Prestwick-685-4705 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the Prestwick-685-4705 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ADAM12 ADAM metallopeptidase domain 12
ADCY1 adenylate cyclase 1 (brain)
AIM2 absent in melanoma 2
AMPD1 adenosine monophosphate deaminase 1
ANP32A-IT1 ANP32A intronic transcript 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP3B2 adaptor-related protein complex 3, beta 2 subunit
AQP3 aquaporin 3 (Gill blood group)
ATM ATM serine/threonine kinase
BUD31 BUD31 homolog (S. cerevisiae)
CABP2 calcium binding protein 2
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASQ2 calsequestrin 2 (cardiac muscle)
CCDC181 coiled-coil domain containing 181
CCKAR cholecystokinin A receptor
CDC14A cell division cycle 14A
CES1 carboxylesterase 1
CHD5 chromodomain helicase DNA binding protein 5
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLCN6 chloride channel, voltage-sensitive 6
CNOT4 CCR4-NOT transcription complex, subunit 4
COL4A4 collagen, type IV, alpha 4
CTBP2 C-terminal binding protein 2
CYHR1 cysteine/histidine-rich 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLX2 distal-less homeobox 2
DNM3 dynamin 3
DST dystonin
FBN1 fibrillin 1
FOXA2 forkhead box A2
GAP43 growth associated protein 43
GFI1 growth factor independent 1 transcription repressor
GPNMB glycoprotein (transmembrane) nmb
GPSM3 G-protein signaling modulator 3
H2AFX H2A histone family, member X
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPB3 heat shock 27kDa protein 3
HYAL3 hyaluronoglucosaminidase 3
ICAM1 intercellular adhesion molecule 1
ICOSLG inducible T-cell co-stimulator ligand
IFNA14 interferon, alpha 14
IGFBP6 insulin-like growth factor binding protein 6
KANSL1L KAT8 regulatory NSL complex subunit 1-like
LAMP1 lysosomal-associated membrane protein 1
LTB4R leukotriene B4 receptor
MALL mal, T-cell differentiation protein-like
MAP2K7 mitogen-activated protein kinase kinase 7
MID1 midline 1
MTCP1 mature T-cell proliferation 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTSS1L metastasis suppressor 1-like
N4BP2L1 NEDD4 binding protein 2-like 1
NEFM neurofilament, medium polypeptide
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NPR1 natriuretic peptide receptor 1
NPVF neuropeptide VF precursor
OLFM4 olfactomedin 4
OSBPL10 oxysterol binding protein-like 10
PCDHGA8 protocadherin gamma subfamily A, 8
PDLIM7 PDZ and LIM domain 7 (enigma)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PITX1 paired-like homeodomain 1
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RBBP4 retinoblastoma binding protein 4
RPS3A ribosomal protein S3A
SAFB2 scaffold attachment factor B2
SIX1 SIX homeobox 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMG7 SMG7 nonsense mediated mRNA decay factor
SMIM14 small integral membrane protein 14
SOX9 SRY (sex determining region Y)-box 9
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
TAAR5 trace amine associated receptor 5
TACR1 tachykinin receptor 1
TCF3 transcription factor 3
THOC5 THO complex 5
TJAP1 tight junction associated protein 1 (peripheral)
TLL2 tolloid-like 2
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNXB tenascin XB
TPMT thiopurine S-methyltransferase
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VAV2 vav 2 guanine nucleotide exchange factor
VEZT vezatin, adherens junctions transmembrane protein
ZMYND8 zinc finger, MYND-type containing 8
ZNF230 zinc finger protein 230
ZNF362 zinc finger protein 362
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD17B abhydrolase domain containing 17B
AFF4 AF4/FMR2 family, member 4
AGO1 argonaute RISC catalytic component 1
APLP1 amyloid beta (A4) precursor-like protein 1
BCAS1 breast carcinoma amplified sequence 1
C11ORF63 chromosome 11 open reading frame 63
C17ORF80 chromosome 17 open reading frame 80
C1ORF56 chromosome 1 open reading frame 56
C22ORF29 chromosome 22 open reading frame 29
CAMK1 calcium/calmodulin-dependent protein kinase I
CCP110 centriolar coiled coil protein 110kDa
CDHR2 cadherin-related family member 2
CHML choroideremia-like (Rab escort protein 2)
CHRM3 cholinergic receptor, muscarinic 3
CIR1 corepressor interacting with RBPJ, 1
CLCN2 chloride channel, voltage-sensitive 2
CRYGC crystallin, gamma C
CTAGE5 CTAGE family, member 5
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DCAF13 DDB1 and CUL4 associated factor 13
DENND4A DENN/MADD domain containing 4A
EFNA3 ephrin-A3
EIF5A2 eukaryotic translation initiation factor 5A2
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FAM189A2 family with sequence similarity 189, member A2
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FILIP1L filamin A interacting protein 1-like
FRK fyn-related Src family tyrosine kinase
GDAP1 ganglioside induced differentiation associated protein 1
GEMIN8 gem (nuclear organelle) associated protein 8
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPC3 glypican 3
GPR27 G protein-coupled receptor 27
GRTP1 growth hormone regulated TBC protein 1
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IER3IP1 immediate early response 3 interacting protein 1
IFT22 intraflagellar transport 22
IPO8 importin 8
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
IRF1 interferon regulatory factor 1
ITPKB inositol-trisphosphate 3-kinase B
KIF13A kinesin family member 13A
KLF13 Kruppel-like factor 13
KLHL28 kelch-like family member 28
KRT31 keratin 31, type I
LHX6 LIM homeobox 6
LRRC20 leucine rich repeat containing 20
LYRM9 LYR motif containing 9
MBTPS2 membrane-bound transcription factor peptidase, site 2
MRPL44 mitochondrial ribosomal protein L44
MUC3A mucin 3A, cell surface associated
NCS1 neuronal calcium sensor 1
NEUROD1 neuronal differentiation 1
NEUROD4 neuronal differentiation 4
NFE2L3 nuclear factor, erythroid 2-like 3
NLK nemo-like kinase
NSUN3 NOP2/Sun domain family, member 3
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PITX2 paired-like homeodomain 2
PMCH pro-melanin-concentrating hormone
PMEL premelanosome protein
POMT2 protein-O-mannosyltransferase 2
PPT2 palmitoyl-protein thioesterase 2
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PTBP2 polypyrimidine tract binding protein 2
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAB3D RAB3D, member RAS oncogene family
REEP4 receptor accessory protein 4
RPGRIP1L RPGRIP1-like
S100A4 S100 calcium binding protein A4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKI SKI proto-oncogene
SNX15 sorting nexin 15
SNX16 sorting nexin 16
SP1 Sp1 transcription factor
SPINK5 serine peptidase inhibitor, Kazal type 5
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STK16 serine/threonine kinase 16
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBX19 T-box 19
TIGD6 tigger transposable element derived 6
TMEM254 transmembrane protein 254
TMPRSS3 transmembrane protease, serine 3
TRIM25 tripartite motif containing 25
TRIM52 tripartite motif containing 52
TTC23 tetratricopeptide repeat domain 23
TUBB2B tubulin, beta 2B class IIb
UBOX5 U-box domain containing 5
USP27X ubiquitin specific peptidase 27, X-linked
WDR44 WD repeat domain 44
ZNF124 zinc finger protein 124
ZNF468 zinc finger protein 468
ZNF675 zinc finger protein 675
ZNF747 zinc finger protein 747