Prestwick-665-3681 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the Prestwick-665-3681 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACRV1 acrosomal vesicle protein 1
ADAMDEC1 ADAM-like, decysin 1
AGRP agouti related neuropeptide
AHSP alpha hemoglobin stabilizing protein
AIM2 absent in melanoma 2
ALOX5 arachidonate 5-lipoxygenase
ANGPTL2 angiopoietin-like 2
ARHGAP24 Rho GTPase activating protein 24
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATP10B ATPase, class V, type 10B
BDKRB2 bradykinin receptor B2
CABP2 calcium binding protein 2
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD248 CD248 molecule, endosialin
CEMIP cell migration inducing protein, hyaluronan binding
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CLTA clathrin, light chain A
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CSF1R colony stimulating factor 1 receptor
CTNNA2 catenin (cadherin-associated protein), alpha 2
CYTH3 cytohesin 3
DCAKD dephospho-CoA kinase domain containing
DDN dendrin
DENND2D DENN/MADD domain containing 2D
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DPY19L1 dpy-19-like 1 (C. elegans)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F13A1 coagulation factor XIII, A1 polypeptide
F5 coagulation factor V (proaccelerin, labile factor)
FAM174B family with sequence similarity 174, member B
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FER1L4 fer-1-like family member 4, pseudogene (functional)
FGF16 fibroblast growth factor 16
FSCN3 fascin actin-bundling protein 3, testicular
FZD1 frizzled class receptor 1
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GAL galanin/GMAP prepropeptide
HFE hemochromatosis
HHLA1 HERV-H LTR-associating 1
HLA-DOA major histocompatibility complex, class II, DO alpha
HOXD1 homeobox D1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
HUS1 HUS1 checkpoint homolog (S. pombe)
IL10 interleukin 10
IL21R interleukin 21 receptor
INHBC inhibin, beta C
IRF4 interferon regulatory factor 4
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAM2 junctional adhesion molecule 2
KIAA1109 KIAA1109
LAMP5 lysosomal-associated membrane protein family, member 5
LENEP lens epithelial protein
MEGF6 multiple EGF-like-domains 6
MMP25 matrix metallopeptidase 25
MRC2 mannose receptor, C type 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC3B mucin 3B, cell surface associated
MYO1F myosin IF
OR1F1 olfactory receptor, family 1, subfamily F, member 1
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4
PAX8 paired box 8
PIGR polymeric immunoglobulin receptor
PTCRA pre T-cell antigen receptor alpha
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAD23B RAD23 homolog B (S. cerevisiae)
RGS17 regulator of G-protein signaling 17
RPL10L ribosomal protein L10-like
RPS4Y1 ribosomal protein S4, Y-linked 1
SCN3B sodium channel, voltage gated, type III beta subunit
SCN4A sodium channel, voltage gated, type IV alpha subunit
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SH2D3A SH2 domain containing 3A
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMAD5-AS1 SMAD5 antisense RNA 1
SRSF7 serine/arginine-rich splicing factor 7
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SV2B synaptic vesicle glycoprotein 2B
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBKBP1 TBK1 binding protein 1
TESC tescalcin
TFEB transcription factor EB
THPO thrombopoietin
TIAM2 T-cell lymphoma invasion and metastasis 2
TLE6 transducin-like enhancer of split 6
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIM29 tripartite motif containing 29
TRIM31 tripartite motif containing 31
TSPAN9 tetraspanin 9
TTC12 tetratricopeptide repeat domain 12
WDR55 WD repeat domain 55
ZBTB7A zinc finger and BTB domain containing 7A
ZNF235 zinc finger protein 235
ZNF362 zinc finger protein 362

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACIN1 apoptotic chromatin condensation inducer 1
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALPK1 alpha-kinase 1
ARC activity-regulated cytoskeleton-associated protein
AURKC aurora kinase C
BAHCC1 BAH domain and coiled-coil containing 1
BBS7 Bardet-Biedl syndrome 7
BDKRB1 bradykinin receptor B1
BIRC3 baculoviral IAP repeat containing 3
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAPN5 calpain 5
CCNJL cyclin J-like
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD68 CD68 molecule
CDON cell adhesion associated, oncogene regulated
CENPO centromere protein O
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CNTFR ciliary neurotrophic factor receptor
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPPED1 calcineurin-like phosphoesterase domain containing 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
ELMO3 engulfment and cell motility 3
ENOX1 ecto-NOX disulfide-thiol exchanger 1
EPN1 epsin 1
ERAP2 endoplasmic reticulum aminopeptidase 2
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
EXOC6B exocyst complex component 6B
FAM110B family with sequence similarity 110, member B
FBXO46 F-box protein 46
FGL1 fibrinogen-like 1
FMO4 flavin containing monooxygenase 4
GALK1 galactokinase 1
GDAP1 ganglioside induced differentiation associated protein 1
GJA8 gap junction protein, alpha 8, 50kDa
GLS2 glutaminase 2 (liver, mitochondrial)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GREB1L growth regulation by estrogen in breast cancer-like
HDAC11 histone deacetylase 11
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOMER2 homer scaffolding protein 2
HOXC10 homeobox C10
HSPA1L heat shock 70kDa protein 1-like
HYI hydroxypyruvate isomerase (putative)
IDI2-AS1 IDI2 antisense RNA 1
IFT81 intraflagellar transport 81
IL22 interleukin 22
IRF2BP1 interferon regulatory factor 2 binding protein 1
KIAA0232 KIAA0232
KIAA1462 KIAA1462
KIF13B kinesin family member 13B
LIMD2 LIM domain containing 2
LIME1 Lck interacting transmembrane adaptor 1
LRRC37A3 leucine rich repeat containing 37, member A3
LRRK1 leucine-rich repeat kinase 1
LZTR1 leucine-zipper-like transcription regulator 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAN2C1 mannosidase, alpha, class 2C, member 1
MCMBP minichromosome maintenance complex binding protein
MMP3 matrix metallopeptidase 3
MX1 MX dynamin-like GTPase 1
NPFFR1 neuropeptide FF receptor 1
NT5C 5', 3'-nucleotidase, cytosolic
ODF2 outer dense fiber of sperm tails 2
PGP phosphoglycolate phosphatase
PHC1 polyhomeotic homolog 1 (Drosophila)
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PILRB paired immunoglobin-like type 2 receptor beta
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRF1 perforin 1 (pore forming protein)
PTK6 protein tyrosine kinase 6
RAB17 RAB17, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RHBDD3 rhomboid domain containing 3
RNF122 ring finger protein 122
SCGB2A2 secretoglobin, family 2A, member 2
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SETD8 SET domain containing (lysine methyltransferase) 8
SLITRK5 SLIT and NTRK-like family, member 5
SNIP1 Smad nuclear interacting protein 1
STAB2 stabilin 2
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SYNPO synaptopodin
TAGLN3 transgelin 3
TEP1 telomerase-associated protein 1
TINAGL1 tubulointerstitial nephritis antigen-like 1
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNS2 tensin 2
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
USB1 U6 snRNA biogenesis 1
WFDC2 WAP four-disulfide core domain 2
WNT7A wingless-type MMTV integration site family, member 7A
ZNF230 zinc finger protein 230
ZNF385D zinc finger protein 385D
ZNF76 zinc finger protein 76