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
APOD apolipoprotein D
AREG amphiregulin
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
C11ORF16 chromosome 11 open reading frame 16
CAT catalase
CCDC71 coiled-coil domain containing 71
CD59 CD59 molecule, complement regulatory protein
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CEP41 centrosomal protein 41kDa
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CLIP1 CAP-GLY domain containing linker protein 1
COL9A3 collagen, type IX, alpha 3
CRY2 cryptochrome circadian clock 2
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CYLD cylindromatosis (turban tumor syndrome)
DMC1 DNA meiotic recombinase 1
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DOCK6 dedicator of cytokinesis 6
DVL2 dishevelled segment polarity protein 2
ECE1 endothelin converting enzyme 1
EFNA5 ephrin-A5
EHD1 EH-domain containing 1
ENDOD1 endonuclease domain containing 1
FAM127B family with sequence similarity 127, member B
FBXO31 F-box protein 31
FGD1 FYVE, RhoGEF and PH domain containing 1
FN1 fibronectin 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAS6 growth arrest-specific 6
GLP1R glucagon-like peptide 1 receptor
HABP4 hyaluronan binding protein 4
HOXD1 homeobox D1
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCTD13 potassium channel tetramerization domain containing 13
KIF17 kinesin family member 17
KLF3 Kruppel-like factor 3 (basic)
LOC730101 uncharacterized LOC730101
LRRN2 leucine rich repeat neuronal 2
MAN1A2 mannosidase, alpha, class 1A, member 2
MAPK11 mitogen-activated protein kinase 11
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MLXIPL MLX interacting protein-like
MPDZ multiple PDZ domain protein
MST1L macrophage stimulating 1-like
NBL1 neuroblastoma 1, DAN family BMP antagonist
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NR4A3 nuclear receptor subfamily 4, group A, member 3
OMG oligodendrocyte myelin glycoprotein
PAX3 paired box 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFB platelet-derived growth factor beta polypeptide
PER3 period circadian clock 3
PFN2 profilin 2
PLSCR4 phospholipid scramblase 4
POMZP3 POM121 and ZP3 fusion
PORCN porcupine homolog (Drosophila)
PPARD peroxisome proliferator-activated receptor delta
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKCE protein kinase C, epsilon
PRPF18 pre-mRNA processing factor 18
RAP1GAP RAP1 GTPase activating protein
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RRBP1 ribosome binding protein 1
RTEL1 regulator of telomere elongation helicase 1
S100A2 S100 calcium binding protein A2
SBNO2 strawberry notch homolog 2 (Drosophila)
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SGK2 serum/glucocorticoid regulated kinase 2
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SPRR1B small proline-rich protein 1B
SRPK3 SRSF protein kinase 3
SRR serine racemase
SUGP1 SURP and G patch domain containing 1
TEX40 testis expressed 40
THBS1 thrombospondin 1
TMC7 transmembrane channel-like 7
TMCC2 transmembrane and coiled-coil domain family 2
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
UBOX5 U-box domain containing 5
WASF3 WAS protein family, member 3
YPEL1 yippee-like 1 (Drosophila)
ZC3H7B zinc finger CCCH-type containing 7B
ZER1 zyg-11 related, cell cycle regulator
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF407 zinc finger protein 407
ZNF473 zinc finger protein 473

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
BEND5 BEN domain containing 5
BEST1 bestrophin 1
CD34 CD34 molecule
CENPO centromere protein O
CIDEC cell death-inducing DFFA-like effector c
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CORO7 coronin 7
CORT cortistatin
CPTP ceramide-1-phosphate transfer protein
CROT carnitine O-octanoyltransferase
CXCL2 chemokine (C-X-C motif) ligand 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
E4F1 E4F transcription factor 1
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
FAM135A family with sequence similarity 135, member A
FAM173A family with sequence similarity 173, member A
FGF22 fibroblast growth factor 22
FKBP5 FK506 binding protein 5
FRS2 fibroblast growth factor receptor substrate 2
GLRA1 glycine receptor, alpha 1
GPATCH3 G patch domain containing 3
HIST1H2BJ histone cluster 1, H2bj
HIST1H4D histone cluster 1, H4d
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXA5 homeobox A5
HYAL3 hyaluronoglucosaminidase 3
IDI2-AS1 IDI2 antisense RNA 1
IFITM3 interferon induced transmembrane protein 3
IL12B interleukin 12B
JMJD4 jumonji domain containing 4
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0319L KIAA0319-like
KRI1 KRI1 homolog (S. cerevisiae)
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LIN7B lin-7 homolog B (C. elegans)
LRRK1 leucine-rich repeat kinase 1
LSP1 lymphocyte-specific protein 1
MAGEF1 melanoma antigen family F1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
METTL8 methyltransferase like 8
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYBPH myosin binding protein H
NABP2 nucleic acid binding protein 2
NAG18 NAG18 mRNA
NFE2L3 nuclear factor, erythroid 2-like 3
NT5DC3 5'-nucleotidase domain containing 3
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PARP11 poly (ADP-ribose) polymerase family, member 11
PCDHGA10 protocadherin gamma subfamily A, 10
PDE8B phosphodiesterase 8B
PIP prolactin-induced protein
PLCD1 phospholipase C, delta 1
POTEKP POTE ankyrin domain family, member K, pseudogene
PTDSS2 phosphatidylserine synthase 2
RIN1 Ras and Rab interactor 1
RND1 Rho family GTPase 1
RNF122 ring finger protein 122
RNF126P1 ring finger protein 126 pseudogene 1
RPAP2 RNA polymerase II associated protein 2
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAS related RAS viral (r-ras) oncogene homolog
SARS2 seryl-tRNA synthetase 2, mitochondrial
SETD1A SET domain containing 1A
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SIK1 salt-inducible kinase 1
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC35F6 solute carrier family 35, member F6
SNAP29 synaptosomal-associated protein, 29kDa
SPHK1 sphingosine kinase 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TIGD6 tigger transposable element derived 6
TMEM184C transmembrane protein 184C
TMEM187 transmembrane protein 187
TMEM206 transmembrane protein 206
TMEM212 transmembrane protein 212
TPM3 tropomyosin 3
TRAF2 TNF receptor-associated factor 2
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
UBTD1 ubiquitin domain containing 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WNT16 wingless-type MMTV integration site family, member 16
YOD1 YOD1 deubiquitinase
ZFHX3 zinc finger homeobox 3
ZNF234 zinc finger protein 234
ZNF528 zinc finger protein 528
ZNF668 zinc finger protein 668
ZNF701 zinc finger protein 701