Prestwick-967-4250 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the Prestwick-967-4250 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APOH apolipoprotein H (beta-2-glycoprotein I)
ASTN2 astrotactin 2
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BCL2 B-cell CLL/lymphoma 2
C10ORF10 chromosome 10 open reading frame 10
C17ORF59 chromosome 17 open reading frame 59
C1S complement component 1, s subcomponent
CASC1 cancer susceptibility candidate 1
CCDC181 coiled-coil domain containing 181
CD79A CD79a molecule, immunoglobulin-associated alpha
CDC14A cell division cycle 14A
CLUAP1 clusterin associated protein 1
CNTN1 contactin 1
CNTNAP2 contactin associated protein-like 2
CRAT carnitine O-acetyltransferase
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CTSS cathepsin S
CXCL5 chemokine (C-X-C motif) ligand 5
DPF1 D4, zinc and double PHD fingers family 1
DTNA dystrobrevin, alpha
EDA ectodysplasin A
EFR3B EFR3 homolog B (S. cerevisiae)
EGFR epidermal growth factor receptor
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENG endoglin
ESRRG estrogen-related receptor gamma
EZR ezrin
FAM63A family with sequence similarity 63, member A
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FLJ11710 uncharacterized protein FLJ11710
FRS2 fibroblast growth factor receptor substrate 2
FZD10 frizzled class receptor 10
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GPR161 G protein-coupled receptor 161
GSPT1 G1 to S phase transition 1
GSTCD glutathione S-transferase, C-terminal domain containing
GUCA1B guanylate cyclase activator 1B (retina)
HAP1 huntingtin-associated protein 1
HEG1 heart development protein with EGF-like domains 1
HIST1H1E histone cluster 1, H1e
HIST1H4C histone cluster 1, H4c
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
ICA1 islet cell autoantigen 1, 69kDa
IGHM immunoglobulin heavy constant mu
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL12B interleukin 12B
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
MAN1A2 mannosidase, alpha, class 1A, member 2
MMP3 matrix metallopeptidase 3
MYH14 myosin, heavy chain 14, non-muscle
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NF1 neurofibromin 1
NME5 NME/NM23 family member 5
NNMT nicotinamide N-methyltransferase
NOS1 nitric oxide synthase 1 (neuronal)
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
OTOR otoraplin
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PGLYRP1 peptidoglycan recognition protein 1
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PNMAL1 paraneoplastic Ma antigen family-like 1
POU5F1P3 POU class 5 homeobox 1 pseudogene 3
PPARD peroxisome proliferator-activated receptor delta
PTK2B protein tyrosine kinase 2 beta
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTPRR protein tyrosine phosphatase, receptor type, R
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RGS5 regulator of G-protein signaling 5
RHO rhodopsin
RNF32 ring finger protein 32
RPL23AP53 ribosomal protein L23a pseudogene 53
RPS14 ribosomal protein S14
RPS3A ribosomal protein S3A
RUNX3 runt-related transcription factor 3
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLAMF7 SLAM family member 7
SPPL2B signal peptide peptidase like 2B
SPTB spectrin, beta, erythrocytic
SSTR5 somatostatin receptor 5
ST7L suppression of tumorigenicity 7 like
TAPBPL TAP binding protein-like
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
VWA5A von Willebrand factor A domain containing 5A
WDR4 WD repeat domain 4
WDR62 WD repeat domain 62
ZIM2 zinc finger, imprinted 2
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZMAT5 zinc finger, matrin-type 5
ZNF225 zinc finger protein 225
ZNF695 zinc finger protein 695

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ADAM2 ADAM metallopeptidase domain 2
ADGRB2 adhesion G protein-coupled receptor B2
ALOX12 arachidonate 12-lipoxygenase
APOC4 apolipoprotein C-IV
ARMCX2 armadillo repeat containing, X-linked 2
C22ORF46 chromosome 22 open reading frame 46
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CD68 CD68 molecule
CDHR2 cadherin-related family member 2
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CNOT3 CCR4-NOT transcription complex, subunit 3
COMP cartilage oligomeric matrix protein
CSF1R colony stimulating factor 1 receptor
CXORF21 chromosome X open reading frame 21
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
EFCAB2 EF-hand calcium binding domain 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FKBP5 FK506 binding protein 5
FLT4 fms-related tyrosine kinase 4
FRMPD1 FERM and PDZ domain containing 1
FRS3 fibroblast growth factor receptor substrate 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR75 G protein-coupled receptor 75
GRM4 glutamate receptor, metabotropic 4
HIST1H2AK histone cluster 1, H2ak
HIST1H2BN histone cluster 1, H2bn
HIST1H3F histone cluster 1, H3f
HPR haptoglobin-related protein
IL36RN interleukin 36 receptor antagonist
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIAA1456 KIAA1456
KLF13 Kruppel-like factor 13
KRT34 keratin 34, type I
LATS1 large tumor suppressor kinase 1
LENEP lens epithelial protein
LIME1 Lck interacting transmembrane adaptor 1
LINC00260 long intergenic non-protein coding RNA 260
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOC100287590 uncharacterized LOC100287590
LPAR4 lysophosphatidic acid receptor 4
LY6G6C lymphocyte antigen 6 complex, locus G6C
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MFGE8 milk fat globule-EGF factor 8 protein
MGP matrix Gla protein
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MID1IP1 MID1 interacting protein 1
MMP13 matrix metallopeptidase 13
MTA2 metastasis associated 1 family, member 2
MTSS1L metastasis suppressor 1-like
MYL9 myosin, light chain 9, regulatory
NTSR1 neurotensin receptor 1 (high affinity)
NXPE3 neurexophilin and PC-esterase domain family, member 3
ODF2 outer dense fiber of sperm tails 2
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSBP2 oxysterol binding protein 2
PAIP2B poly(A) binding protein interacting protein 2B
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLBD1 phospholipase B domain containing 1
POLL polymerase (DNA directed), lambda
PRB3 proline-rich protein BstNI subfamily 3
PRKG2 protein kinase, cGMP-dependent, type II
PRM2 protamine 2
PRPH peripherin
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
REM1 RAS (RAD and GEM)-like GTP-binding 1
RGCC regulator of cell cycle
RNF122 ring finger protein 122
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SIX3 SIX homeobox 3
SLC16A6 solute carrier family 16, member 6
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMR3A submaxillary gland androgen regulated protein 3A
SPTBN2 spectrin, beta, non-erythrocytic 2
SSBP3 single stranded DNA binding protein 3
STAG3 stromal antigen 3
STIM1 stromal interaction molecule 1
STRN striatin, calmodulin binding protein
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TIGD6 tigger transposable element derived 6
TLN1 talin 1
TNS2 tensin 2
TSNAXIP1 translin-associated factor X interacting protein 1
USP20 ubiquitin specific peptidase 20
WNT1 wingless-type MMTV integration site family, member 1
ZNF358 zinc finger protein 358