Prestwick-559-7462 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the Prestwick-559-7462 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ADAP1 ArfGAP with dual PH domains 1
AIM1L absent in melanoma 1-like
AIM2 absent in melanoma 2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
ARHGAP26 Rho GTPase activating protein 26
ARMC4 armadillo repeat containing 4
ATN1 atrophin 1
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BIN1 bridging integrator 1
CCDC25 coiled-coil domain containing 25
CCDC93 coiled-coil domain containing 93
CELA3A chymotrypsin-like elastase family, member 3A
CERS4 ceramide synthase 4
CFAP69 cilia and flagella associated protein 69
CHRM5 cholinergic receptor, muscarinic 5
CIC capicua transcriptional repressor
CYTH1 cytohesin 1
DAAM2 dishevelled associated activator of morphogenesis 2
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DMC1 DNA meiotic recombinase 1
DOPEY2 dopey family member 2
EGFL7 EGF-like-domain, multiple 7
ETV5 ets variant 5
FAM120C family with sequence similarity 120C
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FCMR Fc fragment of IgM receptor
FGL1 fibrinogen-like 1
FOXN3 forkhead box N3
GGT1 gamma-glutamyltransferase 1
GLS glutaminase
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
IFNA14 interferon, alpha 14
IFT27 intraflagellar transport 27
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
INSIG1 insulin induced gene 1
IQCK IQ motif containing K
JUN jun proto-oncogene
KIAA0355 KIAA0355
KLHL24 kelch-like family member 24
KSR1 kinase suppressor of ras 1
LIME1 Lck interacting transmembrane adaptor 1
LPIN1 lipin 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXD4 MAX dimerization protein 4
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
MYL5 myosin, light chain 5, regulatory
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PAX5 paired box 5
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDHA9 protocadherin alpha 9
PCM1 pericentriolar material 1
PHTF2 putative homeodomain transcription factor 2
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PRG3 proteoglycan 3
PSG11 pregnancy specific beta-1-glycoprotein 11
RAB30 RAB30, member RAS oncogene family
RECQL4 RecQ protein-like 4
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF126P1 ring finger protein 126 pseudogene 1
RNF39 ring finger protein 39
SH2B3 SH2B adaptor protein 3
SH3BP2 SH3-domain binding protein 2
SIRPA signal-regulatory protein alpha
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SNX13 sorting nexin 13
SOCS6 suppressor of cytokine signaling 6
SPN sialophorin
SPTBN1 spectrin, beta, non-erythrocytic 1
STAT5B signal transducer and activator of transcription 5B
TAZ tafazzin
TBXA2R thromboxane A2 receptor
TEC tec protein tyrosine kinase
TF transferrin
TGM2 transglutaminase 2
TP53I11 tumor protein p53 inducible protein 11
TTC9 tetratricopeptide repeat domain 9
TTLL5 tubulin tyrosine ligase-like family member 5
USP34 ubiquitin specific peptidase 34
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VEGFB vascular endothelial growth factor B
VPS9D1 VPS9 domain containing 1
WDTC1 WD and tetratricopeptide repeats 1
ZBTB14 zinc finger and BTB domain containing 14
ZHX3 zinc fingers and homeoboxes 3
ZNF350 zinc finger protein 350
ZNF41 zinc finger protein 41
ZNF500 zinc finger protein 500
ZNF695 zinc finger protein 695

decreased expression

Symbol Name
AARSD1 alanyl-tRNA synthetase domain containing 1
AEN apoptosis enhancing nuclease
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ATAD3A ATPase family, AAA domain containing 3A
AZI2 5-azacytidine induced 2
BCL9 B-cell CLL/lymphoma 9
BRIX1 BRX1, biogenesis of ribosomes
C11ORF30 chromosome 11 open reading frame 30
C7ORF43 chromosome 7 open reading frame 43
CARD8 caspase recruitment domain family, member 8
CCNO cyclin O
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CENPT centromere protein T
CEP85 centrosomal protein 85kDa
CHEK2 checkpoint kinase 2
CHMP6 charged multivesicular body protein 6
CISH cytokine inducible SH2-containing protein
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CLSPN claspin
DDIT3 DNA-damage-inducible transcript 3
DMXL1 Dmx-like 1
DSN1 DSN1, MIS12 kinetochore complex component
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERCC4 excision repair cross-complementation group 4
ERI3 ERI1 exoribonuclease family member 3
FAM118A family with sequence similarity 118, member A
FKBP5 FK506 binding protein 5
GAB2 GRB2-associated binding protein 2
GCHFR GTP cyclohydrolase I feedback regulator
GLB1L2 galactosidase, beta 1-like 2
GPATCH3 G patch domain containing 3
GTPBP2 GTP binding protein 2
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HAUS6 HAUS augmin-like complex, subunit 6
HDAC4 histone deacetylase 4
HECA headcase homolog (Drosophila)
HIST1H2AM histone cluster 1, H2am
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IRF7 interferon regulatory factor 7
ITPKC inositol-trisphosphate 3-kinase C
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCTD15 potassium channel tetramerization domain containing 15
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIMA1 LIM domain and actin binding 1
LRP3 low density lipoprotein receptor-related protein 3
LYPD1 LY6/PLAUR domain containing 1
MAD2L1BP MAD2L1 binding protein
MAGOHB mago-nashi homolog B (Drosophila)
MEIS1 Meis homeobox 1
METTL2B methyltransferase like 2B
MITF microphthalmia-associated transcription factor
MORC3 MORC family CW-type zinc finger 3
MTRF1 mitochondrial translational release factor 1
MXD3 MAX dimerization protein 3
NCS1 neuronal calcium sensor 1
NHLRC2 NHL repeat containing 2
NT5DC3 5'-nucleotidase domain containing 3
NUPL1 nucleoporin like 1
NUPL2 nucleoporin like 2
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
OSMR oncostatin M receptor
OXTR oxytocin receptor
PADI2 peptidyl arginine deiminase, type II
PAQR3 progestin and adipoQ receptor family member III
PARD6A par-6 family cell polarity regulator alpha
PCNXL4 pecanex-like 4 (Drosophila)
PDZRN3 PDZ domain containing ring finger 3
PLA2G12A phospholipase A2, group XIIA
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
RBL1 retinoblastoma-like 1
RCOR3 REST corepressor 3
RPAP1 RNA polymerase II associated protein 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SETD8 SET domain containing (lysine methyltransferase) 8
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNORA21 small nucleolar RNA, H/ACA box 21
STBD1 starch binding domain 1
TMEM165 transmembrane protein 165
TPTE transmembrane phosphatase with tensin homology
TRIM25 tripartite motif containing 25
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTC23 tetratricopeptide repeat domain 23
TTC33 tetratricopeptide repeat domain 33
TTC4 tetratricopeptide repeat domain 4
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VWA1 von Willebrand factor A domain containing 1
ZC3H3 zinc finger CCCH-type containing 3
ZDHHC18 zinc finger, DHHC-type containing 18
ZNF226 zinc finger protein 226
ZNF32 zinc finger protein 32
ZNF586 zinc finger protein 586
ZNF623 zinc finger protein 623
ZNF787 zinc finger protein 787
ZXDC ZXD family zinc finger C