Prestwick-675-7381 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the Prestwick-675-7381 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AMPD3 adenosine monophosphate deaminase 3
AMPH amphiphysin
ARL14 ADP-ribosylation factor-like 14
ATF7IP activating transcription factor 7 interacting protein
AXIN1 axin 1
BRCA1 breast cancer 1, early onset
CABIN1 calcineurin binding protein 1
CCNT2 cyclin T2
CDC14B cell division cycle 14B
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CLDN11 claudin 11
CNN1 calponin 1, basic, smooth muscle
COPA coatomer protein complex, subunit alpha
CRYL1 crystallin, lambda 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DHODH dihydroorotate dehydrogenase (quinone)
DPP4 dipeptidyl-peptidase 4
E2F4 E2F transcription factor 4, p107/p130-binding
FGFR1 fibroblast growth factor receptor 1
FKBP8 FK506 binding protein 8, 38kDa
FUZ fuzzy planar cell polarity protein
FYB FYN binding protein
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GLS2 glutaminase 2 (liver, mitochondrial)
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GPC3 glypican 3
GPR137 G protein-coupled receptor 137
GUK1 guanylate kinase 1
HIST1H2BN histone cluster 1, H2bn
HIST1H3I histone cluster 1, H3i
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IL32 interleukin 32
ING4 inhibitor of growth family, member 4
ITGB5 integrin, beta 5
KANSL3 KAT8 regulatory NSL complex subunit 3
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LEF1 lymphoid enhancer-binding factor 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LINC00597 long intergenic non-protein coding RNA 597
LOXL2 lysyl oxidase-like 2
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MED16 mediator complex subunit 16
MED18 mediator complex subunit 18
MIIP migration and invasion inhibitory protein
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMRN2 multimerin 2
MR1 major histocompatibility complex, class I-related
MTA1 metastasis associated 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NF2 neurofibromin 2 (merlin)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NNMT nicotinamide N-methyltransferase
NOP14-AS1 NOP14 antisense RNA 1
NOS1 nitric oxide synthase 1 (neuronal)
NPAS1 neuronal PAS domain protein 1
NPR3 natriuretic peptide receptor 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
PHLDB1 pleckstrin homology-like domain, family B, member 1
PLCD1 phospholipase C, delta 1
PLCG1 phospholipase C, gamma 1
PMP2 peripheral myelin protein 2
PODNL1 podocan-like 1
PSG9 pregnancy specific beta-1-glycoprotein 9
PTCRA pre T-cell antigen receptor alpha
PTEN phosphatase and tensin homolog
PTGER3 prostaglandin E receptor 3 (subtype EP3)
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB6B RAB6B, member RAS oncogene family
RBMS2 RNA binding motif, single stranded interacting protein 2
RGS10 regulator of G-protein signaling 10
RIN3 Ras and Rab interactor 3
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RPL7 ribosomal protein L7
RUSC2 RUN and SH3 domain containing 2
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SEPP1 selenoprotein P, plasma, 1
SLC16A6 solute carrier family 16, member 6
SLC44A1 solute carrier family 44 (choline transporter), member 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SOD3 superoxide dismutase 3, extracellular
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRPX2 sushi-repeat containing protein, X-linked 2
STAT2 signal transducer and activator of transcription 2, 113kDa
STK3 serine/threonine kinase 3
SUGP1 SURP and G patch domain containing 1
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE4 transducin-like enhancer of split 4
TOP3B topoisomerase (DNA) III beta
TRIM2 tripartite motif containing 2
TRIM25 tripartite motif containing 25
TTC38 tetratricopeptide repeat domain 38
UBE3B ubiquitin protein ligase E3B
UBQLN4 ubiquilin 4
VIPR2 vasoactive intestinal peptide receptor 2
WDR33 WD repeat domain 33
ZNF197 zinc finger protein 197
ZNF219 zinc finger protein 219
ZNF222 zinc finger protein 222

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ABHD17B abhydrolase domain containing 17B
ABHD8 abhydrolase domain containing 8
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARMC6 armadillo repeat containing 6
ATP10D ATPase, class V, type 10D
ATP13A2 ATPase type 13A2
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
C1QTNF1 C1q and tumor necrosis factor related protein 1
C7ORF43 chromosome 7 open reading frame 43
CALCOCO1 calcium binding and coiled-coil domain 1
CCDC68 coiled-coil domain containing 68
CD70 CD70 molecule
CDK3 cyclin-dependent kinase 3
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEP70 centrosomal protein 70kDa
CHD8 chromodomain helicase DNA binding protein 8
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLEC10A C-type lectin domain family 10, member A
CLEC16A C-type lectin domain family 16, member A
CTSK cathepsin K
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DENND1A DENN/MADD domain containing 1A
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNMBP dynamin binding protein
EML4 echinoderm microtubule associated protein like 4
EN2 engrailed homeobox 2
EPN3 epsin 3
EVPL envoplakin
EXOC3 exocyst complex component 3
FAM160B2 family with sequence similarity 160, member B2
FCHSD2 FCH and double SH3 domains 2
FHOD1 formin homology 2 domain containing 1
FSD1 fibronectin type III and SPRY domain containing 1
GAB2 GRB2-associated binding protein 2
GALK1 galactokinase 1
GLCE glucuronic acid epimerase
GPBP1L1 GC-rich promoter binding protein 1-like 1
GRAMD4 GRAM domain containing 4
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AM histone cluster 1, H2am
HIST1H3G histone cluster 1, H3g
INPP5K inositol polyphosphate-5-phosphatase K
ISL1 ISL LIM homeobox 1
KDM5C lysine (K)-specific demethylase 5C
KIAA1462 KIAA1462
KRT34 keratin 34, type I
KRT6A keratin 6A, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRC61 leucine rich repeat containing 61
LZTFL1 leucine zipper transcription factor-like 1
MANBA mannosidase, beta A, lysosomal
MB myoglobin
MMP1 matrix metallopeptidase 1
MOXD1 monooxygenase, DBH-like 1
NCS1 neuronal calcium sensor 1
NDE1 nudE neurodevelopment protein 1
NECAP2 NECAP endocytosis associated 2
NID2 nidogen 2 (osteonidogen)
NINL ninein-like
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NXPH4 neurexophilin 4
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PIAS3 protein inhibitor of activated STAT, 3
PPP1R13B protein phosphatase 1, regulatory subunit 13B
RASA2 RAS p21 protein activator 2
RNF2 ring finger protein 2
RUNX1-IT1 RUNX1 intronic transcript 1
SCAMP5 secretory carrier membrane protein 5
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL2 SH3-domain GRB2-like 2
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TEP1 telomerase-associated protein 1
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM2 transmembrane protein 2
TMEM53 transmembrane protein 53
TMEM8B transmembrane protein 8B
TPCN1 two pore segment channel 1
TSPAN12 tetraspanin 12
TUBA3C tubulin, alpha 3c
ULBP2 UL16 binding protein 2
VEGFB vascular endothelial growth factor B
VWA1 von Willebrand factor A domain containing 1
ZBTB3 zinc finger and BTB domain containing 3
ZBTB39 zinc finger and BTB domain containing 39
ZNF10 zinc finger protein 10
ZNF204P zinc finger protein 204, pseudogene
ZNF253 zinc finger protein 253
ZNF350 zinc finger protein 350
ZNF767P zinc finger family member 767, pseudogene
ZXDC ZXD family zinc finger C