Prestwick-675-2187 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the Prestwick-675-2187 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABLIM1 actin binding LIM protein 1
ACOT7 acyl-CoA thioesterase 7
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ACTC1 actin, alpha, cardiac muscle 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
B9D1 B9 protein domain 1
BIN1 bridging integrator 1
BMP1 bone morphogenetic protein 1
BTN3A1 butyrophilin, subfamily 3, member A1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF1 chromosome 14 open reading frame 1
C1ORF95 chromosome 1 open reading frame 95
C4ORF19 chromosome 4 open reading frame 19
CD200 CD200 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK10 cyclin-dependent kinase 10
CLTA clathrin, light chain A
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DCHS2 dachsous cadherin-related 2
DCTN2 dynactin 2 (p50)
DEFA4 defensin, alpha 4, corticostatin
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DLK2 delta-like 2 homolog (Drosophila)
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DPT dermatopontin
EGR4 early growth response 4
FBXO4 F-box protein 4
FLOT1 flotillin 1
FOXP3 forkhead box P3
FRS3 fibroblast growth factor receptor substrate 3
FURIN furin (paired basic amino acid cleaving enzyme)
GJA9 gap junction protein, alpha 9, 59kDa
GJC2 gap junction protein, gamma 2, 47kDa
GP5 glycoprotein V (platelet)
GSTA1 glutathione S-transferase alpha 1
GTPBP1 GTP binding protein 1
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HFE hemochromatosis
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOMER3 homer scaffolding protein 3
HSF1 heat shock transcription factor 1
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IDI2-AS1 IDI2 antisense RNA 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL10 interleukin 10
IL1R2 interleukin 1 receptor, type II
INPP5K inositol polyphosphate-5-phosphatase K
KDM8 lysine (K)-specific demethylase 8
KL klotho
LAMP1 lysosomal-associated membrane protein 1
LTB4R leukotriene B4 receptor
MAGEA5 melanoma antigen family A5
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP4 microtubule-associated protein 4
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MMP7 matrix metallopeptidase 7
NEU3 sialidase 3 (membrane sialidase)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
PADI4 peptidyl arginine deiminase, type IV
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PAPPA2 pappalysin 2
PCDHGA8 protocadherin gamma subfamily A, 8
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PLCH1 phospholipase C, eta 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PYCRL pyrroline-5-carboxylate reductase-like
PYGB phosphorylase, glycogen; brain
RB1 retinoblastoma 1
RBMY2FP RNA binding motif protein, Y-linked, family 2, member F pseudogene
RHOC ras homolog family member C
SCHIP1 schwannomin interacting protein 1
SERHL2 serine hydrolase-like 2
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SP110 SP110 nuclear body protein
SYN2 synapsin II
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TFF2 trefoil factor 2
TNNI3 troponin I type 3 (cardiac)
TPM1 tropomyosin 1 (alpha)
TRIM15 tripartite motif containing 15
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TSPAN4 tetraspanin 4
ZC3H7B zinc finger CCCH-type containing 7B
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
AHCTF1 AT hook containing transcription factor 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BBC3 BCL2 binding component 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTBD18 BTB (POZ) domain containing 18
C11ORF21 chromosome 11 open reading frame 21
CAMKMT calmodulin-lysine N-methyltransferase
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CBX7 chromobox homolog 7
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDH10 cadherin 10, type 2 (T2-cadherin)
CFP complement factor properdin
CHMP6 charged multivesicular body protein 6
CIDEB cell death-inducing DFFA-like effector b
CNTLN centlein, centrosomal protein
COL9A2 collagen, type IX, alpha 2
CORT cortistatin
CTSD cathepsin D
ELP6 elongator acetyltransferase complex subunit 6
EPHA4 EPH receptor A4
EPHB6 EPH receptor B6
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM63A family with sequence similarity 63, member A
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FES FES proto-oncogene, tyrosine kinase
FMOD fibromodulin
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FSTL3 follistatin-like 3 (secreted glycoprotein)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR22 G protein-coupled receptor 22
GPR27 G protein-coupled receptor 27
GRPR gastrin-releasing peptide receptor
HCFC2 host cell factor C2
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2AM histone cluster 1, H2am
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HPSE heparanase
HS1BP3 HCLS1 binding protein 3
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
KIAA0754 KIAA0754
KIAA1107 KIAA1107
KRT8P12 keratin 8 pseudogene 12
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LINC00597 long intergenic non-protein coding RNA 597
LNPEP leucyl/cystinyl aminopeptidase
LRP2 low density lipoprotein receptor-related protein 2
LY6E lymphocyte antigen 6 complex, locus E
MAK male germ cell-associated kinase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PARG poly (ADP-ribose) glycohydrolase
PCDHGA10 protocadherin gamma subfamily A, 10
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma
PHACTR1 phosphatase and actin regulator 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PIAS3 protein inhibitor of activated STAT, 3
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
RAB3A RAB3A, member RAS oncogene family
RFPL3 ret finger protein-like 3
RFXAP regulatory factor X-associated protein
RHOB ras homolog family member B
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF2 ring finger protein 2
RPL13P5 ribosomal protein L13 pseudogene 5
SIK1 salt-inducible kinase 1
SLC12A9 solute carrier family 12, member 9
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC22A14 solute carrier family 22, member 14
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SP1 Sp1 transcription factor
SPATA1 spermatogenesis associated 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STAT5A signal transducer and activator of transcription 5A
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TIAM2 T-cell lymphoma invasion and metastasis 2
TIGD6 tigger transposable element derived 6
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM209 transmembrane protein 209
TMEM8A transmembrane protein 8A
TRAF1 TNF receptor-associated factor 1
TTC23 tetratricopeptide repeat domain 23
TUBA4B tubulin, alpha 4b
ULK1 unc-51 like autophagy activating kinase 1
VN1R1 vomeronasal 1 receptor 1
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR62 WD repeat domain 62
ZC3H12A zinc finger CCCH-type containing 12A
ZC4H2 zinc finger, C4H2 domain containing
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF197 zinc finger protein 197