Prestwick-920-5056 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the Prestwick-920-5056 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
AIM1L absent in melanoma 1-like
AKAP8L A kinase (PRKA) anchor protein 8-like
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
APAF1 apoptotic peptidase activating factor 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGAP35 Rho GTPase activating protein 35
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
C10ORF12 chromosome 10 open reading frame 12
CCDC57 coiled-coil domain containing 57
COL1A2 collagen, type I, alpha 2
CST4 cystatin S
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
DFNB31 deafness, autosomal recessive 31
DNAAF1 dynein, axonemal, assembly factor 1
DOCK10 dedicator of cytokinesis 10
DUSP9 dual specificity phosphatase 9
EYA4 EYA transcriptional coactivator and phosphatase 4
FBXO2 F-box protein 2
FGB fibrinogen beta chain
FGF18 fibroblast growth factor 18
FGF3 fibroblast growth factor 3
FGL1 fibrinogen-like 1
FUBP1 far upstream element (FUSE) binding protein 1
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3
GAS2L1 growth arrest-specific 2 like 1
GFER growth factor, augmenter of liver regeneration
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPATCH4 G patch domain containing 4
GPR21 G protein-coupled receptor 21
GSK3A glycogen synthase kinase 3 alpha
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOXC4 homeobox C4
IGLL1 immunoglobulin lambda-like polypeptide 1
IL2RA interleukin 2 receptor, alpha
ING2 inhibitor of growth family, member 2
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KLK7 kallikrein-related peptidase 7
KYNU kynureninase
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LMNA lamin A/C
LOC399491
LOC57399 uncharacterized gastric protein ZA52P
LRRC2 leucine rich repeat containing 2
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MINK1 misshapen-like kinase 1
MMP13 matrix metallopeptidase 13
MTSS1L metastasis suppressor 1-like
MUC1 mucin 1, cell surface associated
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NF1 neurofibromin 1
OMD osteomodulin
ONECUT2 one cut homeobox 2
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PAOX polyamine oxidase (exo-N4-amino)
PARVA parvin, alpha
PEAK1 pseudopodium-enriched atypical kinase 1
PHLDB1 pleckstrin homology-like domain, family B, member 1
PICK1 protein interacting with PRKCA 1
PID1 phosphotyrosine interaction domain containing 1
PLD1 phospholipase D1, phosphatidylcholine-specific
PLG plasminogen
PLXNC1 plexin C1
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
POU2F2 POU class 2 homeobox 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PQLC2 PQ loop repeat containing 2
PRDX2 peroxiredoxin 2
PRX periaxin
PTPRH protein tyrosine phosphatase, receptor type, H
PTPRR protein tyrosine phosphatase, receptor type, R
PTPRU protein tyrosine phosphatase, receptor type, U
RECQL5 RecQ protein-like 5
RGS6 regulator of G-protein signaling 6
RIN3 Ras and Rab interactor 3
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNF122 ring finger protein 122
RNF43 ring finger protein 43
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLIT1 slit homolog 1 (Drosophila)
SPI1 Spi-1 proto-oncogene
SPN sialophorin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TBX1 T-box 1
TCP11 t-complex 11, testis-specific
TMEM19 transmembrane protein 19
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TTC22 tetratricopeptide repeat domain 22
WDR55 WD repeat domain 55
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
ACSL4 acyl-CoA synthetase long-chain family member 4
ANAPC10 anaphase promoting complex subunit 10
ANXA10 annexin A10
ARHGAP24 Rho GTPase activating protein 24
ARL14 ADP-ribosylation factor-like 14
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BCL2L2 BCL2-like 2
BCL9 B-cell CLL/lymphoma 9
BRIX1 BRX1, biogenesis of ribosomes
C17ORF75 chromosome 17 open reading frame 75
C21ORF91 chromosome 21 open reading frame 91
CCP110 centriolar coiled coil protein 110kDa
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD82 CD82 molecule
CGREF1 cell growth regulator with EF-hand domain 1
CLCN5 chloride channel, voltage-sensitive 5
CLDN1 claudin 1
CLDN14 claudin 14
CNN1 calponin 1, basic, smooth muscle
CRYBA2 crystallin, beta A2
CTSK cathepsin K
CXCL3 chemokine (C-X-C motif) ligand 3
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DAZAP1 DAZ associated protein 1
DCAF17 DDB1 and CUL4 associated factor 17
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
EHD3 EH-domain containing 3
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM120C family with sequence similarity 120C
FAM204A family with sequence similarity 204, member A
FANCE Fanconi anemia, complementation group E
FANCF Fanconi anemia, complementation group F
FRS3 fibroblast growth factor receptor substrate 3
GALT galactose-1-phosphate uridylyltransferase
GPALPP1 GPALPP motifs containing 1
GPC3 glypican 3
GTF2I general transcription factor IIi
HIST1H2AM histone cluster 1, H2am
HIST1H2BC histone cluster 1, H2bc
HOXA4 homeobox A4
IFI6 interferon, alpha-inducible protein 6
ISYNA1 inositol-3-phosphate synthase 1
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KRT4 keratin 4, type II
KRT75 keratin 75, type II
LATS1 large tumor suppressor kinase 1
LYRM2 LYR motif containing 2
MAGEH1 melanoma antigen family H1
MAPK12 mitogen-activated protein kinase 12
MFSD6 major facilitator superfamily domain containing 6
MGP matrix Gla protein
MOB3B MOB kinase activator 3B
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPS15 mitochondrial ribosomal protein S15
MSL2 male-specific lethal 2 homolog (Drosophila)
MTRF1 mitochondrial translational release factor 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPM3 nucleophosmin/nucleoplasmin 3
NUP62CL nucleoporin 62kDa C-terminal like
OSBP2 oxysterol binding protein 2
PARM1 prostate androgen-regulated mucin-like protein 1
PCOLCE procollagen C-endopeptidase enhancer
PERP PERP, TP53 apoptosis effector
PHKG2 phosphorylase kinase, gamma 2 (testis)
PHLDA3 pleckstrin homology-like domain, family A, member 3
PRKCE protein kinase C, epsilon
PRR7 proline rich 7 (synaptic)
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RNF39 ring finger protein 39
SETMAR SET domain and mariner transposase fusion gene
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC35F6 solute carrier family 35, member F6
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLITRK5 SLIT and NTRK-like family, member 5
SRD5A3 steroid 5 alpha-reductase 3
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBX19 T-box 19
TMC7 transmembrane channel-like 7
TMEM209 transmembrane protein 209
TMEM254 transmembrane protein 254
TMEM51 transmembrane protein 51
TMOD3 tropomodulin 3 (ubiquitous)
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TSC22D4 TSC22 domain family, member 4
TTBK2 tau tubulin kinase 2
USP18 ubiquitin specific peptidase 18
USP19 ubiquitin specific peptidase 19
YAF2 YY1 associated factor 2
ZBTB6 zinc finger and BTB domain containing 6
ZC3H12A zinc finger CCCH-type containing 12A
ZFP69B ZFP69 zinc finger protein B
ZNF204P zinc finger protein 204, pseudogene
ZNF571 zinc finger protein 571