Prestwick-857-6635 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the Prestwick-857-6635 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
AFF3 AF4/FMR2 family, member 3
AHDC1 AT hook, DNA binding motif, containing 1
AREG amphiregulin
ARMC4 armadillo repeat containing 4
ATF7IP activating transcription factor 7 interacting protein
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCL2 B-cell CLL/lymphoma 2
BGN biglycan
BTG2 BTG family, member 2
C1ORF54 chromosome 1 open reading frame 54
CD58 CD58 molecule
CD6 CD6 molecule
CDK20 cyclin-dependent kinase 20
CELF2 CUGBP, Elav-like family member 2
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DCN decorin
DLX4 distal-less homeobox 4
DUSP2 dual specificity phosphatase 2
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EFCAB11 EF-hand calcium binding domain 11
EPYC epiphycan
FGF1 fibroblast growth factor 1 (acidic)
FILIP1L filamin A interacting protein 1-like
FOXO1 forkhead box O1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GFI1 growth factor independent 1 transcription repressor
GMEB1 glucocorticoid modulatory element binding protein 1
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HBE1 hemoglobin, epsilon 1
HDAC6 histone deacetylase 6
HFE hemochromatosis
HLA-DOA major histocompatibility complex, class II, DO alpha
HOXA1 homeobox A1
HPSE2 heparanase 2 (inactive)
HSF2BP heat shock transcription factor 2 binding protein
HSPB6 heat shock protein, alpha-crystallin-related, B6
ICOSLG inducible T-cell co-stimulator ligand
IFT122 intraflagellar transport 122
ING4 inhibitor of growth family, member 4
IRX4 iroquois homeobox 4
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KLF12 Kruppel-like factor 12
KRT33A keratin 33A, type I
LAMC2 laminin, gamma 2
LIME1 Lck interacting transmembrane adaptor 1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC48 leucine rich repeat containing 48
LTBP4 latent transforming growth factor beta binding protein 4
MCF2L MCF.2 cell line derived transforming sequence-like
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MOCS1 molybdenum cofactor synthesis 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTCP1 mature T-cell proliferation 1
NDNF neuron-derived neurotrophic factor
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
PAPPA2 pappalysin 2
PCDHB17P protocadherin beta 17 pseudogene
PDE4DIP phosphodiesterase 4D interacting protein
PDPN podoplanin
PHF20 PHD finger protein 20
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIDD1 p53-induced death domain protein 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PML promyelocytic leukemia
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RARB retinoic acid receptor, beta
RGS14 regulator of G-protein signaling 14
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMC1A structural maintenance of chromosomes 1A
SORBS2 sorbin and SH3 domain containing 2
SOS2 son of sevenless homolog 2 (Drosophila)
SPRED2 sprouty-related, EVH1 domain containing 2
STS steroid sulfatase (microsomal), isozyme S
SYNJ1 synaptojanin 1
TAOK2 TAO kinase 2
TBCD tubulin folding cofactor D
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TCP10 t-complex 10
TCP10L t-complex 10-like
TLK1 tousled-like kinase 1
TLR2 toll-like receptor 2
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TPM3 tropomyosin 3
USP46 ubiquitin specific peptidase 46
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WWOX WW domain containing oxidoreductase
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XDH xanthine dehydrogenase
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZC3H7B zinc finger CCCH-type containing 7B
ZNF24 zinc finger protein 24
ZNF440 zinc finger protein 440
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ADTRP androgen-dependent TFPI-regulating protein
AMT aminomethyltransferase
ANXA2P1 annexin A2 pseudogene 1
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ATF7IP2 activating transcription factor 7 interacting protein 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
C14ORF79 chromosome 14 open reading frame 79
C4ORF29 chromosome 4 open reading frame 29
C5ORF45 chromosome 5 open reading frame 45
C7ORF43 chromosome 7 open reading frame 43
CAMKMT calmodulin-lysine N-methyltransferase
CAPN15 calpain 15
CCDC85C coiled-coil domain containing 85C
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CFHR2 complement factor H-related 2
CIDEB cell death-inducing DFFA-like effector b
CISH cytokine inducible SH2-containing protein
CNGB3 cyclic nucleotide gated channel beta 3
CPED1 cadherin-like and PC-esterase domain containing 1
CXCL3 chemokine (C-X-C motif) ligand 3
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DFNB31 deafness, autosomal recessive 31
DHDDS dehydrodolichyl diphosphate synthase
DSPP dentin sialophosphoprotein
DUSP8 dual specificity phosphatase 8
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EFNA3 ephrin-A3
ERCC4 excision repair cross-complementation group 4
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FBXL7 F-box and leucine-rich repeat protein 7
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GAS8 growth arrest-specific 8
GINS4 GINS complex subunit 4 (Sld5 homolog)
GRAMD1C GRAM domain containing 1C
GUSBP3 glucuronidase, beta pseudogene 3
HAMP hepcidin antimicrobial peptide
HDAC9 histone deacetylase 9
HIST1H1D histone cluster 1, H1d
IL2 interleukin 2
KIAA0319L KIAA0319-like
KIAA0922 KIAA0922
KLC2 kinesin light chain 2
KLHL4 kelch-like family member 4
KRT20 keratin 20, type I
KRT6A keratin 6A, type II
LRRC37A3 leucine rich repeat containing 37, member A3
LTC4S leukotriene C4 synthase
MCC mutated in colorectal cancers
MDFI MyoD family inhibitor
MDM4 MDM4, p53 regulator
MFSD12 major facilitator superfamily domain containing 12
MOB3B MOB kinase activator 3B
MOCS3 molybdenum cofactor synthesis 3
MYL9 myosin, light chain 9, regulatory
MYOZ3 myozenin 3
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NKX3-2 NK3 homeobox 2
NME5 NME/NM23 family member 5
NUP62CL nucleoporin 62kDa C-terminal like
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PAIP2B poly(A) binding protein interacting protein 2B
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PICK1 protein interacting with PRKCA 1
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLAC8 placenta-specific 8
PLEKHO1 pleckstrin homology domain containing, family O member 1
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PQLC2 PQ loop repeat containing 2
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTK6 protein tyrosine kinase 6
QPCTL glutaminyl-peptide cyclotransferase-like
REM1 RAS (RAD and GEM)-like GTP-binding 1
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SCG2 secretogranin II
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SORBS3 sorbin and SH3 domain containing 3
STAG3 stromal antigen 3
STARD5 StAR-related lipid transfer (START) domain containing 5
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TEP1 telomerase-associated protein 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM159 transmembrane protein 159
TMEM242 transmembrane protein 242
TUBA4B tubulin, alpha 4b
VEZT vezatin, adherens junctions transmembrane protein
VNN1 vanin 1
WDR4 WD repeat domain 4
ZNF205 zinc finger protein 205
ZNF268 zinc finger protein 268
ZNF286A zinc finger protein 286A
ZNF37BP zinc finger protein 37B, pseudogene
ZNF623 zinc finger protein 623
ZNF652 zinc finger protein 652