Prestwick-685-3683 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the Prestwick-685-3683 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AHI1 Abelson helper integration site 1
ANGPTL2 angiopoietin-like 2
ANK2 ankyrin 2, neuronal
APC2 adenomatosis polyposis coli 2
ARMC4 armadillo repeat containing 4
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
AVIL advillin
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BAZ2A bromodomain adjacent to zinc finger domain, 2A
C6 complement component 6
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CCR2 chemokine (C-C motif) receptor 2
CFAP74 cilia and flagella associated protein 74
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLEC7A C-type lectin domain family 7, member A
COL7A1 collagen, type VII, alpha 1
CREBZF CREB/ATF bZIP transcription factor
CRHR2 corticotropin releasing hormone receptor 2
CYBA cytochrome b-245, alpha polypeptide
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DCLK2 doublecortin-like kinase 2
DCTN2 dynactin 2 (p50)
DHRS12 dehydrogenase/reductase (SDR family) member 12
DSCC1 DNA replication and sister chromatid cohesion 1
DUSP1 dual specificity phosphatase 1
EPS8L1 EPS8-like 1
FAM63A family with sequence similarity 63, member A
FBXO21 F-box protein 21
FLJ11710 uncharacterized protein FLJ11710
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GFI1 growth factor independent 1 transcription repressor
GGT1 gamma-glutamyltransferase 1
GPC3 glypican 3
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPR27 G protein-coupled receptor 27
GRIK2 glutamate receptor, ionotropic, kainate 2
GRM8 glutamate receptor, metabotropic 8
GTDC1 glycosyltransferase-like domain containing 1
GTPBP1 GTP binding protein 1
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HIST1H2AB histone cluster 1, H2ab
HR hair growth associated
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KAZN kazrin, periplakin interacting protein
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
MC5R melanocortin 5 receptor
MEF2D myocyte enhancer factor 2D
MEOX1 mesenchyme homeobox 1
MMP11 matrix metallopeptidase 11
MST1L macrophage stimulating 1-like
MT4 metallothionein 4
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYO15A myosin XVA
MYO9B myosin IXB
MYT1 myelin transcription factor 1
NPTXR neuronal pentraxin receptor
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR5A2 nuclear receptor subfamily 5, group A, member 2
NRP1 neuropilin 1
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
ODAM odontogenic, ameloblast asssociated
OVOL1 ovo-like zinc finger 1
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PGAM2 phosphoglycerate mutase 2 (muscle)
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLA2G1B phospholipase A2, group IB (pancreas)
PLXDC1 plexin domain containing 1
PMFBP1 polyamine modulated factor 1 binding protein 1
PRUNE2 prune homolog 2 (Drosophila)
PTEN phosphatase and tensin homolog
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB26 RAB26, member RAS oncogene family
RAB5C RAB5C, member RAS oncogene family
RDH5 retinol dehydrogenase 5 (11-cis/9-cis)
RHEB Ras homolog enriched in brain
RYR3 ryanodine receptor 3
SERHL2 serine hydrolase-like 2
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SFTPB surfactant protein B
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SOCS7 suppressor of cytokine signaling 7
SPANXC SPANX family, member C
SPHK2 sphingosine kinase 2
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TLX1 T-cell leukemia homeobox 1
TP53 tumor protein p53
TTLL5 tubulin tyrosine ligase-like family member 5
TXK TXK tyrosine kinase
ULBP1 UL16 binding protein 1
ZBED2 zinc finger, BED-type containing 2
ZBTB7A zinc finger and BTB domain containing 7A

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALPK1 alpha-kinase 1
AMDHD2 amidohydrolase domain containing 2
AMT aminomethyltransferase
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
C1ORF105 chromosome 1 open reading frame 105
C4ORF19 chromosome 4 open reading frame 19
CCNT1 cyclin T1
CES3 carboxylesterase 3
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CISH cytokine inducible SH2-containing protein
CLK1 CDC-like kinase 1
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DMBT1 deleted in malignant brain tumors 1
DNAAF2 dynein, axonemal, assembly factor 2
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EDC4 enhancer of mRNA decapping 4
EPHX2 epoxide hydrolase 2, cytoplasmic
F3 coagulation factor III (thromboplastin, tissue factor)
FAM120C family with sequence similarity 120C
FANCC Fanconi anemia, complementation group C
FANCE Fanconi anemia, complementation group E
FBXL7 F-box and leucine-rich repeat protein 7
FGL1 fibrinogen-like 1
FRS3 fibroblast growth factor receptor substrate 3
FURIN furin (paired basic amino acid cleaving enzyme)
GMEB1 glucocorticoid modulatory element binding protein 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GRPR gastrin-releasing peptide receptor
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HIST1H1D histone cluster 1, H1d
HIST1H4C histone cluster 1, H4c
IFI6 interferon, alpha-inducible protein 6
IMPACT impact RWD domain protein
IRAK4 interleukin-1 receptor-associated kinase 4
JAM3 junctional adhesion molecule 3
KIAA1551 KIAA1551
LIG4 ligase IV, DNA, ATP-dependent
LIMD2 LIM domain containing 2
LINC00260 long intergenic non-protein coding RNA 260
LOC100286895 cell division cycle 27 homolog pseudogene
LRP5L low density lipoprotein receptor-related protein 5-like
MAGEA5 melanoma antigen family A5
MBTPS2 membrane-bound transcription factor peptidase, site 2
MFGE8 milk fat globule-EGF factor 8 protein
MPI mannose phosphate isomerase
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL44 mitochondrial ribosomal protein L44
MTA2 metastasis associated 1 family, member 2
NEK11 NIMA-related kinase 11
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
PAQR4 progestin and adipoQ receptor family member IV
PDZK1 PDZ domain containing 1
PGP phosphoglycolate phosphatase
PGPEP1 pyroglutamyl-peptidase I
PICK1 protein interacting with PRKCA 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PRAMEF11 PRAME family member 11
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRF1 perforin 1 (pore forming protein)
PWAR5 Prader Willi/Angelman region RNA 5
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RABL6 RAB, member RAS oncogene family-like 6
RNF122 ring finger protein 122
RNF170 ring finger protein 170
RPA4 replication protein A4, 30kDa
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SAMD9 sterile alpha motif domain containing 9
SCGB2A2 secretoglobin, family 2A, member 2
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC46A3 solute carrier family 46, member 3
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMO smoothened, frizzled class receptor
SRD5A3 steroid 5 alpha-reductase 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TFCP2L1 transcription factor CP2-like 1
TLR2 toll-like receptor 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM180 transmembrane protein 180
TPK1 thiamin pyrophosphokinase 1
UNC119 unc-119 homolog (C. elegans)
USP20 ubiquitin specific peptidase 20
WDR4 WD repeat domain 4
WFDC2 WAP four-disulfide core domain 2
ZBTB22 zinc finger and BTB domain containing 22
ZFP30 ZFP30 zinc finger protein
ZMAT5 zinc finger, matrin-type 5
ZNF264 zinc finger protein 264
ZNF329 zinc finger protein 329
ZNF552 zinc finger protein 552
ZNF611 zinc finger protein 611
ZNF749 zinc finger protein 749
ZNF76 zinc finger protein 76