Prestwick-857-3016 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the Prestwick-857-3016 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8
ADGRB3 adhesion G protein-coupled receptor B3
AGBL3 ATP/GTP binding protein-like 3
AGER advanced glycosylation end product-specific receptor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APC adenomatous polyposis coli
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ATP13A2 ATPase type 13A2
BMP7 bone morphogenetic protein 7
BMP8A bone morphogenetic protein 8a
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C21ORF2 chromosome 21 open reading frame 2
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CENPO centromere protein O
CHMP6 charged multivesicular body protein 6
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CSF1 colony stimulating factor 1 (macrophage)
CXCR3 chemokine (C-X-C motif) receptor 3
EDDM3B epididymal protein 3B
EFNA3 ephrin-A3
EFNB3 ephrin-B3
EGOT eosinophil granule ontogeny transcript (non-protein coding)
EMID1 EMI domain containing 1
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FBLN1 fibulin 1
FBXO22 F-box protein 22
FOXA2 forkhead box A2
GABARAPL3 GABA(A) receptors associated protein like 3, pseudogene
GAN gigaxonin
GLE1 GLE1 RNA export mediator
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPX2 glutathione peroxidase 2
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HOMER3 homer scaffolding protein 3
HOXB3 homeobox B3
INF2 inverted formin, FH2 and WH2 domain containing
KL klotho
KLHL3 kelch-like family member 3
KNG1 kininogen 1
LAMB4 laminin, beta 4
LAMP1 lysosomal-associated membrane protein 1
LOX lysyl oxidase
MBNL1 muscleblind-like splicing regulator 1
MLXIP MLX interacting protein
MMP19 matrix metallopeptidase 19
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MUC1 mucin 1, cell surface associated
NCR1 natural cytotoxicity triggering receptor 1
NFASC neurofascin
NMT1 N-myristoyltransferase 1
NOL10 nucleolar protein 10
NOX1 NADPH oxidase 1
NR5A2 nuclear receptor subfamily 5, group A, member 2
OGFR opioid growth factor receptor
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PAX5 paired box 5
PDE10A phosphodiesterase 10A
PDLIM7 PDZ and LIM domain 7 (enigma)
PLXNB3 plexin B3
PMEPA1 prostate transmembrane protein, androgen induced 1
PML promyelocytic leukemia
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PTGES prostaglandin E synthase
PTH1R parathyroid hormone 1 receptor
PTHLH parathyroid hormone-like hormone
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PYCRL pyrroline-5-carboxylate reductase-like
RAB11B RAB11B, member RAS oncogene family
RAB26 RAB26, member RAS oncogene family
RASAL2 RAS protein activator like 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RBP4 retinol binding protein 4, plasma
REEP2 receptor accessory protein 2
RETN resistin
RNGTT RNA guanylyltransferase and 5'-phosphatase
RPH3AL rabphilin 3A-like (without C2 domains)
SENP6 SUMO1/sentrin specific peptidase 6
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SOCS3 suppressor of cytokine signaling 3
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
TACR1 tachykinin receptor 1
TECPR2 tectonin beta-propeller repeat containing 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGM4 transglutaminase 4
THPO thrombopoietin
TMEM242 transmembrane protein 242
TMOD1 tropomodulin 1
TNPO2 transportin 2
TRIP6 thyroid hormone receptor interactor 6
VCX2 variable charge, X-linked 2
ZNF10 zinc finger protein 10

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADGRD2 adhesion G protein-coupled receptor D2
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
APOC4 apolipoprotein C-IV
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BTF3P11 basic transcription factor 3 pseudogene 11
C3ORF14 chromosome 3 open reading frame 14
C8A complement component 8, alpha polypeptide
CCDC33 coiled-coil domain containing 33
CD37 CD37 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD79B CD79b molecule, immunoglobulin-associated beta
CDK20 cyclin-dependent kinase 20
CDKL3 cyclin-dependent kinase-like 3
CDR2L cerebellar degeneration-related protein 2-like
CFAP45 cilia and flagella associated protein 45
CLCF1 cardiotrophin-like cytokine factor 1
CLCN5 chloride channel, voltage-sensitive 5
CNN1 calponin 1, basic, smooth muscle
CNPY4 canopy FGF signaling regulator 4
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DTX4 deltex 4, E3 ubiquitin ligase
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
FAM106A family with sequence similarity 106, member A
FBXL7 F-box and leucine-rich repeat protein 7
FRMPD1 FERM and PDZ domain containing 1
GIF gastric intrinsic factor (vitamin B synthesis)
GJA1 gap junction protein, alpha 1, 43kDa
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPR35 G protein-coupled receptor 35
GRB7 growth factor receptor-bound protein 7
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUCA2A guanylate cyclase activator 2A (guanylin)
HIST1H3G histone cluster 1, H3g
HOXA6 homeobox A6
HOXC10 homeobox C10
HOXC8 homeobox C8
HOXD10 homeobox D10
HRAS Harvey rat sarcoma viral oncogene homolog
IBSP integrin-binding sialoprotein
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
JAM3 junctional adhesion molecule 3
JPH3 junctophilin 3
KCNK12 potassium channel, two pore domain subfamily K, member 12
KPTN kaptin (actin binding protein)
LIME1 Lck interacting transmembrane adaptor 1
LOC57399 uncharacterized gastric protein ZA52P
LRP5L low density lipoprotein receptor-related protein 5-like
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MRPS18C mitochondrial ribosomal protein S18C
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NINJ2 ninjurin 2
NLGN1 neuroligin 1
NME8 NME/NM23 family member 8
NMUR1 neuromedin U receptor 1
NNAT neuronatin
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PADI2 peptidyl arginine deiminase, type II
PBOV1 prostate and breast cancer overexpressed 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE7B phosphodiesterase 7B
PLA2G3 phospholipase A2, group III
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PROX1 prospero homeobox 1
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RBM12B-AS1 RBM12B antisense RNA 1
RPGRIP1L RPGRIP1-like
SKI SKI proto-oncogene
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SMR3B submaxillary gland androgen regulated protein 3B
SP1 Sp1 transcription factor
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STATH statherin
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TCHH trichohyalin
TFDP3 transcription factor Dp family, member 3
TIMP2 TIMP metallopeptidase inhibitor 2
TMC5 transmembrane channel-like 5
TMEM212 transmembrane protein 212
TOM1 target of myb1 (chicken)
TPSB2 tryptase beta 2 (gene/pseudogene)
UBL4A ubiquitin-like 4A
VASP vasodilator-stimulated phosphoprotein
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF484 zinc finger protein 484
ZNF696 zinc finger protein 696
ZNF749 zinc finger protein 749
ZNF81 zinc finger protein 81