Prestwick-972-7266 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the Prestwick-972-7266 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY6 adenylate cyclase 6
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ANOS1 anosmin 1
ANP32A-IT1 ANP32A intronic transcript 1
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
ATAT1 alpha tubulin acetyltransferase 1
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
B3GAT3 beta-1,3-glucuronyltransferase 3
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BMP1 bone morphogenetic protein 1
BMP4 bone morphogenetic protein 4
BRD4 bromodomain containing 4
CABIN1 calcineurin binding protein 1
CCP110 centriolar coiled coil protein 110kDa
CD58 CD58 molecule
CEP104 centrosomal protein 104kDa
CFAP44 cilia and flagella associated protein 44
COL3A1 collagen, type III, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CST1 cystatin SN
CTC1 CTS telomere maintenance complex component 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
EML3 echinoderm microtubule associated protein like 3
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPHX2 epoxide hydrolase 2, cytoplasmic
EVPL envoplakin
FANCA Fanconi anemia, complementation group A
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FOXN3 forkhead box N3
GBP1 guanylate binding protein 1, interferon-inducible
GPC3 glypican 3
HAUS6 HAUS augmin-like complex, subunit 6
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HOXB9 homeobox B9
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL1A interleukin 1, alpha
IL7R interleukin 7 receptor
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIAA1107 KIAA1107
KIF5C kinesin family member 5C
LDB1 LIM domain binding 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRRC41 leucine rich repeat containing 41
LRRC61 leucine rich repeat containing 61
MERTK MER proto-oncogene, tyrosine kinase
NF2 neurofibromin 2 (merlin)
NFYA nuclear transcription factor Y, alpha
PBX2 pre-B-cell leukemia homeobox 2
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAB3A RAB3A, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RARG retinoic acid receptor, gamma
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RGS17 regulator of G-protein signaling 17
RGS4 regulator of G-protein signaling 4
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
ROR1 receptor tyrosine kinase-like orphan receptor 1
SENP6 SUMO1/sentrin specific peptidase 6
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC6A16 solute carrier family 6, member 16
SMR3A submaxillary gland androgen regulated protein 3A
SOX4 SRY (sex determining region Y)-box 4
SRCAP Snf2-related CREBBP activator protein
SRD5A3 steroid 5 alpha-reductase 3
SSBP3 single stranded DNA binding protein 3
SSX1 synovial sarcoma, X breakpoint 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STOML1 stomatin (EPB72)-like 1
SYT1 synaptotagmin I
TBX19 T-box 19
THOC5 THO complex 5
TINAGL1 tubulointerstitial nephritis antigen-like 1
TK2 thymidine kinase 2, mitochondrial
TMCO6 transmembrane and coiled-coil domains 6
TMEM8B transmembrane protein 8B
TNC tenascin C
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TUBA3C tubulin, alpha 3c
UNC45A unc-45 homolog A (C. elegans)
VAC14 Vac14 homolog (S. cerevisiae)
WWTR1 WW domain containing transcription regulator 1
ZBTB20 zinc finger and BTB domain containing 20
ZC3H7B zinc finger CCCH-type containing 7B
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADPGK ADP-dependent glucokinase
AIM1 absent in melanoma 1
ANAPC2 anaphase promoting complex subunit 2
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ASB7 ankyrin repeat and SOCS box containing 7
ASS1 argininosuccinate synthase 1
ATAD3A ATPase family, AAA domain containing 3A
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
AUH AU RNA binding protein/enoyl-CoA hydratase
AXIN1 axin 1
C7ORF43 chromosome 7 open reading frame 43
CAPN15 calpain 15
CCNA1 cyclin A1
CDH3 cadherin 3, type 1, P-cadherin (placental)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN15 claudin 15
CSRNP3 cysteine-serine-rich nuclear protein 3
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DTWD1 DTW domain containing 1
EAF2 ELL associated factor 2
EFCAB2 EF-hand calcium binding domain 2
EFNA1 ephrin-A1
EHD3 EH-domain containing 3
EMC9 ER membrane protein complex subunit 9
F8 coagulation factor VIII, procoagulant component
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
HDAC9 histone deacetylase 9
HIST1H1E histone cluster 1, H1e
HIST1H2AI histone cluster 1, H2ai
HLX H2.0-like homeobox
HMHA1 histocompatibility (minor) HA-1
HOXC8 homeobox C8
HTT huntingtin
IFT22 intraflagellar transport 22
IMPAD1 inositol monophosphatase domain containing 1
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JUNB jun B proto-oncogene
KCTD20 potassium channel tetramerization domain containing 20
KIAA0753 KIAA0753
KLK5 kallikrein-related peptidase 5
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MBD5 methyl-CpG binding domain protein 5
MFGE8 milk fat globule-EGF factor 8 protein
MFSD12 major facilitator superfamily domain containing 12
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MPI mannose phosphate isomerase
MSL2 male-specific lethal 2 homolog (Drosophila)
MTRF1 mitochondrial translational release factor 1
MYLK myosin light chain kinase
NAP1L3 nucleosome assembly protein 1-like 3
NBEA neurobeachin
NOL6 nucleolar protein 6 (RNA-associated)
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
OSBP2 oxysterol binding protein 2
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
POU2F1 POU class 2 homeobox 1
PTDSS2 phosphatidylserine synthase 2
PVRL3 poliovirus receptor-related 3
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RGS20 regulator of G-protein signaling 20
RPL23AP32 ribosomal protein L23a pseudogene 32
SCYL2 SCY1-like 2 (S. cerevisiae)
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SH2D4A SH2 domain containing 4A
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC25A40 solute carrier family 25, member 40
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SMA4 glucuronidase, beta pseudogene
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TESPA1 thymocyte expressed, positive selection associated 1
TMC5 transmembrane channel-like 5
TMEM2 transmembrane protein 2
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TTC26 tetratricopeptide repeat domain 26
UBTD1 ubiquitin domain containing 1
URGCP upregulator of cell proliferation
WDR46 WD repeat domain 46
XPC xeroderma pigmentosum, complementation group C
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZBTB48 zinc finger and BTB domain containing 48
ZDHHC14 zinc finger, DHHC-type containing 14
ZFHX3 zinc finger homeobox 3
ZFP69B ZFP69 zinc finger protein B
ZNF33B zinc finger protein 33B
ZNF552 zinc finger protein 552
ZSCAN16 zinc finger and SCAN domain containing 16