Prestwick-967-2925 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the Prestwick-967-2925 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADCK2 aarF domain containing kinase 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
B3GAT1 beta-1,3-glucuronyltransferase 1
C6ORF47 chromosome 6 open reading frame 47
CA8 carbonic anhydrase VIII
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCDC132 coiled-coil domain containing 132
CDC14B cell division cycle 14B
CECR1 cat eye syndrome chromosome region, candidate 1
CLCN4 chloride channel, voltage-sensitive 4
CNOT4 CCR4-NOT transcription complex, subunit 4
CNR2 cannabinoid receptor 2 (macrophage)
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DMC1 DNA meiotic recombinase 1
DOCK6 dedicator of cytokinesis 6
DSPP dentin sialophosphoprotein
E2F1 E2F transcription factor 1
EGR4 early growth response 4
EHD1 EH-domain containing 1
FAM163A family with sequence similarity 163, member A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FCAR Fc fragment of IgA receptor
FCHO1 FCH domain only 1
FLT4 fms-related tyrosine kinase 4
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FSTL3 follistatin-like 3 (secreted glycoprotein)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GLI3 GLI family zinc finger 3
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GRIK5 glutamate receptor, ionotropic, kainate 5
GSK3A glycogen synthase kinase 3 alpha
HDAC11 histone deacetylase 11
HDAC6 histone deacetylase 6
HLA-DMB major histocompatibility complex, class II, DM beta
HNF1B HNF1 homeobox B
IGLL1 immunoglobulin lambda-like polypeptide 1
IL2RB interleukin 2 receptor, beta
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KIAA0226L KIAA0226-like
KLK2 kallikrein-related peptidase 2
KRIT1 KRIT1, ankyrin repeat containing
KRT81 keratin 81, type II
LAMB3 laminin, beta 3
LDLR low density lipoprotein receptor
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRRC15 leucine rich repeat containing 15
MAL mal, T-cell differentiation protein
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MED25 mediator complex subunit 25
MET MET proto-oncogene, receptor tyrosine kinase
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MLXIP MLX interacting protein
MRPL20 mitochondrial ribosomal protein L20
MRPS18C mitochondrial ribosomal protein S18C
NNAT neuronatin
NOX4 NADPH oxidase 4
OGFR opioid growth factor receptor
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RASL11B RAS-like, family 11, member B
RGS5 regulator of G-protein signaling 5
RPH3A rabphilin 3A
RPL37A ribosomal protein L37a
RRBP1 ribosome binding protein 1
RUNX1 runt-related transcription factor 1
SAMD4A sterile alpha motif domain containing 4A
SHANK1 SH3 and multiple ankyrin repeat domains 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SORBS3 sorbin and SH3 domain containing 3
SRRM2 serine/arginine repetitive matrix 2
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
STYK1 serine/threonine/tyrosine kinase 1
SULT4A1 sulfotransferase family 4A, member 1
TBCD tubulin folding cofactor D
TBX2 T-box 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB1 transforming growth factor, beta 1
TIMELESS timeless circadian clock
TM4SF20 transmembrane 4 L six family member 20
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TSC22D2 TSC22 domain family, member 2
TSKS testis-specific serine kinase substrate
TSPAN9 tetraspanin 9
VAV2 vav 2 guanine nucleotide exchange factor
VDAC3 voltage-dependent anion channel 3
ZFPL1 zinc finger protein-like 1
ZNF688 zinc finger protein 688
ZNF747 zinc finger protein 747

decreased expression

Symbol Name
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACPP acid phosphatase, prostate
ANO10 anoctamin 10
APOL6 apolipoprotein L, 6
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATF6 activating transcription factor 6
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BIRC3 baculoviral IAP repeat containing 3
C11ORF21 chromosome 11 open reading frame 21
C11ORF30 chromosome 11 open reading frame 30
C5 complement component 5
CBY1 chibby homolog 1 (Drosophila)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
DENND2D DENN/MADD domain containing 2D
DGAT1 diacylglycerol O-acyltransferase 1
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNMBP dynamin binding protein
DTWD1 DTW domain containing 1
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EGR2 early growth response 2
EGR3 early growth response 3
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM188A family with sequence similarity 188, member A
FAM3C family with sequence similarity 3, member C
FANCF Fanconi anemia, complementation group F
FBXL6 F-box and leucine-rich repeat protein 6
FES FES proto-oncogene, tyrosine kinase
GCH1 GTP cyclohydrolase 1
GK3P glycerol kinase 3 pseudogene
GMEB1 glucocorticoid modulatory element binding protein 1
GUSBP3 glucuronidase, beta pseudogene 3
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HOXA1 homeobox A1
HOXA5 homeobox A5
HYAL3 hyaluronoglucosaminidase 3
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
INF2 inverted formin, FH2 and WH2 domain containing
INHBE inhibin, beta E
IP6K1 inositol hexakisphosphate kinase 1
ISOC2 isochorismatase domain containing 2
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KPTN kaptin (actin binding protein)
LIMD2 LIM domain containing 2
LOC157562 uncharacterized LOC157562
LRRK1 leucine-rich repeat kinase 1
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MIR22HG MIR22 host gene
MRPL28 mitochondrial ribosomal protein L28
MYH15 myosin, heavy chain 15
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NT5M 5',3'-nucleotidase, mitochondrial
PARPBP PARP1 binding protein
PITX2 paired-like homeodomain 2
PLEKHA5 pleckstrin homology domain containing, family A member 5
PSKH1 protein serine kinase H1
PTH2R parathyroid hormone 2 receptor
PWAR5 Prader Willi/Angelman region RNA 5
PYGB phosphorylase, glycogen; brain
RGS19 regulator of G-protein signaling 19
RNF31 ring finger protein 31
RPAP1 RNA polymerase II associated protein 1
SAMD9 sterile alpha motif domain containing 9
SCAI suppressor of cancer cell invasion
SERGEF secretion regulating guanine nucleotide exchange factor
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SKI SKI proto-oncogene
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNHG20 small nucleolar RNA host gene 20
SOCS6 suppressor of cytokine signaling 6
SSFA2 sperm specific antigen 2
THAP10 THAP domain containing 10
TMEM104 transmembrane protein 104
TNNT1 troponin T type 1 (skeletal, slow)
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TROAP trophinin associated protein
TTF2 transcription termination factor, RNA polymerase II
UPP1 uridine phosphorylase 1
VCPKMT valosin containing protein lysine (K) methyltransferase
ZMAT3 zinc finger, matrin-type 3
ZNF250 zinc finger protein 250
ZNF254 zinc finger protein 254
ZNF280D zinc finger protein 280D
ZNF665 zinc finger protein 665
ZNF667 zinc finger protein 667
ZNF804A zinc finger protein 804A