Prestwick-972-6511 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the Prestwick-972-6511 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ADAM15 ADAM metallopeptidase domain 15
AFAP1 actin filament associated protein 1
AHNAK2 AHNAK nucleoprotein 2
AK1 adenylate kinase 1
AKAP5 A kinase (PRKA) anchor protein 5
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALPPL2 alkaline phosphatase, placental-like 2
ALS2CL ALS2 C-terminal like
AMPH amphiphysin
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APOA1 apolipoprotein A-I
APOM apolipoprotein M
AQP3 aquaporin 3 (Gill blood group)
ARHGAP35 Rho GTPase activating protein 35
ASPH aspartate beta-hydroxylase
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
C19ORF73 chromosome 19 open reading frame 73
C2 complement component 2
CD34 CD34 molecule
CD8B CD8b molecule
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDRT1 CMT1A duplicated region transcript 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CES3 carboxylesterase 3
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHRND cholinergic receptor, nicotinic, delta (muscle)
CLIC2 chloride intracellular channel 2
CRABP1 cellular retinoic acid binding protein 1
CRIP1 cysteine-rich protein 1 (intestinal)
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DEFA4 defensin, alpha 4, corticostatin
DESI2 desumoylating isopeptidase 2
DGAT1 diacylglycerol O-acyltransferase 1
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
EFNA3 ephrin-A3
ERN2 endoplasmic reticulum to nucleus signaling 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GLUL glutamate-ammonia ligase
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPER1 G protein-coupled estrogen receptor 1
GTPBP1 GTP binding protein 1
HIST1H3E histone cluster 1, H3e
ICA1 islet cell autoantigen 1, 69kDa
IFNA6 interferon, alpha 6
IRS4 insulin receptor substrate 4
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIF5A kinesin family member 5A
KRT83 keratin 83, type II
LMF2 lipase maturation factor 2
MAP2K2 mitogen-activated protein kinase kinase 2
MST1 macrophage stimulating 1
MTRF1L mitochondrial translational release factor 1-like
MYCNOS MYCN opposite strand
MYO7A myosin VIIA
NFX1 nuclear transcription factor, X-box binding 1
NRIP3 nuclear receptor interacting protein 3
PCNXL2 pecanex-like 2 (Drosophila)
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PEG3 paternally expressed 3
PLCD1 phospholipase C, delta 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLXNA2 plexin A2
PMEL premelanosome protein
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRB1 proline-rich protein BstNI subfamily 1
PRKCI protein kinase C, iota
PTCRA pre T-cell antigen receptor alpha
PTGIS prostaglandin I2 (prostacyclin) synthase
RBFA ribosome binding factor A (putative)
RBM12B RNA binding motif protein 12B
REC8 REC8 meiotic recombination protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
REM1 RAS (RAD and GEM)-like GTP-binding 1
RGS12 regulator of G-protein signaling 12
SAFB scaffold attachment factor B
SCN11A sodium channel, voltage gated, type XI alpha subunit
SETD8 SET domain containing (lysine methyltransferase) 8
SH2D2A SH2 domain containing 2A
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SPATA1 spermatogenesis associated 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STX3 syntaxin 3
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
THPO thrombopoietin
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE4 transducin-like enhancer of split 4
TRAPPC9 trafficking protein particle complex 9
TRBC1 T cell receptor beta constant 1
TREX1 three prime repair exonuclease 1
TRIM10 tripartite motif containing 10
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TSPAN9 tetraspanin 9
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
ZNF551 zinc finger protein 551
ZNF614 zinc finger protein 614

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ADM adrenomedullin
AHDC1 AT hook, DNA binding motif, containing 1
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGAP24 Rho GTPase activating protein 24
BAHCC1 BAH domain and coiled-coil containing 1
BBS7 Bardet-Biedl syndrome 7
BIRC7 baculoviral IAP repeat containing 7
BMP15 bone morphogenetic protein 15
BRAF B-Raf proto-oncogene, serine/threonine kinase
C11ORF68 chromosome 11 open reading frame 68
C1QTNF3 C1q and tumor necrosis factor related protein 3
CAPN15 calpain 15
CASD1 CAS1 domain containing 1
CCNL2 cyclin L2
CCP110 centriolar coiled coil protein 110kDa
CDON cell adhesion associated, oncogene regulated
CEP170B centrosomal protein 170B
CHST10 carbohydrate sulfotransferase 10
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLCF1 cardiotrophin-like cytokine factor 1
CLDND1 claudin domain containing 1
CNN2 calponin 2
CRELD1 cysteine-rich with EGF-like domains 1
DAPK3 death-associated protein kinase 3
DBR1 debranching RNA lariats 1
DCAF17 DDB1 and CUL4 associated factor 17
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DYSF dysferlin
EMID1 EMI domain containing 1
EXD3 exonuclease 3'-5' domain containing 3
FAM110B family with sequence similarity 110, member B
FBRS fibrosin
FDXR ferredoxin reductase
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FURIN furin (paired basic amino acid cleaving enzyme)
GPR3 G protein-coupled receptor 3
GRPR gastrin-releasing peptide receptor
GSTT1 glutathione S-transferase theta 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
H1F0 H1 histone family, member 0
HAMP hepcidin antimicrobial peptide
HIST1H2AI histone cluster 1, H2ai
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IGFBP6 insulin-like growth factor binding protein 6
IL4R interleukin 4 receptor
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JMJD4 jumonji domain containing 4
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM8 lysine (K)-specific demethylase 8
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LINC00115 long intergenic non-protein coding RNA 115
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOC729164 hCG1732469
LRRC61 leucine rich repeat containing 61
LTBP2 latent transforming growth factor beta binding protein 2
LZTFL1 leucine zipper transcription factor-like 1
MBTD1 mbt domain containing 1
MCC mutated in colorectal cancers
MTERF4 mitochondrial transcription termination factor 4
MUC3A mucin 3A, cell surface associated
NDE1 nudE neurodevelopment protein 1
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NES nestin
NR1H3 nuclear receptor subfamily 1, group H, member 3
PARP16 poly (ADP-ribose) polymerase family, member 16
PCBP4 poly(rC) binding protein 4
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLD3 phospholipase D family, member 3
POTEKP POTE ankyrin domain family, member K, pseudogene
PTCD2 pentatricopeptide repeat domain 2
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RHBG Rh family, B glycoprotein (gene/pseudogene)
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
STAG3 stromal antigen 3
STIM1 stromal interaction molecule 1
STK16 serine/threonine kinase 16
SYNC syncoilin, intermediate filament protein
TAOK1 TAO kinase 1
TCHH trichohyalin
TET3 tet methylcytosine dioxygenase 3
TFF2 trefoil factor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMEM120B transmembrane protein 120B
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSPYL2 TSPY-like 2
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VIM vimentin
VLDLR very low density lipoprotein receptor
VWA1 von Willebrand factor A domain containing 1
WDR4 WD repeat domain 4
WNT10B wingless-type MMTV integration site family, member 10B
ZC3H12A zinc finger CCCH-type containing 12A
ZNF16 zinc finger protein 16
ZNF442 zinc finger protein 442
ZNF665 zinc finger protein 665
ZNF696 zinc finger protein 696