Prestwick-682-6638 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the Prestwick-682-6638 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ACVRL1 activin A receptor type II-like 1
ADAM23 ADAM metallopeptidase domain 23
ALDOB aldolase B, fructose-bisphosphate
AMACR alpha-methylacyl-CoA racemase
ATF7IP activating transcription factor 7 interacting protein
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
B3GAT1 beta-1,3-glucuronyltransferase 1
BEX1 brain expressed, X-linked 1
C3AR1 complement component 3a receptor 1
CACNG5 calcium channel, voltage-dependent, gamma subunit 5
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CD58 CD58 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CNN1 calponin 1, basic, smooth muscle
CRHR2 corticotropin releasing hormone receptor 2
CSHL1 chorionic somatomammotropin hormone-like 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYTH1 cytohesin 1
DUSP2 dual specificity phosphatase 2
ESR1 estrogen receptor 1
FCMR Fc fragment of IgM receptor
FGFR2 fibroblast growth factor receptor 2
FRMD4B FERM domain containing 4B
GAS7 growth arrest-specific 7
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR135 G protein-coupled receptor 135
HABP4 hyaluronan binding protein 4
HFE hemochromatosis
HIST1H2BM histone cluster 1, H2bm
HMG20B high mobility group 20B
HMHB1 histocompatibility (minor) HB-1
HSPB6 heat shock protein, alpha-crystallin-related, B6
IGHA1 immunoglobulin heavy constant alpha 1
IGHD immunoglobulin heavy constant delta
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KLF1 Kruppel-like factor 1 (erythroid)
KLF13 Kruppel-like factor 13
KLK13 kallikrein-related peptidase 13
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LMX1B LIM homeobox transcription factor 1, beta
LRRN3 leucine rich repeat neuronal 3
MED25 mediator complex subunit 25
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MPZ myelin protein zero
MTMR3 myotubularin related protein 3
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NMUR1 neuromedin U receptor 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NRF1 nuclear respiratory factor 1
NRXN3 neurexin 3
NUP88 nucleoporin 88kDa
NXF2 nuclear RNA export factor 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OLFM4 olfactomedin 4
OSGIN2 oxidative stress induced growth inhibitor family member 2
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARP8 poly (ADP-ribose) polymerase family, member 8
PCDHB3 protocadherin beta 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PECAM1 platelet/endothelial cell adhesion molecule 1
PEX26 peroxisomal biogenesis factor 26
PEX3 peroxisomal biogenesis factor 3
PKD2L2 polycystic kidney disease 2-like 2
POU1F1 POU class 1 homeobox 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PRSS50 protease, serine, 50
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTRF polymerase I and transcript release factor
RGR retinal G protein coupled receptor
RGS12 regulator of G-protein signaling 12
RGS6 regulator of G-protein signaling 6
RPLP2 ribosomal protein, large, P2
SCN2B sodium channel, voltage gated, type II beta subunit
SCUBE3 signal peptide, CUB domain, EGF-like 3
SFTPA2 surfactant protein A2
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SNN stannin
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SSX1 synovial sarcoma, X breakpoint 1
SYT13 synaptotagmin XIII
TACR1 tachykinin receptor 1
TCF12 transcription factor 12
THPO thrombopoietin
TMPRSS4 transmembrane protease, serine 4
TTC12 tetratricopeptide repeat domain 12
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UPK3B uroplakin 3B
WNT1 wingless-type MMTV integration site family, member 1
ZNF484 zinc finger protein 484

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ACKR3 atypical chemokine receptor 3
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADGRF1 adhesion G protein-coupled receptor F1
ADTRP androgen-dependent TFPI-regulating protein
AMT aminomethyltransferase
APH1B APH1B gamma secretase subunit
BEND5 BEN domain containing 5
BEX4 brain expressed, X-linked 4
C14ORF79 chromosome 14 open reading frame 79
C22ORF29 chromosome 22 open reading frame 29
C4ORF29 chromosome 4 open reading frame 29
CCDC94 coiled-coil domain containing 94
CCNO cyclin O
CIDEC cell death-inducing DFFA-like effector c
CNN2 calponin 2
CTC1 CTS telomere maintenance complex component 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DDN dendrin
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DNAH17 dynein, axonemal, heavy chain 17
EN2 engrailed homeobox 2
ERCC4 excision repair cross-complementation group 4
ERN2 endoplasmic reticulum to nucleus signaling 2
FANCC Fanconi anemia, complementation group C
FBRS fibrosin
FBXO2 F-box protein 2
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLS2 glutaminase 2 (liver, mitochondrial)
GRAMD1C GRAM domain containing 1C
GUSBP3 glucuronidase, beta pseudogene 3
HDAC5 histone deacetylase 5
HIST1H2AK histone cluster 1, H2ak
HOXA4 homeobox A4
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IQSEC2 IQ motif and Sec7 domain 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
KIAA0319L KIAA0319-like
KIAA0922 KIAA0922
KLF2 Kruppel-like factor 2
KPNA5 karyopherin alpha 5 (importin alpha 6)
LIPG lipase, endothelial
LRRC37A3 leucine rich repeat containing 37, member A3
MAGEA6 melanoma antigen family A6
MDM4 MDM4, p53 regulator
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MFSD12 major facilitator superfamily domain containing 12
MLYCD malonyl-CoA decarboxylase
NPFFR1 neuropeptide FF receptor 1
NT5M 5',3'-nucleotidase, mitochondrial
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PCOLCE procollagen C-endopeptidase enhancer
PICK1 protein interacting with PRKCA 1
PID1 phosphotyrosine interaction domain containing 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLD2 phospholipase D2
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLL polymerase (DNA directed), lambda
PRAME preferentially expressed antigen in melanoma
PRSS8 protease, serine, 8
RAB17 RAB17, member RAS oncogene family
RIBC2 RIB43A domain with coiled-coils 2
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SYCP2 synaptonemal complex protein 2
TAOK1 TAO kinase 1
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
THRAP3 thyroid hormone receptor associated protein 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMC6 transmembrane channel-like 6
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TPCN1 two pore segment channel 1
TRIM16 tripartite motif containing 16
TRIM66 tripartite motif containing 66
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TUBA4B tubulin, alpha 4b
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
TWISTNB TWIST neighbor
WDR62 WD repeat domain 62
WDR76 WD repeat domain 76
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XYLT2 xylosyltransferase II
ZBTB22 zinc finger and BTB domain containing 22
ZNF227 zinc finger protein 227
ZNF286A zinc finger protein 286A
ZNF528 zinc finger protein 528
ZNF549 zinc finger protein 549
ZNF611 zinc finger protein 611
ZNF652 zinc finger protein 652
ZNF675 zinc finger protein 675
ZNF767P zinc finger family member 767, pseudogene
ZNF768 zinc finger protein 768