Prestwick-692-4599 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the Prestwick-692-4599 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY9 adenylate cyclase 9
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
APC adenomatous polyposis coli
APLP2 amyloid beta (A4) precursor-like protein 2
APOM apolipoprotein M
ATP10A ATPase, class V, type 10A
ATP13A3 ATPase type 13A3
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
C10ORF10 chromosome 10 open reading frame 10
C5 complement component 5
C9ORF156 chromosome 9 open reading frame 156
CA5B carbonic anhydrase VB, mitochondrial
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCP110 centriolar coiled coil protein 110kDa
CD82 CD82 molecule
CLCN4 chloride channel, voltage-sensitive 4
CLTB clathrin, light chain B
COL14A1 collagen, type XIV, alpha 1
CORO2B coronin, actin binding protein, 2B
CREM cAMP responsive element modulator
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CTNS cystinosin, lysosomal cystine transporter
DBT dihydrolipoamide branched chain transacylase E2
DOCK6 dedicator of cytokinesis 6
EPS8L1 EPS8-like 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM134B family with sequence similarity 134, member B
FBXO11 F-box protein 11
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAB1 GRB2-associated binding protein 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GTF2I general transcription factor IIi
HEMK1 HemK methyltransferase family member 1
ING4 inhibitor of growth family, member 4
INPP5J inositol polyphosphate-5-phosphatase J
IQCK IQ motif containing K
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGB8 integrin, beta 8
JAK2 Janus kinase 2
KIAA1109 KIAA1109
KRT15 keratin 15, type I
LAMC2 laminin, gamma 2
LIG4 ligase IV, DNA, ATP-dependent
LMAN1 lectin, mannose-binding, 1
LRRN2 leucine rich repeat neuronal 2
MBTPS2 membrane-bound transcription factor peptidase, site 2
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MSL3 male-specific lethal 3 homolog (Drosophila)
MTA2 metastasis associated 1 family, member 2
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NUP160 nucleoporin 160kDa
OGDHL oxoglutarate dehydrogenase-like
OLFML2B olfactomedin-like 2B
PALM paralemmin
PAOX polyamine oxidase (exo-N4-amino)
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCDH11Y protocadherin 11 Y-linked
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEX3 peroxisomal biogenesis factor 3
PHF14 PHD finger protein 14
PHF20 PHD finger protein 20
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POFUT1 protein O-fucosyltransferase 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RHEB Ras homolog enriched in brain
RIOK3 RIO kinase 3
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNGTT RNA guanylyltransferase and 5'-phosphatase
RRAGB Ras-related GTP binding B
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SOGA1 suppressor of glucose, autophagy associated 1
SPAG16 sperm associated antigen 16
STK3 serine/threonine kinase 3
TADA2A transcriptional adaptor 2A
TCF4 transcription factor 4
TRIM14 tripartite motif containing 14
TROVE2 TROVE domain family, member 2
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
UBR2 ubiquitin protein ligase E3 component n-recognin 2
VAMP4 vesicle-associated membrane protein 4
WDR76 WD repeat domain 76
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZBED4 zinc finger, BED-type containing 4
ZCCHC4 zinc finger, CCHC domain containing 4
ZFP36L1 ZFP36 ring finger protein-like 1
ZFX zinc finger protein, X-linked
ZNF141 zinc finger protein 141
ZNF225 zinc finger protein 225

decreased expression

Symbol Name
ACE angiotensin I converting enzyme
ACSL5 acyl-CoA synthetase long-chain family member 5
ADRBK2 adrenergic, beta, receptor kinase 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA2P1 annexin A2 pseudogene 1
ARMC6 armadillo repeat containing 6
BFSP1 beaded filament structural protein 1, filensin
BNC1 basonuclin 1
C22ORF46 chromosome 22 open reading frame 46
CA9 carbonic anhydrase IX
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CINP cyclin-dependent kinase 2 interacting protein
CLDN17 claudin 17
CLSTN3 calsyntenin 3
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DUSP9 dual specificity phosphatase 9
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ELSPBP1 epididymal sperm binding protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM184A family with sequence similarity 184, member A
FBXL7 F-box and leucine-rich repeat protein 7
FZD10 frizzled class receptor 10
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GMPR guanosine monophosphate reductase
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GRTP1 growth hormone regulated TBC protein 1
GSTA3 glutathione S-transferase alpha 3
HAMP hepcidin antimicrobial peptide
HIST1H1T histone cluster 1, H1t
HIST1H2AJ histone cluster 1, H2aj
HIST1H4D histone cluster 1, H4d
HPS6 Hermansky-Pudlak syndrome 6
HSPB6 heat shock protein, alpha-crystallin-related, B6
IL2 interleukin 2
IRAK4 interleukin-1 receptor-associated kinase 4
ITPKA inositol-trisphosphate 3-kinase A
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KIAA0319L KIAA0319-like
KRT86 keratin 86, type II
LIMD2 LIM domain containing 2
LIPG lipase, endothelial
LOC100287590 uncharacterized LOC100287590
LOC257152 uncharacterized LOC257152
MAP2 microtubule-associated protein 2
MED9 mediator complex subunit 9
MRPL52 mitochondrial ribosomal protein L52
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NPFFR1 neuropeptide FF receptor 1
NPY6R neuropeptide Y receptor Y6 (pseudogene)
OR1G1 olfactory receptor, family 1, subfamily G, member 1
PADI1 peptidyl arginine deiminase, type I
PARP6 poly (ADP-ribose) polymerase family, member 6
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PLA2G15 phospholipase A2, group XV
PLA2G1B phospholipase A2, group IB (pancreas)
POLH polymerase (DNA directed), eta
PRB3 proline-rich protein BstNI subfamily 3
PROX1 prospero homeobox 1
RFPL3 ret finger protein-like 3
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF126P1 ring finger protein 126 pseudogene 1
ROM1 retinal outer segment membrane protein 1
RPL23AP32 ribosomal protein L23a pseudogene 32
SAMD9 sterile alpha motif domain containing 9
SAYSD1 SAYSVFN motif domain containing 1
SCG2 secretogranin II
SCGB2A2 secretoglobin, family 2A, member 2
SH3D21 SH3 domain containing 21
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLMO1 slowmo homolog 1 (Drosophila)
SMR3A submaxillary gland androgen regulated protein 3A
SP1 Sp1 transcription factor
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TIGD6 tigger transposable element derived 6
TMEM53 transmembrane protein 53
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TOM1 target of myb1 (chicken)
TRAF2 TNF receptor-associated factor 2
TUBA4B tubulin, alpha 4b
UNC93B1 unc-93 homolog B1 (C. elegans)
VGF VGF nerve growth factor inducible
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZFHX2 zinc finger homeobox 2
ZFHX3 zinc finger homeobox 3
ZIC3 Zic family member 3
ZNF205 zinc finger protein 205
ZNF253 zinc finger protein 253
ZNF37BP zinc finger protein 37B, pseudogene
ZNF428 zinc finger protein 428
ZNF749 zinc finger protein 749
ZNF768 zinc finger protein 768