Prestwick-1103-2978 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the Prestwick-1103-2978 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT11 acyl-CoA thioesterase 11
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALPPL2 alkaline phosphatase, placental-like 2
ANKRD26 ankyrin repeat domain 26
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARMC9 armadillo repeat containing 9
ASPN asporin
ATP11A ATPase, class VI, type 11A
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BCR breakpoint cluster region
C17ORF53 chromosome 17 open reading frame 53
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCDC9 coiled-coil domain containing 9
CCSER2 coiled-coil serine-rich protein 2
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLIP2 CAP-GLY domain containing linker protein 2
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COL11A2 collagen, type XI, alpha 2
CPB1 carboxypeptidase B1 (tissue)
CRYGC crystallin, gamma C
CXCL6 chemokine (C-X-C motif) ligand 6
CYLD cylindromatosis (turban tumor syndrome)
DCAF15 DDB1 and CUL4 associated factor 15
DSTYK dual serine/threonine and tyrosine protein kinase
E2F4 E2F transcription factor 4, p107/p130-binding
EXD3 exonuclease 3'-5' domain containing 3
FOSL2 FOS-like antigen 2
FRS2 fibroblast growth factor receptor substrate 2
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GPR153 G protein-coupled receptor 153
GSDMB gasdermin B
GSK3A glycogen synthase kinase 3 alpha
GSTA3 glutathione S-transferase alpha 3
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HEG1 heart development protein with EGF-like domains 1
HIST1H3G histone cluster 1, H3g
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HYAL2 hyaluronoglucosaminidase 2
KCTD2 potassium channel tetramerization domain containing 2
KLHL20 kelch-like family member 20
LDHC lactate dehydrogenase C
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAGEA5 melanoma antigen family A5
MIR22HG MIR22 host gene
MKL1 megakaryoblastic leukemia (translocation) 1
MYBPH myosin binding protein H
MYH15 myosin, heavy chain 15
NEURL1 neuralized E3 ubiquitin protein ligase 1
NOL10 nucleolar protein 10
NUMA1 nuclear mitotic apparatus protein 1
NUP88 nucleoporin 88kDa
PADI2 peptidyl arginine deiminase, type II
PARP12 poly (ADP-ribose) polymerase family, member 12
PBX2 pre-B-cell leukemia homeobox 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFRL platelet-derived growth factor receptor-like
PDLIM2 PDZ and LIM domain 2 (mystique)
PEX10 peroxisomal biogenesis factor 10
PGAM2 phosphoglycerate mutase 2 (muscle)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAGL2 pleiomorphic adenoma gene-like 2
PPT2 palmitoyl-protein thioesterase 2
PTAFR platelet-activating factor receptor
PTCRA pre T-cell antigen receptor alpha
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PYGB phosphorylase, glycogen; brain
RAB6A RAB6A, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RGS14 regulator of G-protein signaling 14
RGS19 regulator of G-protein signaling 19
RPL13P5 ribosomal protein L13 pseudogene 5
RRBP1 ribosome binding protein 1
RUNX1 runt-related transcription factor 1
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC16A4 solute carrier family 16, member 4
SLC22A14 solute carrier family 22, member 14
SMYD2 SET and MYND domain containing 2
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STAT5B signal transducer and activator of transcription 5B
SURF1 surfeit 1
SYNM synemin, intermediate filament protein
TICAM1 toll-like receptor adaptor molecule 1
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TLN2 talin 2
TMEM184C transmembrane protein 184C
TTLL3 tubulin tyrosine ligase-like family member 3
TXN thioredoxin
UBR4 ubiquitin protein ligase E3 component n-recognin 4
VASP vasodilator-stimulated phosphoprotein
WDR62 WD repeat domain 62
WWC1 WW and C2 domain containing 1
XAB2 XPA binding protein 2
ZDHHC14 zinc finger, DHHC-type containing 14
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF606 zinc finger protein 606

decreased expression

Symbol Name
ADORA3 adenosine A3 receptor
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BHLHE41 basic helix-loop-helix family, member e41
BNC2 basonuclin 2
BTBD2 BTB (POZ) domain containing 2
C22ORF46 chromosome 22 open reading frame 46
CA5BP1 carbonic anhydrase VB pseudogene 1
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CES3 carboxylesterase 3
CLEC2D C-type lectin domain family 2, member D
COL15A1 collagen, type XV, alpha 1
COL9A2 collagen, type IX, alpha 2
CORO7 coronin 7
CRY2 cryptochrome circadian clock 2
DEPDC5 DEP domain containing 5
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNASE1L1 deoxyribonuclease I-like 1
EDC4 enhancer of mRNA decapping 4
EGR2 early growth response 2
FBXL7 F-box and leucine-rich repeat protein 7
FHL3 four and a half LIM domains 3
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GID4 GID complex subunit 4
HIST1H2AJ histone cluster 1, H2aj
HIST1H4D histone cluster 1, H4d
IDI2-AS1 IDI2 antisense RNA 1
IFI30 interferon, gamma-inducible protein 30
IFNA14 interferon, alpha 14
IFT81 intraflagellar transport 81
IL11RA interleukin 11 receptor, alpha
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KLF2 Kruppel-like factor 2
KLHL26 kelch-like family member 26
LAX1 lymphocyte transmembrane adaptor 1
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LYPLA2P1 lysophospholipase II pseudogene 1
LZTR1 leucine-zipper-like transcription regulator 1
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MLYCD malonyl-CoA decarboxylase
MX1 MX dynamin-like GTPase 1
MYBBP1A MYB binding protein (P160) 1a
NDE1 nudE neurodevelopment protein 1
NKX3-2 NK3 homeobox 2
NOL6 nucleolar protein 6 (RNA-associated)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PECR peroxisomal trans-2-enoyl-CoA reductase
PGPEP1 pyroglutamyl-peptidase I
PHC1 polyhomeotic homolog 1 (Drosophila)
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLS1 plastin 1
PMP22 peripheral myelin protein 22
POMT1 protein-O-mannosyltransferase 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R3C protein phosphatase 1, regulatory subunit 3C
QSER1 glutamine and serine rich 1
RBKS ribokinase
RETN resistin
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RHOB ras homolog family member B
SCAMP5 secretory carrier membrane protein 5
SHPK sedoheptulokinase
SIGLEC15 sialic acid binding Ig-like lectin 15
SKI SKI proto-oncogene
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
ST7L suppression of tumorigenicity 7 like
STON1 stonin 1
STRN striatin, calmodulin binding protein
SURF2 surfeit 2
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TESK1 testis-specific kinase 1
TGM5 transglutaminase 5
THEM6 thioesterase superfamily member 6
TLR8 toll-like receptor 8
TMEM242 transmembrane protein 242
TRAF1 TNF receptor-associated factor 1
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UBE2O ubiquitin-conjugating enzyme E2O
UNKL unkempt family zinc finger-like
YY2 YY2 transcription factor
ZC3H3 zinc finger CCCH-type containing 3
ZHX2 zinc fingers and homeoboxes 2
ZNF215 zinc finger protein 215
ZNF32 zinc finger protein 32
ZNF37BP zinc finger protein 37B, pseudogene
ZNF76 zinc finger protein 76
ZSCAN5A zinc finger and SCAN domain containing 5A