Prestwick-674-3614 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the Prestwick-674-3614 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
AMPD3 adenosine monophosphate deaminase 3
APAF1 apoptotic peptidase activating factor 1
APCS amyloid P component, serum
AQP1 aquaporin 1 (Colton blood group)
B9D2 B9 protein domain 2
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BIN1 bridging integrator 1
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CALCA calcitonin-related polypeptide alpha
CALD1 caldesmon 1
CCDC40 coiled-coil domain containing 40
CCL5 chemokine (C-C motif) ligand 5
CD36 CD36 molecule (thrombospondin receptor)
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CPQ carboxypeptidase Q
CTRB2 chymotrypsinogen B2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYTH4 cytohesin 4
DIAPH2-AS1 DIAPH2 antisense RNA 1
DOCK6 dedicator of cytokinesis 6
DPY19L2P2 DPY19L2 pseudogene 2
EFNB3 ephrin-B3
GDF5 growth differentiation factor 5
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GRM1 glutamate receptor, metabotropic 1
HBS1L HBS1-like translational GTPase
HEPH hephaestin
HIF3A hypoxia inducible factor 3, alpha subunit
HOXA11 homeobox A11
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IGHM immunoglobulin heavy constant mu
IGLJ3 immunoglobulin lambda joining 3
IL23A interleukin 23, alpha subunit p19
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KRT8 keratin 8, type II
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LMO7 LIM domain 7
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MARK4 MAP/microtubule affinity-regulating kinase 4
MAU2 MAU2 sister chromatid cohesion factor
MED25 mediator complex subunit 25
MFSD6 major facilitator superfamily domain containing 6
MKL1 megakaryoblastic leukemia (translocation) 1
MLXIPL MLX interacting protein-like
MORN1 MORN repeat containing 1
MSLN mesothelin
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NCAPH2 non-SMC condensin II complex, subunit H2
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NF1 neurofibromin 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NUP214 nucleoporin 214kDa
OR1E1 olfactory receptor, family 1, subfamily E, member 1
OR2H2 olfactory receptor, family 2, subfamily H, member 2
OR7E24 olfactory receptor, family 7, subfamily E, member 24
OSBPL10 oxysterol binding protein-like 10
OTOR otoraplin
PALM paralemmin
PARP3 poly (ADP-ribose) polymerase family, member 3
PDLIM7 PDZ and LIM domain 7 (enigma)
PF4 platelet factor 4
PHLDB1 pleckstrin homology-like domain, family B, member 1
PKP2 plakophilin 2
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLAC1 placenta-specific 1
PLLP plasmolipin
POU2F2 POU class 2 homeobox 2
POU3F1 POU class 3 homeobox 1
PQLC2 PQ loop repeat containing 2
PRDM10 PR domain containing 10
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRSS3 protease, serine, 3
PSG4 pregnancy specific beta-1-glycoprotein 4
RAB3B RAB3B, member RAS oncogene family
RAD52 RAD52 homolog (S. cerevisiae)
RHBG Rh family, B glycoprotein (gene/pseudogene)
RNF17 ring finger protein 17
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RUNX1 runt-related transcription factor 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
STXBP5L syntaxin binding protein 5-like
SV2A synaptic vesicle glycoprotein 2A
TCEAL2 transcription elongation factor A (SII)-like 2
TCL1B T-cell leukemia/lymphoma 1B
TMEM63A transmembrane protein 63A
TNF tumor necrosis factor
UMPS uridine monophosphate synthetase
USP2 ubiquitin specific peptidase 2
WNT10B wingless-type MMTV integration site family, member 10B
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
ZNF154 zinc finger protein 154
ZNF446 zinc finger protein 446
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ACTL8 actin-like 8
AHNAK2 AHNAK nucleoprotein 2
AIRE autoimmune regulator
ALOX15 arachidonate 15-lipoxygenase
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
AXIN1 axin 1
BAG4 BCL2-associated athanogene 4
BAHCC1 BAH domain and coiled-coil containing 1
C11ORF21 chromosome 11 open reading frame 21
C9ORF9 chromosome 9 open reading frame 9
CAPN5 calpain 5
CGA glycoprotein hormones, alpha polypeptide
CGREF1 cell growth regulator with EF-hand domain 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CORT cortistatin
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRY2 cryptochrome circadian clock 2
CUZD1 CUB and zona pellucida-like domains 1
CXXC4 CXXC finger protein 4
DGKE diacylglycerol kinase, epsilon 64kDa
DNM1 dynamin 1
DOC2A double C2-like domains, alpha
DOK5 docking protein 5
EPN1 epsin 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM155A family with sequence similarity 155, member A
FAM212B family with sequence similarity 212, member B
FAM46C family with sequence similarity 46, member C
FBXL7 F-box and leucine-rich repeat protein 7
GLDC glycine dehydrogenase (decarboxylating)
GLS2 glutaminase 2 (liver, mitochondrial)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GSTCD glutathione S-transferase, C-terminal domain containing
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H4A histone cluster 1, H4a
HIST1H4F histone cluster 1, H4f
HOXA4 homeobox A4
HOXB2 homeobox B2
IFNA17 interferon, alpha 17
INF2 inverted formin, FH2 and WH2 domain containing
INPP1 inositol polyphosphate-1-phosphatase
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCTD17 potassium channel tetramerization domain containing 17
KCTD7 potassium channel tetramerization domain containing 7
KIAA0355 KIAA0355
KIF13B kinesin family member 13B
KLF2 Kruppel-like factor 2
KRBOX4 KRAB box domain containing 4
KRT15 keratin 15, type I
LIN7A lin-7 homolog A (C. elegans)
LOXL3 lysyl oxidase-like 3
METTL16 methyltransferase like 16
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MVP major vault protein
NDE1 nudE neurodevelopment protein 1
NLRX1 NLR family member X1
NME5 NME/NM23 family member 5
OLFML2A olfactomedin-like 2A
ONECUT1 one cut homeobox 1
PAQR6 progestin and adipoQ receptor family member VI
PGR progesterone receptor
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLEKHA6 pleckstrin homology domain containing, family A member 6
POLH polymerase (DNA directed), eta
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRICKLE3 prickle homolog 3 (Drosophila)
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRPH peripherin
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAD54L2 RAD54-like 2 (S. cerevisiae)
ROM1 retinal outer segment membrane protein 1
SDS serine dehydratase
SERGEF secretion regulating guanine nucleotide exchange factor
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPON2 spondin 2, extracellular matrix protein
SPRYD7 SPRY domain containing 7
STARD5 StAR-related lipid transfer (START) domain containing 5
TARP TCR gamma alternate reading frame protein
TBL1Y transducin (beta)-like 1, Y-linked
TCTN2 tectonic family member 2
TMEM53 transmembrane protein 53
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA3C tubulin, alpha 3c
USP19 ubiquitin specific peptidase 19
VASH1 vasohibin 1
YY2 YY2 transcription factor
ZNF204P zinc finger protein 204, pseudogene
ZNF350 zinc finger protein 350
ZNF41 zinc finger protein 41
ZNF532 zinc finger protein 532
ZNF747 zinc finger protein 747