Prestwick-665-4704 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

192 genes differentially expressed following the Prestwick-665-4704 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ADRBK1 adrenergic, beta, receptor kinase 1
AIRE autoimmune regulator
ALOX15 arachidonate 15-lipoxygenase
APOLD1 apolipoprotein L domain containing 1
APOM apolipoprotein M
ARNT aryl hydrocarbon receptor nuclear translocator
B9D2 B9 protein domain 2
BRS3 bombesin-like receptor 3
C1ORF54 chromosome 1 open reading frame 54
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CD101 CD101 molecule
CFHR4 complement factor H-related 4
CLCA1 chloride channel accessory 1
CREB1 cAMP responsive element binding protein 1
CRMP1 collapsin response mediator protein 1
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTRL chymotrypsin-like
CYLD cylindromatosis (turban tumor syndrome)
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DCAF11 DDB1 and CUL4 associated factor 11
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DOK4 docking protein 4
DPY19L1P1 DPY19L1 pseudogene 1
EMCN endomucin
ERO1LB ERO1-like beta (S. cerevisiae)
EZR ezrin
FBXO2 F-box protein 2
GGTLC1 gamma-glutamyltransferase light chain 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GK glycerol kinase
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HCRP1 hepatocellular carcinoma-related HCRP1
HIST1H2BC histone cluster 1, H2bc
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INCENP inner centromere protein antigens 135/155kDa
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA1107 KIAA1107
KLF6 Kruppel-like factor 6
LARP7 La ribonucleoprotein domain family, member 7
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MR1 major histocompatibility complex, class I-related
NOX1 NADPH oxidase 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR5A2 nuclear receptor subfamily 5, group A, member 2
NRF1 nuclear respiratory factor 1
OLFML2A olfactomedin-like 2A
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PCDHA6 protocadherin alpha 6
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLCB2 phospholipase C, beta 2
PRAMEF10 PRAME family member 10
PSCA prostate stem cell antigen
QKI QKI, KH domain containing, RNA binding
RAB40C RAB40C, member RAS oncogene family
RAB6A RAB6A, member RAS oncogene family
RHEB Ras homolog enriched in brain
RPGR retinitis pigmentosa GTPase regulator
RPS2 ribosomal protein S2
RRAGB Ras-related GTP binding B
RXRB retinoid X receptor, beta
SCRN3 secernin 3
SFRP4 secreted frizzled-related protein 4
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SORCS3 sortilin-related VPS10 domain containing receptor 3
SSPN sarcospan
SULT4A1 sulfotransferase family 4A, member 1
TBC1D2B TBC1 domain family, member 2B
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDRKH tudor and KH domain containing
TESC tescalcin
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLE4 transducin-like enhancer of split 4
TNS1 tensin 1
TRIM10 tripartite motif containing 10
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TTC39A tetratricopeptide repeat domain 39A
TYRP1 tyrosinase-related protein 1
YIPF4 Yip1 domain family, member 4
ZNF112 zinc finger protein 112
ZNF362 zinc finger protein 362
ZNF384 zinc finger protein 384
ZNF551 zinc finger protein 551
ZNF804A zinc finger protein 804A

decreased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
BFSP1 beaded filament structural protein 1, filensin
C1QTNF3 C1q and tumor necrosis factor related protein 3
C7ORF69 chromosome 7 open reading frame 69
CAMK1 calcium/calmodulin-dependent protein kinase I
CAMKMT calmodulin-lysine N-methyltransferase
CCDC85C coiled-coil domain containing 85C
CCDC88C coiled-coil domain containing 88C
CD79A CD79a molecule, immunoglobulin-associated alpha
CDHR2 cadherin-related family member 2
CGA glycoprotein hormones, alpha polypeptide
CLCN6 chloride channel, voltage-sensitive 6
CLSPN claspin
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DSCAM Down syndrome cell adhesion molecule
EGFL7 EGF-like-domain, multiple 7
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELP6 elongator acetyltransferase complex subunit 6
ELSPBP1 epididymal sperm binding protein 1
ERCC4 excision repair cross-complementation group 4
ERN2 endoplasmic reticulum to nucleus signaling 2
ETNK2 ethanolamine kinase 2
EXD3 exonuclease 3'-5' domain containing 3
FANCE Fanconi anemia, complementation group E
FLJ21369 uncharacterized protein FLJ21369
FSTL3 follistatin-like 3 (secreted glycoprotein)
GLRA1 glycine receptor, alpha 1
GMPR guanosine monophosphate reductase
GUSBP3 glucuronidase, beta pseudogene 3
HDAC5 histone deacetylase 5
HIRA histone cell cycle regulator
HIST1H3B histone cluster 1, H3b
HYI hydroxypyruvate isomerase (putative)
ITPKB inositol-trisphosphate 3-kinase B
JUNB jun B proto-oncogene
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KDM7A lysine (K)-specific demethylase 7A
KIAA0319L KIAA0319-like
KIAA0754 KIAA0754
KLF13 Kruppel-like factor 13
KLHL25 kelch-like family member 25
KPNA5 karyopherin alpha 5 (importin alpha 6)
KRI1 KRI1 homolog (S. cerevisiae)
KRT31 keratin 31, type I
LHX6 LIM homeobox 6
MAGOH2P mago-nashi homolog 2, pseudogene
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPKBP1 mitogen-activated protein kinase binding protein 1
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MUC3A mucin 3A, cell surface associated
MUM1 melanoma associated antigen (mutated) 1
MYLK myosin light chain kinase
NAT6 N-acetyltransferase 6 (GCN5-related)
NOL10 nucleolar protein 10
NPTX1 neuronal pentraxin I
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PARP12 poly (ADP-ribose) polymerase family, member 12
PER3 period circadian clock 3
PIDD1 p53-induced death domain protein 1
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PODXL2 podocalyxin-like 2
POLM polymerase (DNA directed), mu
POMT2 protein-O-mannosyltransferase 2
POTEKP POTE ankyrin domain family, member K, pseudogene
PRICKLE3 prickle homolog 3 (Drosophila)
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RIN1 Ras and Rab interactor 1
RPGRIP1L RPGRIP1-like
S100A9 S100 calcium binding protein A9
SAA3P serum amyloid A3 pseudogene
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SIX1 SIX homeobox 1
SKI SKI proto-oncogene
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNTA1 syntrophin, alpha 1
SPRY2 sprouty homolog 2 (Drosophila)
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STMN3 stathmin-like 3
TICAM1 toll-like receptor adaptor molecule 1
TIGD6 tigger transposable element derived 6
USB1 U6 snRNA biogenesis 1
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
ZKSCAN3 zinc finger with KRAB and SCAN domains 3