Prestwick-972-3132 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the Prestwick-972-3132 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABI2 abl-interactor 2
ACVR1B activin A receptor, type IB
AGRN agrin
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ATF7 activating transcription factor 7
ATP9A ATPase, class II, type 9A
BTN2A3P butyrophilin, subfamily 2, member A3, pseudogene
CAMKMT calmodulin-lysine N-methyltransferase
CCDC121 coiled-coil domain containing 121
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL7A1 collagen, type VII, alpha 1
COPE coatomer protein complex, subunit epsilon
CXCL3 chemokine (C-X-C motif) ligand 3
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DOK3 docking protein 3
DSTYK dual serine/threonine and tyrosine protein kinase
E2F5 E2F transcription factor 5, p130-binding
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EHD1 EH-domain containing 1
ENG endoglin
EPHB3 EPH receptor B3
EPHB4 EPH receptor B4
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
F12 coagulation factor XII (Hageman factor)
FADS3 fatty acid desaturase 3
FGF5 fibroblast growth factor 5
FN1 fibronectin 1
FOXG1 forkhead box G1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRMD4B FERM domain containing 4B
FUBP1 far upstream element (FUSE) binding protein 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GATA3 GATA binding protein 3
GLG1 golgi glycoprotein 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
HDAC7 histone deacetylase 7
HLA-F major histocompatibility complex, class I, F
HOXA1 homeobox A1
HOXC8 homeobox C8
HRH3 histamine receptor H3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IRX4 iroquois homeobox 4
KIAA0319L KIAA0319-like
KRT31 keratin 31, type I
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LINC01558 long intergenic non-protein coding RNA 1558
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRP2 low density lipoprotein receptor-related protein 2
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP2K6 mitogen-activated protein kinase kinase 6
MBNL3 muscleblind-like splicing regulator 3
METTL7A methyltransferase like 7A
MISP mitotic spindle positioning
MPDZ multiple PDZ domain protein
MTL5 metallothionein-like 5, testis-specific (tesmin)
MZF1 myeloid zinc finger 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
NR6A1 nuclear receptor subfamily 6, group A, member 1
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PBX2 pre-B-cell leukemia homeobox 2
PCDH17 protocadherin 17
PCGF2 polycomb group ring finger 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE4DIP phosphodiesterase 4D interacting protein
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PPAP2B phosphatidic acid phosphatase type 2B
PPARD peroxisome proliferator-activated receptor delta
PTGDS prostaglandin D2 synthase 21kDa (brain)
RECQL5 RecQ protein-like 5
SCAND2P SCAN domain containing 2 pseudogene
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC1 syndecan 1
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SIX3 SIX homeobox 3
SLC39A9 solute carrier family 39, member 9
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPG20 spastic paraplegia 20 (Troyer syndrome)
SRCAP Snf2-related CREBBP activator protein
SSH3 slingshot protein phosphatase 3
STAB2 stabilin 2
SYNDIG1 synapse differentiation inducing 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TDO2 tryptophan 2,3-dioxygenase
THRB thyroid hormone receptor, beta
TICAM1 toll-like receptor adaptor molecule 1
TPMT thiopurine S-methyltransferase
TRBC1 T cell receptor beta constant 1
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TTLL7 tubulin tyrosine ligase-like family member 7
UBE3A ubiquitin protein ligase E3A
UNC119 unc-119 homolog (C. elegans)
ZNF407 zinc finger protein 407

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
BIRC3 baculoviral IAP repeat containing 3
BTN3A1 butyrophilin, subfamily 3, member A1
C14ORF93 chromosome 14 open reading frame 93
C1ORF105 chromosome 1 open reading frame 105
CDHR2 cadherin-related family member 2
CLIP2 CAP-GLY domain containing linker protein 2
CORT cortistatin
CPEB3 cytoplasmic polyadenylation element binding protein 3
CXCL2 chemokine (C-X-C motif) ligand 2
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DCSTAMP dendrocyte expressed seven transmembrane protein
DGKG diacylglycerol kinase, gamma 90kDa
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAL4 dynein, axonemal, light chain 4
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
ENO3 enolase 3 (beta, muscle)
EPX eosinophil peroxidase
ERCC2 excision repair cross-complementation group 2
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
FBXL6 F-box and leucine-rich repeat protein 6
FLRT1 fibronectin leucine rich transmembrane protein 1
FOXO4 forkhead box O4
FRS3 fibroblast growth factor receptor substrate 3
GAA glucosidase, alpha; acid
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPATCH2L G patch domain containing 2-like
GPR3 G protein-coupled receptor 3
GSK3A glycogen synthase kinase 3 alpha
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GTPBP6 GTP binding protein 6 (putative)
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2AE histone cluster 1, H2ae
HIST1H2AI histone cluster 1, H2ai
HLA-DMB major histocompatibility complex, class II, DM beta
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INF2 inverted formin, FH2 and WH2 domain containing
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KPTN kaptin (actin binding protein)
LRRK1 leucine-rich repeat kinase 1
LTBP2 latent transforming growth factor beta binding protein 2
LTBP3 latent transforming growth factor beta binding protein 3
MCRS1 microspherule protein 1
MYH15 myosin, heavy chain 15
MYOZ1 myozenin 1
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NBEA neurobeachin
NINJ2 ninjurin 2
NT5M 5',3'-nucleotidase, mitochondrial
NTSR1 neurotensin receptor 1 (high affinity)
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OXTR oxytocin receptor
PARG poly (ADP-ribose) glycohydrolase
PCDHGB5 protocadherin gamma subfamily B, 5
PDGFRL platelet-derived growth factor receptor-like
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PID1 phosphotyrosine interaction domain containing 1
PIEZO1 piezo-type mechanosensitive ion channel component 1
PODNL1 podocan-like 1
POLL polymerase (DNA directed), lambda
RANBP17 RAN binding protein 17
RAP1GAP2 RAP1 GTPase activating protein 2
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RHOB ras homolog family member B
RNF122 ring finger protein 122
S1PR4 sphingosine-1-phosphate receptor 4
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SLC12A9 solute carrier family 12, member 9
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC39A4 solute carrier family 39 (zinc transporter), member 4
ST7L suppression of tumorigenicity 7 like
STRN striatin, calmodulin binding protein
TAS2R1 taste receptor, type 2, member 1
TERT telomerase reverse transcriptase
TIAM2 T-cell lymphoma invasion and metastasis 2
TMEM212 transmembrane protein 212
TONSL tonsoku-like, DNA repair protein
TRAF2 TNF receptor-associated factor 2
TSNAXIP1 translin-associated factor X interacting protein 1
TSPAN32 tetraspanin 32
VN1R1 vomeronasal 1 receptor 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR62 WD repeat domain 62
WNT16 wingless-type MMTV integration site family, member 16
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZIM2 zinc finger, imprinted 2
ZNF225 zinc finger protein 225
ZNF254 zinc finger protein 254
ZNF408 zinc finger protein 408
ZNF668 zinc finger protein 668
ZNF768 zinc finger protein 768
ZNF816 zinc finger protein 816