Prestwick-691-4092 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the Prestwick-691-4092 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACOX3 acyl-CoA oxidase 3, pristanoyl
ADGRB2 adhesion G protein-coupled receptor B2
AIM1L absent in melanoma 1-like
APOC4 apolipoprotein C-IV
APP amyloid beta (A4) precursor protein
ARHGAP26 Rho GTPase activating protein 26
ARSD arylsulfatase D
ATG2A autophagy related 2A
BMP7 bone morphogenetic protein 7
CA12 carbonic anhydrase XII
CD22 CD22 molecule
CD58 CD58 molecule
CDK13 cyclin-dependent kinase 13
CEMP1 cementum protein 1
CEP295 centrosomal protein 295kDa
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
COMMD4 COMM domain containing 4
CORO7 coronin 7
CTSZ cathepsin Z
DAAM2 dishevelled associated activator of morphogenesis 2
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DCTN2 dynactin 2 (p50)
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
EIF3F eukaryotic translation initiation factor 3, subunit F
EMC3 ER membrane protein complex subunit 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPS8L1 EPS8-like 1
ERC1 ELKS/RAB6-interacting/CAST family member 1
ERCC4 excision repair cross-complementation group 4
FABP7 fatty acid binding protein 7, brain
FAM163A family with sequence similarity 163, member A
FGF18 fibroblast growth factor 18
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GAS2L1 growth arrest-specific 2 like 1
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
HFE hemochromatosis
HLA-DOA major histocompatibility complex, class II, DO alpha
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
IDI2-AS1 IDI2 antisense RNA 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IL1RN interleukin 1 receptor antagonist
INO80B INO80 complex subunit B
KHK ketohexokinase (fructokinase)
KISS1 KiSS-1 metastasis-suppressor
KLHL18 kelch-like family member 18
KRT4 keratin 4, type II
LINC00312 long intergenic non-protein coding RNA 312
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAN1A2 mannosidase, alpha, class 1A, member 2
MAPK11 mitogen-activated protein kinase 11
MBD2 methyl-CpG binding domain protein 2
MEGF6 multiple EGF-like-domains 6
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
N4BP2L1 NEDD4 binding protein 2-like 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR4A3 nuclear receptor subfamily 4, group A, member 3
ONECUT2 one cut homeobox 2
PAPPA2 pappalysin 2
PBX1 pre-B-cell leukemia homeobox 1
PDE10A phosphodiesterase 10A
PLCD1 phospholipase C, delta 1
PLK4 polo-like kinase 4
PMS2P4 postmeiotic segregation increased 2 pseudogene 4
POM121L2 POM121 transmembrane nucleoporin-like 2
PROL1 proline rich, lacrimal 1
PRSS8 protease, serine, 8
PTCH1 patched 1
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RBM26 RNA binding motif protein 26
RIF1 replication timing regulatory factor 1
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RPH3A rabphilin 3A
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPANXC SPANX family, member C
SPRED2 sprouty-related, EVH1 domain containing 2
SRCAP Snf2-related CREBBP activator protein
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TNIK TRAF2 and NCK interacting kinase
TNS1 tensin 1
TRIO trio Rho guanine nucleotide exchange factor
TSPAN8 tetraspanin 8
VWA5A von Willebrand factor A domain containing 5A
WT1-AS WT1 antisense RNA
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZNF334 zinc finger protein 334
ZNF440 zinc finger protein 440
ZNF613 zinc finger protein 613

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AKAP5 A kinase (PRKA) anchor protein 5
AMH anti-Mullerian hormone
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
BAGE B melanoma antigen
BRSK2 BR serine/threonine kinase 2
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CASS4 Cas scaffolding protein family member 4
CCDC186 coiled-coil domain containing 186
CCDC85C coiled-coil domain containing 85C
CCDC94 coiled-coil domain containing 94
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CISH cytokine inducible SH2-containing protein
CNGB3 cyclic nucleotide gated channel beta 3
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPNE7 copine VII
CTSF cathepsin F
ENO3 enolase 3 (beta, muscle)
ERN2 endoplasmic reticulum to nucleus signaling 2
ERO1LB ERO1-like beta (S. cerevisiae)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EYA4 EYA transcriptional coactivator and phosphatase 4
FKBP5 FK506 binding protein 5
FRS3 fibroblast growth factor receptor substrate 3
GNA14 guanine nucleotide binding protein (G protein), alpha 14
HHAT hedgehog acyltransferase
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIST1H3C histone cluster 1, H3c
HIST1H3I histone cluster 1, H3i
HIST1H4E histone cluster 1, H4e
HMOX1 heme oxygenase 1
HRH2 histamine receptor H2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL18R1 interleukin 18 receptor 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KLHL25 kelch-like family member 25
KRT31 keratin 31, type I
LATS1 large tumor suppressor kinase 1
LIFR leukemia inhibitory factor receptor alpha
LIME1 Lck interacting transmembrane adaptor 1
LINC00115 long intergenic non-protein coding RNA 115
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC390998 ribosomal protein L10 pseudogene
LOXL3 lysyl oxidase-like 3
LPPR1 lipid phosphate phosphatase-related protein type 1
LRRC2 leucine rich repeat containing 2
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAP3K7CL MAP3K7 C-terminal like
MATN3 matrilin 3
MRPL41 mitochondrial ribosomal protein L41
MYO15A myosin XVA
MYO1F myosin IF
MYOZ3 myozenin 3
NARFL nuclear prelamin A recognition factor-like
NGF nerve growth factor (beta polypeptide)
NNAT neuronatin
NPPB natriuretic peptide B
ODF2 outer dense fiber of sperm tails 2
OSBP2 oxysterol binding protein 2
OXCT2 3-oxoacid CoA transferase 2
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PARP8 poly (ADP-ribose) polymerase family, member 8
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PODXL2 podocalyxin-like 2
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PTPN7 protein tyrosine phosphatase, non-receptor type 7
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RUSC2 RUN and SH3 domain containing 2
SCGB2A1 secretoglobin, family 2A, member 1
SCN1B sodium channel, voltage gated, type I beta subunit
SIX3 SIX homeobox 3
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
STRN striatin, calmodulin binding protein
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
TBC1D22B TBC1 domain family, member 22B
TFDP3 transcription factor Dp family, member 3
TGFBI transforming growth factor, beta-induced, 68kDa
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TUBA3C tubulin, alpha 3c
UNC93B1 unc-93 homolog B1 (C. elegans)
USB1 U6 snRNA biogenesis 1
VN1R1 vomeronasal 1 receptor 1
WDR62 WD repeat domain 62
ZBTB6 zinc finger and BTB domain containing 6
ZNF549 zinc finger protein 549
ZNF695 zinc finger protein 695
ZXDB zinc finger, X-linked, duplicated B