Prestwick-689-7173 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the Prestwick-689-7173 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRA2 adhesion G protein-coupled receptor A2
AKAP5 A kinase (PRKA) anchor protein 5
AKR1C2 aldo-keto reductase family 1, member C2
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
APOM apolipoprotein M
AQP3 aquaporin 3 (Gill blood group)
ARC activity-regulated cytoskeleton-associated protein
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BIRC3 baculoviral IAP repeat containing 3
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCNO cyclin O
CD79B CD79b molecule, immunoglobulin-associated beta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DBT dihydrolipoamide branched chain transacylase E2
DICER1 dicer 1, ribonuclease type III
DNAI2 dynein, axonemal, intermediate chain 2
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ESR1 estrogen receptor 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GBP2 guanylate binding protein 2, interferon-inducible
GJB3 gap junction protein, beta 3, 31kDa
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HP1BP3 heterochromatin protein 1, binding protein 3
IFNA14 interferon, alpha 14
IFT140 intraflagellar transport 140
IRF6 interferon regulatory factor 6
KRIT1 KRIT1, ankyrin repeat containing
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LOXL3 lysyl oxidase-like 3
MAGOH2P mago-nashi homolog 2, pseudogene
MAX MYC associated factor X
MED20 mediator complex subunit 20
MIIP migration and invasion inhibitory protein
MVD mevalonate (diphospho) decarboxylase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRF1 nuclear respiratory factor 1
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PACS1 phosphofurin acidic cluster sorting protein 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCM1 pericentriolar material 1
PDCD2 programmed cell death 2
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDE8B phosphodiesterase 8B
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PPP5C protein phosphatase 5, catalytic subunit
PRKCH protein kinase C, eta
PRPF18 pre-mRNA processing factor 18
PSD3 pleckstrin and Sec7 domain containing 3
PSPH phosphoserine phosphatase
PTAFR platelet-activating factor receptor
PTBP3 polypyrimidine tract binding protein 3
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
QKI QKI, KH domain containing, RNA binding
RAD51B RAD51 paralog B
RARG retinoic acid receptor, gamma
RASA3 RAS p21 protein activator 3
RBM3 RNA binding motif (RNP1, RRM) protein 3
RNF121 ring finger protein 121
RNF6 ring finger protein (C3H2C3 type) 6
RPL13 ribosomal protein L13
S100A9 S100 calcium binding protein A9
SAFB2 scaffold attachment factor B2
SECTM1 secreted and transmembrane 1
SIK2 salt-inducible kinase 2
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SP100 SP100 nuclear antigen
SRI sorcin
STBD1 starch binding domain 1
SUGP1 SURP and G patch domain containing 1
TACR3 tachykinin receptor 3
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TEX40 testis expressed 40
THBD thrombomodulin
TMEM70 transmembrane protein 70
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNK2 tyrosine kinase, non-receptor, 2
TRAF3 TNF receptor-associated factor 3
TTLL1 tubulin tyrosine ligase-like family member 1
VARS valyl-tRNA synthetase
WAS Wiskott-Aldrich syndrome
WLS wntless Wnt ligand secretion mediator
ZNF365 zinc finger protein 365
ZNF473 zinc finger protein 473

decreased expression

Symbol Name
AHDC1 AT hook, DNA binding motif, containing 1
AMPD2 adenosine monophosphate deaminase 2
ANKRD40 ankyrin repeat domain 40
ANO10 anoctamin 10
ATAD5 ATPase family, AAA domain containing 5
ATP7B ATPase, Cu++ transporting, beta polypeptide
BBS10 Bardet-Biedl syndrome 10
BCL7B B-cell CLL/lymphoma 7B
BTBD2 BTB (POZ) domain containing 2
C22ORF29 chromosome 22 open reading frame 29
C7ORF43 chromosome 7 open reading frame 43
CARD8 caspase recruitment domain family, member 8
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CGREF1 cell growth regulator with EF-hand domain 1
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CIR1 corepressor interacting with RBPJ, 1
CORO1A coronin, actin binding protein, 1A
CUEDC1 CUE domain containing 1
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
DNA2 DNA replication helicase/nuclease 2
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DUSP8 dual specificity phosphatase 8
EIF5A2 eukaryotic translation initiation factor 5A2
ELMO3 engulfment and cell motility 3
EVPL envoplakin
FAM188A family with sequence similarity 188, member A
FKBP5 FK506 binding protein 5
FOXA1 forkhead box A1
GRAMD4 GRAM domain containing 4
GTPBP6 GTP binding protein 6 (putative)
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BO histone cluster 1, H2bo
HPS6 Hermansky-Pudlak syndrome 6
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
INPPL1 inositol polyphosphate phosphatase-like 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRF9 interferon regulatory factor 9
KAT2A K(lysine) acetyltransferase 2A
LOXL1 lysyl oxidase-like 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAST3 microtubule associated serine/threonine kinase 3
MCMBP minichromosome maintenance complex binding protein
MED15 mediator complex subunit 15
MPI mannose phosphate isomerase
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MXD3 MAX dimerization protein 3
NBEAL2 neurobeachin-like 2
NES nestin
NOTCH1 notch 1
NUP62CL nucleoporin 62kDa C-terminal like
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PC pyruvate carboxylase
PCSK7 proprotein convertase subtilisin/kexin type 7
PLD2 phospholipase D2
PLEKHO1 pleckstrin homology domain containing, family O member 1
PNPLA6 patatin-like phospholipase domain containing 6
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTPRG protein tyrosine phosphatase, receptor type, G
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RECQL4 RecQ protein-like 4
REPS2 RALBP1 associated Eps domain containing 2
RIBC2 RIB43A domain with coiled-coils 2
RNF25 ring finger protein 25
SCD5 stearoyl-CoA desaturase 5
SETD8 SET domain containing (lysine methyltransferase) 8
SLC12A8 solute carrier family 12, member 8
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC41A3 solute carrier family 41, member 3
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNX15 sorting nexin 15
SSFA2 sperm specific antigen 2
STAG3 stromal antigen 3
STRN4 striatin, calmodulin binding protein 4
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
SUSD4 sushi domain containing 4
TBX19 T-box 19
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TLN1 talin 1
TMSB15B thymosin beta 15B
TMUB2 transmembrane and ubiquitin-like domain containing 2
TRAPPC11 trafficking protein particle complex 11
TRAPPC2 trafficking protein particle complex 2
TRIM25 tripartite motif containing 25
TRIM52 tripartite motif containing 52
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
USP6NL USP6 N-terminal like
VASH2 vasohibin 2
VGF VGF nerve growth factor inducible
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VWA1 von Willebrand factor A domain containing 1
YEATS4 YEATS domain containing 4
ZFP36 ZFP36 ring finger protein
ZNF268 zinc finger protein 268
ZNF408 zinc finger protein 408
ZNF701 zinc finger protein 701