Prestwick-967-4833 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the Prestwick-967-4833 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM23 ADAM metallopeptidase domain 23
AKAP1 A kinase (PRKA) anchor protein 1
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARMCX2 armadillo repeat containing, X-linked 2
ASPH aspartate beta-hydroxylase
BGN biglycan
BMP4 bone morphogenetic protein 4
BMP5 bone morphogenetic protein 5
BTF3P11 basic transcription factor 3 pseudogene 11
BTN3A1 butyrophilin, subfamily 3, member A1
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBX8 chromobox homolog 8
CD22 CD22 molecule
CDC25C cell division cycle 25C
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTIF CBP80/20-dependent translation initiation factor
DMXL2 Dmx-like 2
DOCK6 dedicator of cytokinesis 6
EDN1 endothelin 1
EFNA3 ephrin-A3
EGR3 early growth response 3
ELSPBP1 epididymal sperm binding protein 1
ESR1 estrogen receptor 1
GNB5 guanine nucleotide binding protein (G protein), beta 5
GOLGA2 golgin A2
HELZ helicase with zinc finger
HIST1H3I histone cluster 1, H3i
IDS iduronate 2-sulfatase
IL17RA interleukin 17 receptor A
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA6 integrin, alpha 6
JAK2 Janus kinase 2
KHSRP KH-type splicing regulatory protein
KRT16 keratin 16, type I
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAPK11 mitogen-activated protein kinase 11
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEGF6 multiple EGF-like-domains 6
MFSD11 major facilitator superfamily domain containing 11
MFSD12 major facilitator superfamily domain containing 12
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MMP3 matrix metallopeptidase 3
MST1 macrophage stimulating 1
MTMR3 myotubularin related protein 3
MUC1 mucin 1, cell surface associated
NFIB nuclear factor I/B
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFX1 nuclear transcription factor, X-box binding 1
NME5 NME/NM23 family member 5
NR1H4 nuclear receptor subfamily 1, group H, member 4
NRG1 neuregulin 1
OR2F2 olfactory receptor, family 2, subfamily F, member 2
PCDH1 protocadherin 1
PDCD11 programmed cell death 11
PDLIM2 PDZ and LIM domain 2 (mystique)
PEX1 peroxisomal biogenesis factor 1
PILRA paired immunoglobin-like type 2 receptor alpha
PLXND1 plexin D1
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
POLM polymerase (DNA directed), mu
POMT2 protein-O-mannosyltransferase 2
PXDC1 PX domain containing 1
QKI QKI, KH domain containing, RNA binding
RAB36 RAB36, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RARA retinoic acid receptor, alpha
RBP4 retinol binding protein 4, plasma
RET ret proto-oncogene
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SCN10A sodium channel, voltage gated, type X alpha subunit
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC38A7 solute carrier family 38, member 7
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMG7 SMG7 nonsense mediated mRNA decay factor
SNX13 sorting nexin 13
SPTBN1 spectrin, beta, non-erythrocytic 1
SPTBN2 spectrin, beta, non-erythrocytic 2
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TCF3 transcription factor 3
TCOF1 Treacher Collins-Franceschetti syndrome 1
TFEB transcription factor EB
TMPRSS2 transmembrane protease, serine 2
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRIM21 tripartite motif containing 21
TTLL4 tubulin tyrosine ligase-like family member 4
UTRN utrophin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WWOX WW domain containing oxidoreductase
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACPP acid phosphatase, prostate
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ANXA2P3 annexin A2 pseudogene 3
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATAT1 alpha tubulin acetyltransferase 1
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C11ORF63 chromosome 11 open reading frame 63
C1ORF105 chromosome 1 open reading frame 105
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C8ORF60 chromosome 8 open reading frame 60
CAPN5 calpain 5
CCDC132 coiled-coil domain containing 132
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDK3 cyclin-dependent kinase 3
CHST10 carbohydrate sulfotransferase 10
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
COPZ2 coatomer protein complex, subunit zeta 2
CORT cortistatin
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
EIF5A2 eukaryotic translation initiation factor 5A2
EML4 echinoderm microtubule associated protein like 4
ERCC2 excision repair cross-complementation group 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EVA1B eva-1 homolog B (C. elegans)
F3 coagulation factor III (thromboplastin, tissue factor)
FAM118A family with sequence similarity 118, member A
FAM120C family with sequence similarity 120C
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FLCN folliculin
FLJ21369 uncharacterized protein FLJ21369
FOXN2 forkhead box N2
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GEMIN8 gem (nuclear organelle) associated protein 8
GMPR guanosine monophosphate reductase
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2AK histone cluster 1, H2ak
HIST1H2AL histone cluster 1, H2al
HIST1H2AM histone cluster 1, H2am
HIST1H4A histone cluster 1, H4a
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMOX1 heme oxygenase 1
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HYI hydroxypyruvate isomerase (putative)
IDI2-AS1 IDI2 antisense RNA 1
IFT140 intraflagellar transport 140
KCTD20 potassium channel tetramerization domain containing 20
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KREMEN2 kringle containing transmembrane protein 2
LAX1 lymphocyte transmembrane adaptor 1
LOXL3 lysyl oxidase-like 3
LZTFL1 leucine zipper transcription factor-like 1
MEFV Mediterranean fever
MRPL41 mitochondrial ribosomal protein L41
MRPL52 mitochondrial ribosomal protein L52
MTSS1L metastasis suppressor 1-like
MUC3B mucin 3B, cell surface associated
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NCAM2 neural cell adhesion molecule 2
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NEK3 NIMA-related kinase 3
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OLFML2A olfactomedin-like 2A
PCDHB8 protocadherin beta 8
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
POLL polymerase (DNA directed), lambda
PRF1 perforin 1 (pore forming protein)
PRSS53 protease, serine, 53
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RNF2 ring finger protein 2
SCAI suppressor of cancer cell invasion
SCGB2A2 secretoglobin, family 2A, member 2
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SLC12A8 solute carrier family 12, member 8
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SMR3A submaxillary gland androgen regulated protein 3A
SPON2 spondin 2, extracellular matrix protein
TEX40 testis expressed 40
TMEM184C transmembrane protein 184C
TPK1 thiamin pyrophosphokinase 1
UBQLN4 ubiquilin 4
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
UPK2 uroplakin 2
VASH2 vasohibin 2
XYLT2 xylosyltransferase II
ZC3H3 zinc finger CCCH-type containing 3
ZNF137P zinc finger protein 137, pseudogene
ZNF180 zinc finger protein 180
ZNF280D zinc finger protein 280D