Prestwick-1100-4534 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the Prestwick-1100-4534 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP8L A kinase (PRKA) anchor protein 8-like
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
ALDOB aldolase B, fructose-bisphosphate
AMT aminomethyltransferase
ANGPTL4 angiopoietin-like 4
ASIC3 acid sensing (proton gated) ion channel 3
BAGE B melanoma antigen
BAIAP3 BAI1-associated protein 3
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCAS1 breast carcinoma amplified sequence 1
C14ORF79 chromosome 14 open reading frame 79
C17ORF53 chromosome 17 open reading frame 53
C22ORF46 chromosome 22 open reading frame 46
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCDC102B coiled-coil domain containing 102B
CD72 CD72 molecule
CD86 CD86 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CERS4 ceramide synthase 4
CLCA1 chloride channel accessory 1
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COL15A1 collagen, type XV, alpha 1
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
DMBT1 deleted in malignant brain tumors 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DSTYK dual serine/threonine and tyrosine protein kinase
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ELL elongation factor RNA polymerase II
ERAP1 endoplasmic reticulum aminopeptidase 1
ETV1 ets variant 1
F2RL2 coagulation factor II (thrombin) receptor-like 2
FBXO31 F-box protein 31
FGF5 fibroblast growth factor 5
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GK glycerol kinase
GK3P glycerol kinase 3 pseudogene
GMPR guanosine monophosphate reductase
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HDAC11 histone deacetylase 11
HIST1H3F histone cluster 1, H3f
HOXB2 homeobox B2
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
ITPK1 inositol-tetrakisphosphate 1-kinase
IVL involucrin
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIAA1467 KIAA1467
KIF25-AS1 KIF25 antisense RNA 1
KIF5C kinesin family member 5C
KRT34 keratin 34, type I
LIG4 ligase IV, DNA, ATP-dependent
LINC00115 long intergenic non-protein coding RNA 115
LINC00652 long intergenic non-protein coding RNA 652
LMX1B LIM homeobox transcription factor 1, beta
MAL mal, T-cell differentiation protein
MCOLN3 mucolipin 3
MMP11 matrix metallopeptidase 11
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MRAS muscle RAS oncogene homolog
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
NACAD NAC alpha domain containing
NEB nebulin
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRP2 neuropilin 2
PAWR PRKC, apoptosis, WT1, regulator
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PLCH1 phospholipase C, eta 1
POU4F2 POU class 4 homeobox 2
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAD51 RAD51 recombinase
RBM12B RNA binding motif protein 12B
RBMS2 RNA binding motif, single stranded interacting protein 2
RNGTT RNA guanylyltransferase and 5'-phosphatase
SCYL2 SCY1-like 2 (S. cerevisiae)
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
ST7L suppression of tumorigenicity 7 like
STS steroid sulfatase (microsomal), isozyme S
TBXA2R thromboxane A2 receptor
TOP3A topoisomerase (DNA) III alpha
TTC12 tetratricopeptide repeat domain 12
USP29 ubiquitin specific peptidase 29
UST uronyl-2-sulfotransferase
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZMIZ2 zinc finger, MIZ-type containing 2

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
AFAP1 actin filament associated protein 1
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APOL6 apolipoprotein L, 6
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATAT1 alpha tubulin acetyltransferase 1
ATP7B ATPase, Cu++ transporting, beta polypeptide
BAAT bile acid CoA:amino acid N-acyltransferase
BCL9 B-cell CLL/lymphoma 9
C11ORF30 chromosome 11 open reading frame 30
C1ORF159 chromosome 1 open reading frame 159
C5ORF45 chromosome 5 open reading frame 45
C8ORF60 chromosome 8 open reading frame 60
CA5BP1 carbonic anhydrase VB pseudogene 1
CAMTA2 calmodulin binding transcription activator 2
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CD68 CD68 molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CENPJ centromere protein J
CHD3 chromodomain helicase DNA binding protein 3
CLSPN claspin
CNTNAP3B contactin associated protein-like 3B
CPED1 cadherin-like and PC-esterase domain containing 1
CPNE7 copine VII
CUL9 cullin 9
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DDN dendrin
EFTUD1 elongation factor Tu GTP binding domain containing 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERAP2 endoplasmic reticulum aminopeptidase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM186A family with sequence similarity 186, member A
FANCC Fanconi anemia, complementation group C
FOXN2 forkhead box N2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLS2 glutaminase 2 (liver, mitochondrial)
GRAMD4 GRAM domain containing 4
HDAC5 histone deacetylase 5
HELZ helicase with zinc finger
HIST1H2AJ histone cluster 1, H2aj
HIST1H3A histone cluster 1, H3a
HLX H2.0-like homeobox
HMHA1 histocompatibility (minor) HA-1
IFI35 interferon-induced protein 35
IQSEC2 IQ motif and Sec7 domain 2
KCTD15 potassium channel tetramerization domain containing 15
LMNB2 lamin B2
LOC390998 ribosomal protein L10 pseudogene
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAN2C1 mannosidase, alpha, class 2C, member 1
MBTD1 mbt domain containing 1
MGP matrix Gla protein
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MXRA8 matrix-remodelling associated 8
MYH15 myosin, heavy chain 15
NABP2 nucleic acid binding protein 2
NOL6 nucleolar protein 6 (RNA-associated)
NT5M 5',3'-nucleotidase, mitochondrial
OSBP2 oxysterol binding protein 2
OVGP1 oviductal glycoprotein 1, 120kDa
PACS1 phosphofurin acidic cluster sorting protein 1
PAIP2B poly(A) binding protein interacting protein 2B
PDE12 phosphodiesterase 12
PER3 period circadian clock 3
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLD2 phospholipase D2
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PNPLA6 patatin-like phospholipase domain containing 6
POM121 POM121 transmembrane nucleoporin
PRKX protein kinase, X-linked
PTPRE protein tyrosine phosphatase, receptor type, E
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIN1 Ras and Rab interactor 1
RNF122 ring finger protein 122
RUNDC3B RUN domain containing 3B
SCGB2A2 secretoglobin, family 2A, member 2
SDC3 syndecan 3
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SIRT6 sirtuin 6
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STARD3 StAR-related lipid transfer (START) domain containing 3
TBC1D17 TBC1 domain family, member 17
TBXAS1 thromboxane A synthase 1 (platelet)
TGFBI transforming growth factor, beta-induced, 68kDa
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRAPPC13 trafficking protein particle complex 13
WDR13 WD repeat domain 13
WNT10B wingless-type MMTV integration site family, member 10B
ZFAND3 zinc finger, AN1-type domain 3
ZNF137P zinc finger protein 137, pseudogene
ZNF215 zinc finger protein 215
ZNF747 zinc finger protein 747
ZNHIT2 zinc finger, HIT-type containing 2