Prestwick-691-2813 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the Prestwick-691-2813 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ADORA1 adenosine A1 receptor
AGGF1 angiogenic factor with G patch and FHA domains 1
AKAP17A A kinase (PRKA) anchor protein 17A
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
APLP1 amyloid beta (A4) precursor-like protein 1
AQP3 aquaporin 3 (Gill blood group)
ARHGAP4 Rho GTPase activating protein 4
ARNT aryl hydrocarbon receptor nuclear translocator
ASIC3 acid sensing (proton gated) ion channel 3
BTD biotinidase
CACTIN cactin, spliceosome C complex subunit
CCDC134 coiled-coil domain containing 134
CCDC68 coiled-coil domain containing 68
CDC14A cell division cycle 14A
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
COL19A1 collagen, type XIX, alpha 1
DSTYK dual serine/threonine and tyrosine protein kinase
EGFL7 EGF-like-domain, multiple 7
ERN2 endoplasmic reticulum to nucleus signaling 2
ETV6 ets variant 6
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FLOT1 flotillin 1
GLS glutaminase
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPR1 G protein-coupled receptor 1
GSN gelsolin
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIAA0754 KIAA0754
KIAA1109 KIAA1109
LENEP lens epithelial protein
LMAN1 lectin, mannose-binding, 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAL mal, T-cell differentiation protein
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MBNL1 muscleblind-like splicing regulator 1
MBNL2 muscleblind-like splicing regulator 2
METTL16 methyltransferase like 16
MFSD6 major facilitator superfamily domain containing 6
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MKL1 megakaryoblastic leukemia (translocation) 1
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MSMB microseminoprotein, beta-
MTRF1L mitochondrial translational release factor 1-like
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NF1 neurofibromin 1
NPFF neuropeptide FF-amide peptide precursor
NPIPB3 nuclear pore complex interacting protein family, member B3
ONECUT2 one cut homeobox 2
PCDHGA10 protocadherin gamma subfamily A, 10
PER2 period circadian clock 2
PHF14 PHD finger protein 14
PKN2 protein kinase N2
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRKCI protein kinase C, iota
PVR poliovirus receptor
RB1 retinoblastoma 1
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
REM1 RAS (RAD and GEM)-like GTP-binding 1
RNF19B ring finger protein 19B
RPL35A ribosomal protein L35a
RXRB retinoid X receptor, beta
SECISBP2 SECIS binding protein 2
SH3BP2 SH3-domain binding protein 2
SH3GL3 SH3-domain GRB2-like 3
SIRT5 sirtuin 5
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A4 solute carrier family 16, member 4
SLC17A2 solute carrier family 17, member 2
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNRK SNF related kinase
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
SYNC syncoilin, intermediate filament protein
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAOK2 TAO kinase 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMC6 transmembrane channel-like 6
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTC9 tetratricopeptide repeat domain 9
TUBA3D tubulin, alpha 3d
ZC3H3 zinc finger CCCH-type containing 3
ZNF235 zinc finger protein 235
ZNF236 zinc finger protein 236
ZNF41 zinc finger protein 41
ZNF771 zinc finger protein 771
ZYX zyxin

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ATP10D ATPase, class V, type 10D
BMP15 bone morphogenetic protein 15
C11ORF21 chromosome 11 open reading frame 21
C1QB complement component 1, q subcomponent, B chain
C8ORF60 chromosome 8 open reading frame 60
CDH10 cadherin 10, type 2 (T2-cadherin)
CDO1 cysteine dioxygenase type 1
CEP41 centrosomal protein 41kDa
CFAP45 cilia and flagella associated protein 45
CHMP6 charged multivesicular body protein 6
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CIC capicua transcriptional repressor
CNTN1 contactin 1
COPZ2 coatomer protein complex, subunit zeta 2
CRLF1 cytokine receptor-like factor 1
CSF1R colony stimulating factor 1 receptor
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DMRT1 doublesex and mab-3 related transcription factor 1
ELSPBP1 epididymal sperm binding protein 1
EXOSC1 exosome component 1
FADS2 fatty acid desaturase 2
FBXL6 F-box and leucine-rich repeat protein 6
FBXW12 F-box and WD repeat domain containing 12
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGD1 FYVE, RhoGEF and PH domain containing 1
FKBP10 FK506 binding protein 10, 65 kDa
FOXI1 forkhead box I1
GLS2 glutaminase 2 (liver, mitochondrial)
GSTTP1 glutathione S-transferase theta pseudogene 1
HIST1H2AK histone cluster 1, H2ak
HIST1H3B histone cluster 1, H3b
HIST1H3E histone cluster 1, H3e
HOXA4 homeobox A4
HOXC8 homeobox C8
INHBE inhibin, beta E
IRS4 insulin receptor substrate 4
KDM8 lysine (K)-specific demethylase 8
KLF2 Kruppel-like factor 2
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAGEA6 melanoma antigen family A6
MAPK8 mitogen-activated protein kinase 8
MGC12488
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MRPL41 mitochondrial ribosomal protein L41
MUC3A mucin 3A, cell surface associated
NCALD neurocalcin delta
NCF2 neutrophil cytosolic factor 2
NDE1 nudE neurodevelopment protein 1
NRSN2 neurensin 2
ONECUT1 one cut homeobox 1
PC pyruvate carboxylase
PICK1 protein interacting with PRKCA 1
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLEKHA6 pleckstrin homology domain containing, family A member 6
POLL polymerase (DNA directed), lambda
POMT2 protein-O-mannosyltransferase 2
PRICKLE3 prickle homolog 3 (Drosophila)
PRPH peripherin
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PSD4 pleckstrin and Sec7 domain containing 4
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RGS19 regulator of G-protein signaling 19
RPL32 ribosomal protein L32
RPS15A ribosomal protein S15a
SERGEF secretion regulating guanine nucleotide exchange factor
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMA4 glucuronidase, beta pseudogene
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOX12 SRY (sex determining region Y)-box 12
SPON2 spondin 2, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STRA6 stimulated by retinoic acid 6
TBC1D2 TBC1 domain family, member 2
TBC1D22B TBC1 domain family, member 22B
TBL1Y transducin (beta)-like 1, Y-linked
TCP10 t-complex 10
TGFBR3 transforming growth factor, beta receptor III
THRB thyroid hormone receptor, beta
TMEM177 transmembrane protein 177
TNS2 tensin 2
TOR4A torsin family 4, member A
TSGA10 testis specific, 10
TSNAXIP1 translin-associated factor X interacting protein 1
UPP1 uridine phosphorylase 1
WDR62 WD repeat domain 62
WNT16 wingless-type MMTV integration site family, member 16
ZMYM3 zinc finger, MYM-type 3
ZNF205 zinc finger protein 205
ZNF665 zinc finger protein 665
ZNF747 zinc finger protein 747
ZNF750 zinc finger protein 750