Prestwick-857-4980 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the Prestwick-857-4980 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
ANG angiogenin, ribonuclease, RNase A family, 5
ANP32A-IT1 ANP32A intronic transcript 1
ARHGAP33 Rho GTPase activating protein 33
ARHGAP4 Rho GTPase activating protein 4
ARNT aryl hydrocarbon receptor nuclear translocator
ARTN artemin
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BIN1 bridging integrator 1
BMP5 bone morphogenetic protein 5
C6ORF10 chromosome 6 open reading frame 10
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCL27 chemokine (C-C motif) ligand 27
CD5 CD5 molecule
CD52 CD52 molecule
CEP41 centrosomal protein 41kDa
CFHR4 complement factor H-related 4
CHN2 chimerin 2
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLCN7 chloride channel, voltage-sensitive 7
CLTC clathrin, heavy chain (Hc)
CSF1R colony stimulating factor 1 receptor
CSNK1G1 casein kinase 1, gamma 1
CTSS cathepsin S
DOK2 docking protein 2, 56kDa
EFR3B EFR3 homolog B (S. cerevisiae)
ENO3 enolase 3 (beta, muscle)
EPHA1 EPH receptor A1
FADS3 fatty acid desaturase 3
FAM134B family with sequence similarity 134, member B
FBXO2 F-box protein 2
FGF16 fibroblast growth factor 16
FSCN1 fascin actin-bundling protein 1
GJB3 gap junction protein, beta 3, 31kDa
GLP1R glucagon-like peptide 1 receptor
HIST1H3B histone cluster 1, H3b
HOMER3 homer scaffolding protein 3
HYAL3 hyaluronoglucosaminidase 3
ICA1 islet cell autoantigen 1, 69kDa
ICAM1 intercellular adhesion molecule 1
IDS iduronate 2-sulfatase
IGHM immunoglobulin heavy constant mu
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT19P2 keratin 19 pseudogene 2
LEPR leptin receptor
LIME1 Lck interacting transmembrane adaptor 1
MAP2 microtubule-associated protein 2
MAPK7 mitogen-activated protein kinase 7
MBD2 methyl-CpG binding domain protein 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP13 matrix metallopeptidase 13
MTCP1 mature T-cell proliferation 1
NADK NAD kinase
NELL2 NEL-like 2 (chicken)
NF2 neurofibromin 2 (merlin)
NME5 NME/NM23 family member 5
NNAT neuronatin
NR2F1 nuclear receptor subfamily 2, group F, member 1
NYX nyctalopin
OBSL1 obscurin-like 1
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PCDHB13 protocadherin beta 13
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM7 PDZ and LIM domain 7 (enigma)
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLAU plasminogen activator, urokinase
PRB1 proline-rich protein BstNI subfamily 1
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RBM5 RNA binding motif protein 5
RPL10L ribosomal protein L10-like
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SELPLG selectin P ligand
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SERGEF secretion regulating guanine nucleotide exchange factor
SIDT2 SID1 transmembrane family, member 2
SLC22A14 solute carrier family 22, member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SORBS2 sorbin and SH3 domain containing 2
SOX18 SRY (sex determining region Y)-box 18
SSX1 synovial sarcoma, X breakpoint 1
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D22A TBC1 domain family, member 22A
TLR5 toll-like receptor 5
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TRIM3 tripartite motif containing 3
TRIO trio Rho guanine nucleotide exchange factor
TUBA4B tubulin, alpha 4b
VWA5A von Willebrand factor A domain containing 5A
WDFY3 WD repeat and FYVE domain containing 3
WDTC1 WD and tetratricopeptide repeats 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZBTB22 zinc finger and BTB domain containing 22
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF688 zinc finger protein 688

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADCY7 adenylate cyclase 7
ALOX15 arachidonate 15-lipoxygenase
ASAP1-IT1 ASAP1 intronic transcript 1
BAHCC1 BAH domain and coiled-coil containing 1
C11ORF68 chromosome 11 open reading frame 68
C5AR2 complement component 5a receptor 2
CAPN15 calpain 15
CCDC121 coiled-coil domain containing 121
CD34 CD34 molecule
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHKB choline kinase beta
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CIDEC cell death-inducing DFFA-like effector c
CLDN1 claudin 1
CLGN calmegin
CNGB3 cyclic nucleotide gated channel beta 3
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CSTA cystatin A (stefin A)
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DGKE diacylglycerol kinase, epsilon 64kDa
DYSF dysferlin
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM204A family with sequence similarity 204, member A
FBXL15 F-box and leucine-rich repeat protein 15
FILIP1L filamin A interacting protein 1-like
FRMD1 FERM domain containing 1
GALK1 galactokinase 1
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GRAMD1C GRAM domain containing 1C
GSAP gamma-secretase activating protein
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H2AI histone cluster 1, H2ai
HIST1H2BO histone cluster 1, H2bo
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGSF1 immunoglobulin superfamily, member 1
IPO8 importin 8
ISG15 ISG15 ubiquitin-like modifier
ITGA10 integrin, alpha 10
KIAA0754 KIAA0754
KLF3 Kruppel-like factor 3 (basic)
LOC729164 hCG1732469
LZTS3 leucine zipper, putative tumor suppressor family member 3
MBOAT2 membrane bound O-acyltransferase domain containing 2
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR1H3 nuclear receptor subfamily 1, group H, member 3
NT5DC3 5'-nucleotidase domain containing 3
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PEX26 peroxisomal biogenesis factor 26
PHEX phosphate regulating endopeptidase homolog, X-linked
PLCD1 phospholipase C, delta 1
PLEKHA6 pleckstrin homology domain containing, family A member 6
POLL polymerase (DNA directed), lambda
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PROS1 protein S (alpha)
PTPRS protein tyrosine phosphatase, receptor type, S
QSER1 glutamine and serine rich 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RGS2 regulator of G-protein signaling 2
RLN1 relaxin 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RWDD3 RWD domain containing 3
SCPEP1 serine carboxypeptidase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC12A8 solute carrier family 12, member 8
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SLIT2 slit homolog 2 (Drosophila)
SLMO1 slowmo homolog 1 (Drosophila)
SNX15 sorting nexin 15
STAG3 stromal antigen 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYBU syntabulin (syntaxin-interacting)
SYT17 synaptotagmin XVII
TESC tescalcin
TMEM121 transmembrane protein 121
TMEM212 transmembrane protein 212
TMEM242 transmembrane protein 242
UCN urocortin
VLDLR very low density lipoprotein receptor
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WFDC2 WAP four-disulfide core domain 2
ZBED1 zinc finger, BED-type containing 1
ZNF16 zinc finger protein 16
ZNF33B zinc finger protein 33B
ZNF606 zinc finger protein 606
ZNF747 zinc finger protein 747
ZNF804A zinc finger protein 804A