Prestwick-664-4737 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the Prestwick-664-4737 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACOT11 acyl-CoA thioesterase 11
ADAM22 ADAM metallopeptidase domain 22
ADAM8 ADAM metallopeptidase domain 8
AJAP1 adherens junctions associated protein 1
ANGPT4 angiopoietin 4
ASCL1 achaete-scute family bHLH transcription factor 1
ATN1 atrophin 1
BAIAP3 BAI1-associated protein 3
BTF3P11 basic transcription factor 3 pseudogene 11
C10ORF95 chromosome 10 open reading frame 95
C7ORF69 chromosome 7 open reading frame 69
CCDC64 coiled-coil domain containing 64
CCNJL cyclin J-like
CCR7 chemokine (C-C motif) receptor 7
CD40LG CD40 ligand
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CLTA clathrin, light chain A
CPA2 carboxypeptidase A2 (pancreatic)
CPN2 carboxypeptidase N, polypeptide 2
CRYAB crystallin, alpha B
CSNK1G1 casein kinase 1, gamma 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DTX2 deltex 2, E3 ubiquitin ligase
ERCC2 excision repair cross-complementation group 2
F12 coagulation factor XII (Hageman factor)
FBLN1 fibulin 1
FGF8 fibroblast growth factor 8 (androgen-induced)
FRMD1 FERM domain containing 1
FZD5 frizzled class receptor 5
FZD9 frizzled class receptor 9
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GJA8 gap junction protein, alpha 8, 50kDa
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GREB1L growth regulation by estrogen in breast cancer-like
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HDAC7 histone deacetylase 7
HMGN5 high mobility group nucleosome binding domain 5
HOXC8 homeobox C8
HSF1 heat shock transcription factor 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGSF6 immunoglobulin superfamily, member 6
IL18 interleukin 18
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KIAA1109 KIAA1109
KLF1 Kruppel-like factor 1 (erythroid)
LAT2 linker for activation of T cells family, member 2
LEFTY2 left-right determination factor 2
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
MED25 mediator complex subunit 25
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MYCNOS MYCN opposite strand
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYOZ1 myozenin 1
MYT1L myelin transcription factor 1-like
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEUROD1 neuronal differentiation 1
NPFF neuropeptide FF-amide peptide precursor
OPCML opioid binding protein/cell adhesion molecule-like
OSGIN1 oxidative stress induced growth inhibitor 1
PCNXL2 pecanex-like 2 (Drosophila)
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFD platelet derived growth factor D
POM121L2 POM121 transmembrane nucleoporin-like 2
PPP1R37 protein phosphatase 1, regulatory subunit 37
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
RAB3B RAB3B, member RAS oncogene family
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RETN resistin
RIMS3 regulating synaptic membrane exocytosis 3
RSU1 Ras suppressor protein 1
SCAND2P SCAN domain containing 2 pseudogene
SERHL2 serine hydrolase-like 2
SETBP1 SET binding protein 1
SIPA1L3 signal-induced proliferation-associated 1 like 3
SORBS2 sorbin and SH3 domain containing 2
SPARCL1 SPARC-like 1 (hevin)
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
TBXA2R thromboxane A2 receptor
TCP11L1 t-complex 11, testis-specific-like 1
THAP9 THAP domain containing 9
THOC5 THO complex 5
TJAP1 tight junction associated protein 1 (peripheral)
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TOP3A topoisomerase (DNA) III alpha
TRIM3 tripartite motif containing 3
TSC2 tuberous sclerosis 2
TTLL4 tubulin tyrosine ligase-like family member 4
TUBB7P tubulin, beta 7, pseudogene
VAV2 vav 2 guanine nucleotide exchange factor
VCX2 variable charge, X-linked 2
ZFP64 ZFP64 zinc finger protein
ZNF112 zinc finger protein 112

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACTG2 actin, gamma 2, smooth muscle, enteric
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AKR1C3 aldo-keto reductase family 1, member C3
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
B9D2 B9 protein domain 2
C14ORF79 chromosome 14 open reading frame 79
C2ORF27A chromosome 2 open reading frame 27A
C6ORF47 chromosome 6 open reading frame 47
CCDC186 coiled-coil domain containing 186
CCRL2 chemokine (C-C motif) receptor-like 2
CENPO centromere protein O
CEP97 centrosomal protein 97kDa
CIDEC cell death-inducing DFFA-like effector c
CLCF1 cardiotrophin-like cytokine factor 1
CNGB3 cyclic nucleotide gated channel beta 3
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DNM3 dynamin 3
DPY19L1P1 DPY19L1 pseudogene 1
ECH1 enoyl CoA hydratase 1, peroxisomal
EFNA3 ephrin-A3
EGFL7 EGF-like-domain, multiple 7
ERCC6 excision repair cross-complementation group 6
ERN2 endoplasmic reticulum to nucleus signaling 2
ETNK2 ethanolamine kinase 2
FAM155A family with sequence similarity 155, member A
FGF23 fibroblast growth factor 23
FICD FIC domain containing
FKRP fukutin related protein
FLJ11710 uncharacterized protein FLJ11710
FOXC1 forkhead box C1
GAMT guanidinoacetate N-methyltransferase
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GJA9 gap junction protein, alpha 9, 59kDa
GPX2 glutathione peroxidase 2
HIST1H1D histone cluster 1, H1d
HMOX1 heme oxygenase 1
HPS6 Hermansky-Pudlak syndrome 6
INCENP inner centromere protein antigens 135/155kDa
KCTD17 potassium channel tetramerization domain containing 17
LAX1 lymphocyte transmembrane adaptor 1
LOC100287590 uncharacterized LOC100287590
LZTS3 leucine zipper, putative tumor suppressor family member 3
MBTPS2 membrane-bound transcription factor peptidase, site 2
MRPL44 mitochondrial ribosomal protein L44
MTCP1 mature T-cell proliferation 1
NARFL nuclear prelamin A recognition factor-like
NCALD neurocalcin delta
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEUROD4 neuronal differentiation 4
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PGR progesterone receptor
PMCH pro-melanin-concentrating hormone
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RFPL3 ret finger protein-like 3
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
ROM1 retinal outer segment membrane protein 1
RPA4 replication protein A4, 30kDa
RPL23AP32 ribosomal protein L23a pseudogene 32
RUNDC3B RUN domain containing 3B
SAMD9 sterile alpha motif domain containing 9
SAYSD1 SAYSVFN motif domain containing 1
SCG2 secretogranin II
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMR3A submaxillary gland androgen regulated protein 3A
SPATA2L spermatogenesis associated 2-like
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TFF2 trefoil factor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
THBS3 thrombospondin 3
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM53 transmembrane protein 53
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM36 tripartite motif containing 36
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSGA10 testis specific, 10
VASH1 vasohibin 1
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VIM vimentin
VIPR1 vasoactive intestinal peptide receptor 1
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZBTB22 zinc finger and BTB domain containing 22
ZBTB44 zinc finger and BTB domain containing 44
ZBTB6 zinc finger and BTB domain containing 6
ZNF141 zinc finger protein 141
ZNF204P zinc finger protein 204, pseudogene
ZNF205 zinc finger protein 205
ZNF34 zinc finger protein 34
ZNF37BP zinc finger protein 37B, pseudogene
ZNF442 zinc finger protein 442
ZNF480 zinc finger protein 480
ZNF711 zinc finger protein 711
ZSCAN26 zinc finger and SCAN domain containing 26