Prestwick-685-6043 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the Prestwick-685-6043 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACSL4 acyl-CoA synthetase long-chain family member 4
ADAM23 ADAM metallopeptidase domain 23
AGFG2 ArfGAP with FG repeats 2
AKAP13 A kinase (PRKA) anchor protein 13
ARHGAP4 Rho GTPase activating protein 4
C4BPB complement component 4 binding protein, beta
CAMK4 calcium/calmodulin-dependent protein kinase IV
CDHR2 cadherin-related family member 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFAP70 cilia and flagella associated protein 70
CHN2 chimerin 2
CLCN7 chloride channel, voltage-sensitive 7
CRYGD crystallin, gamma D
CXXC4 CXXC finger protein 4
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DNAI2 dynein, axonemal, intermediate chain 2
ERO1LB ERO1-like beta (S. cerevisiae)
FABP4 fatty acid binding protein 4, adipocyte
FAM182B family with sequence similarity 182, member B
FAM46C family with sequence similarity 46, member C
FBXO46 F-box protein 46
FGF1 fibroblast growth factor 1 (acidic)
FN1 fibronectin 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GSTTP1 glutathione S-transferase theta pseudogene 1
HGFAC HGF activator
HLF hepatic leukemia factor
HNF4A hepatocyte nuclear factor 4, alpha
HPSE2 heparanase 2 (inactive)
HR hair growth associated
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IFNA17 interferon, alpha 17
IFT27 intraflagellar transport 27
IL9R interleukin 9 receptor
IVL involucrin
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LAMB4 laminin, beta 4
LAMP1 lysosomal-associated membrane protein 1
LPCAT4 lysophosphatidylcholine acyltransferase 4
LTBP4 latent transforming growth factor beta binding protein 4
MLANA melan-A
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MYH15 myosin, heavy chain 15
MYL10 myosin, light chain 10, regulatory
NDRG2 NDRG family member 2
NPR1 natriuretic peptide receptor 1
NR2E3 nuclear receptor subfamily 2, group E, member 3
NUDC nudC nuclear distribution protein
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PARP8 poly (ADP-ribose) polymerase family, member 8
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDHB13 protocadherin beta 13
PCSK6 proprotein convertase subtilisin/kexin type 6
PDCD2 programmed cell death 2
PDE10A phosphodiesterase 10A
PMEL premelanosome protein
POLM polymerase (DNA directed), mu
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRKG2 protein kinase, cGMP-dependent, type II
PRR34 proline rich 34
PTPRJ protein tyrosine phosphatase, receptor type, J
PVR poliovirus receptor
RAB3B RAB3B, member RAS oncogene family
RARA retinoic acid receptor, alpha
RASA3 RAS p21 protein activator 3
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RGS4 regulator of G-protein signaling 4
RPH3A rabphilin 3A
RUNDC3A RUN domain containing 3A
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SOCS7 suppressor of cytokine signaling 7
SORBS1 sorbin and SH3 domain containing 1
SVIL supervillin
TAOK2 TAO kinase 2
TAPBP TAP binding protein (tapasin)
TBX2 T-box 2
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMX4 thioredoxin-related transmembrane protein 4
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNXB tenascin XB
TRPM3 transient receptor potential cation channel, subfamily M, member 3
VAV2 vav 2 guanine nucleotide exchange factor
ZBTB22 zinc finger and BTB domain containing 22
ZFPL1 zinc finger protein-like 1
ZNF137P zinc finger protein 137, pseudogene
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ACTL8 actin-like 8
ADCY7 adenylate cyclase 7
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALS2CL ALS2 C-terminal like
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARRB1 arrestin, beta 1
ASAP1-IT1 ASAP1 intronic transcript 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BFSP1 beaded filament structural protein 1, filensin
C1ORF109 chromosome 1 open reading frame 109
C7ORF43 chromosome 7 open reading frame 43
C8ORF44 chromosome 8 open reading frame 44
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC85C coiled-coil domain containing 85C
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CENPO centromere protein O
CRELD1 cysteine-rich with EGF-like domains 1
CTSF cathepsin F
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DIXDC1 DIX domain containing 1
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DNM3 dynamin 3
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EFNA3 ephrin-A3
ENO2 enolase 2 (gamma, neuronal)
ERCC5 excision repair cross-complementation group 5
FAM169A family with sequence similarity 169, member A
FAM76A family with sequence similarity 76, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXI1 forkhead box I1
FRK fyn-related Src family tyrosine kinase
FRS2 fibroblast growth factor receptor substrate 2
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR21 G protein-coupled receptor 21
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUSBP3 glucuronidase, beta pseudogene 3
HINFP histone H4 transcription factor
HIST1H2AG histone cluster 1, H2ag
HIST1H2AI histone cluster 1, H2ai
HOXB2 homeobox B2
HOXC10 homeobox C10
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KIAA0355 KIAA0355
KIF13B kinesin family member 13B
KLHL26 kelch-like family member 26
KLHL28 kelch-like family member 28
KREMEN2 kringle containing transmembrane protein 2
LMX1B LIM homeobox transcription factor 1, beta
LPXN leupaxin
MAP1S microtubule-associated protein 1S
MCOLN3 mucolipin 3
NOD1 nucleotide-binding oligomerization domain containing 1
NOL10 nucleolar protein 10
NPIPB3 nuclear pore complex interacting protein family, member B3
NUP62CL nucleoporin 62kDa C-terminal like
PCDHA5 protocadherin alpha 5
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PVRL3 poliovirus receptor-related 3
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGS2 regulator of G-protein signaling 2
RHOBTB2 Rho-related BTB domain containing 2
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIN2 Ras and Rab interactor 2
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SPRYD7 SPRY domain containing 7
STRA6 stimulated by retinoic acid 6
TCHH trichohyalin
TDRKH tudor and KH domain containing
TEX40 testis expressed 40
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMEM110 transmembrane protein 110
TMEM53 transmembrane protein 53
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAPPC13 trafficking protein particle complex 13
TRIM21 tripartite motif containing 21
USB1 U6 snRNA biogenesis 1
USP20 ubiquitin specific peptidase 20
USP36 ubiquitin specific peptidase 36
VASH2 vasohibin 2
VGF VGF nerve growth factor inducible
VPS9D1 VPS9 domain containing 1
YY2 YY2 transcription factor
ZBED1 zinc finger, BED-type containing 1
ZDHHC11 zinc finger, DHHC-type containing 11
ZFHX4 zinc finger homeobox 4
ZNF428 zinc finger protein 428
ZNF516 zinc finger protein 516
ZNF573 zinc finger protein 573
ZNF862 zinc finger protein 862