Prestwick-682-4984 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the Prestwick-682-4984 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
APAF1 apoptotic peptidase activating factor 1
APOLD1 apolipoprotein L domain containing 1
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BMP5 bone morphogenetic protein 5
C17ORF59 chromosome 17 open reading frame 59
C1QB complement component 1, q subcomponent, B chain
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C20ORF27 chromosome 20 open reading frame 27
CABIN1 calcineurin binding protein 1
CAMK1 calcium/calmodulin-dependent protein kinase I
CCDC85C coiled-coil domain containing 85C
CD70 CD70 molecule
CD82 CD82 molecule
CDK20 cyclin-dependent kinase 20
CRMP1 collapsin response mediator protein 1
CTC1 CTS telomere maintenance complex component 1
CXCR4 chemokine (C-X-C motif) receptor 4
DGCR2 DiGeorge syndrome critical region gene 2
DIO2 deiodinase, iodothyronine, type II
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DSPP dentin sialophosphoprotein
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EGFR epidermal growth factor receptor
ELK1 ELK1, member of ETS oncogene family
ENO3 enolase 3 (beta, muscle)
ERAP1 endoplasmic reticulum aminopeptidase 1
FBLN1 fibulin 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GJA4 gap junction protein, alpha 4, 37kDa
GPER1 G protein-coupled estrogen receptor 1
GPR137 G protein-coupled receptor 137
GSN gelsolin
HCRP1 hepatocellular carcinoma-related HCRP1
HIST1H2AJ histone cluster 1, H2aj
HIST1H3F histone cluster 1, H3f
HPX hemopexin
ING2 inhibitor of growth family, member 2
IRF8 interferon regulatory factor 8
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNIP1 Kv channel interacting protein 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLHL22 kelch-like family member 22
KMT2A lysine (K)-specific methyltransferase 2A
LAT2 linker for activation of T cells family, member 2
LYPLA2P1 lysophospholipase II pseudogene 1
MAL mal, T-cell differentiation protein
MAP1A microtubule-associated protein 1A
MAPK10 mitogen-activated protein kinase 10
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARK2 MAP/microtubule affinity-regulating kinase 2
MAST3 microtubule associated serine/threonine kinase 3
MRPS18C mitochondrial ribosomal protein S18C
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NDRG2 NDRG family member 2
NEUROD1 neuronal differentiation 1
NF2 neurofibromin 2 (merlin)
NR2F1 nuclear receptor subfamily 2, group F, member 1
PCDHGB5 protocadherin gamma subfamily B, 5
PCNX pecanex homolog (Drosophila)
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PIGR polymeric immunoglobulin receptor
PLAU plasminogen activator, urokinase
PLEKHS1 pleckstrin homology domain containing, family S member 1
POPDC3 popeye domain containing 3
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP5C protein phosphatase 5, catalytic subunit
PRDX2 peroxiredoxin 2
PRF1 perforin 1 (pore forming protein)
PRSS22 protease, serine, 22
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RUNDC3A RUN domain containing 3A
S100A7 S100 calcium binding protein A7
SCG2 secretogranin II
SFXN1 sideroflexin 1
SIDT2 SID1 transmembrane family, member 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SMC4 structural maintenance of chromosomes 4
SOGA1 suppressor of glucose, autophagy associated 1
SPX spexin hormone
SRSF7 serine/arginine-rich splicing factor 7
STRA6 stimulated by retinoic acid 6
TBXA2R thromboxane A2 receptor
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TPMT thiopurine S-methyltransferase
TSC22D4 TSC22 domain family, member 4
VIPR1 vasoactive intestinal peptide receptor 1
VWA5A von Willebrand factor A domain containing 5A
WIZ widely interspaced zinc finger motifs
ZNF224 zinc finger protein 224
ZNF493 zinc finger protein 493
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACTL8 actin-like 8
ALPK1 alpha-kinase 1
AMT aminomethyltransferase
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ASPHD1 aspartate beta-hydroxylase domain containing 1
C5ORF45 chromosome 5 open reading frame 45
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CEP85 centrosomal protein 85kDa
CIC capicua transcriptional repressor
CLDN1 claudin 1
CLDN15 claudin 15
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DVL1 dishevelled segment polarity protein 1
FAM169A family with sequence similarity 169, member A
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRK fyn-related Src family tyrosine kinase
FRMD1 FERM domain containing 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATA4 GATA binding protein 4
GEMIN8 gem (nuclear organelle) associated protein 8
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPATCH2L G patch domain containing 2-like
HCAR3 hydroxycarboxylic acid receptor 3
HOXC10 homeobox C10
HOXC13 homeobox C13
HSPA1L heat shock 70kDa protein 1-like
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IL22 interleukin 22
INSIG2 insulin induced gene 2
ITGA10 integrin, alpha 10
KIAA0754 KIAA0754
KRT13 keratin 13, type I
LRP5L low density lipoprotein receptor-related protein 5-like
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MICALL2 MICAL-like 2
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MON1B MON1 secretory trafficking family member B
MVP major vault protein
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPIPB15 nuclear pore complex interacting protein family, member B15
PAIP2B poly(A) binding protein interacting protein 2B
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PTPN14 protein tyrosine phosphatase, non-receptor type 14
RAB3A RAB3A, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RGS2 regulator of G-protein signaling 2
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF31 ring finger protein 31
RNF39 ring finger protein 39
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPAP1 RNA polymerase II associated protein 1
SIX1 SIX homeobox 1
SLC12A8 solute carrier family 12, member 8
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC35F5 solute carrier family 35, member F5
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SYCP2 synaptonemal complex protein 2
SYT17 synaptotagmin XVII
TAOK1 TAO kinase 1
TARP TCR gamma alternate reading frame protein
TBX19 T-box 19
TCTN1 tectonic family member 1
TESC tescalcin
TET3 tet methylcytosine dioxygenase 3
THBS3 thrombospondin 3
TMEM104 transmembrane protein 104
TMEM183A transmembrane protein 183A
TPCN1 two pore segment channel 1
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSGA10 testis specific, 10
WLS wntless Wnt ligand secretion mediator
XYLT2 xylosyltransferase II
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
ZNF16 zinc finger protein 16
ZNF37BP zinc finger protein 37B, pseudogene
ZNF510 zinc finger protein 510
ZNF573 zinc finger protein 573
ZNF606 zinc finger protein 606
ZNF767P zinc finger family member 767, pseudogene
ZNF770 zinc finger protein 770
ZSCAN31 zinc finger and SCAN domain containing 31