Prestwick-1100-4356 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the Prestwick-1100-4356 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACRV1 acrosomal vesicle protein 1
ADAM12 ADAM metallopeptidase domain 12
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
ADGRL3 adhesion G protein-coupled receptor L3
AFF1 AF4/FMR2 family, member 1
ALOXE3 arachidonate lipoxygenase 3
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APAF1 apoptotic peptidase activating factor 1
BAIAP2 BAI1-associated protein 2
BARX2 BARX homeobox 2
BDKRB1 bradykinin receptor B1
BICC1 BicC family RNA binding protein 1
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
COL14A1 collagen, type XIV, alpha 1
CTNS cystinosin, lysosomal cystine transporter
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DIO2 deiodinase, iodothyronine, type II
DOK4 docking protein 4
E2F2 E2F transcription factor 2
EDNRA endothelin receptor type A
FBXL7 F-box and leucine-rich repeat protein 7
FOSL2 FOS-like antigen 2
FRMD1 FERM domain containing 1
FZD9 frizzled class receptor 9
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GFAP glial fibrillary acidic protein
GJA8 gap junction protein, alpha 8, 50kDa
GK glycerol kinase
GYPB glycophorin B (MNS blood group)
HOXB6 homeobox B6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSF4 heat shock transcription factor 4
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HYAL1 hyaluronoglucosaminidase 1
ICOS inducible T-cell co-stimulator
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGKV3-20 immunoglobulin kappa variable 3-20
IL11 interleukin 11
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITGB7 integrin, beta 7
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KIF21B kinesin family member 21B
KLF13 Kruppel-like factor 13
LAMC3 laminin, gamma 3
LAT2 linker for activation of T cells family, member 2
LCT lactase
LIMK1 LIM domain kinase 1
LINC00574 long intergenic non-protein coding RNA 574
MBD2 methyl-CpG binding domain protein 2
MLXIPL MLX interacting protein-like
MORN1 MORN repeat containing 1
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC3B mucin 3B, cell surface associated
MXD4 MAX dimerization protein 4
NOD2 nucleotide-binding oligomerization domain containing 2
NOVA2 neuro-oncological ventral antigen 2
NPHP1 nephronophthisis 1 (juvenile)
NPY neuropeptide Y
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NXPE3 neurexophilin and PC-esterase domain family, member 3
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
PER1 period circadian clock 1
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLCD1 phospholipase C, delta 1
PLTP phospholipid transfer protein
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PTPRM protein tyrosine phosphatase, receptor type, M
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RIF1 replication timing regulatory factor 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTEL1 regulator of telomere elongation helicase 1
RUNX1 runt-related transcription factor 1
S100A7 S100 calcium binding protein A7
SAG S-antigen; retina and pineal gland (arrestin)
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SERHL2 serine hydrolase-like 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC7A4 solute carrier family 7, member 4
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SOX15 SRY (sex determining region Y)-box 15
TBX3 T-box 3
THRB thyroid hormone receptor, beta
TLDC1 TBC/LysM-associated domain containing 1
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TP63 tumor protein p63
TRIM10 tripartite motif containing 10
TRIM36 tripartite motif containing 36
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF415 zinc finger protein 415

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACTG2 actin, gamma 2, smooth muscle, enteric
APLP1 amyloid beta (A4) precursor-like protein 1
ARMC4 armadillo repeat containing 4
ASIC3 acid sensing (proton gated) ion channel 3
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
C11ORF21 chromosome 11 open reading frame 21
C14ORF79 chromosome 14 open reading frame 79
C1ORF54 chromosome 1 open reading frame 54
C8ORF44 chromosome 8 open reading frame 44
C9ORF9 chromosome 9 open reading frame 9
CA5BP1 carbonic anhydrase VB pseudogene 1
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CASC1 cancer susceptibility candidate 1
CD82 CD82 molecule
CD83 CD83 molecule
CDH18 cadherin 18, type 2
CDK3 cyclin-dependent kinase 3
CDKN2AIP CDKN2A interacting protein
CEP85 centrosomal protein 85kDa
CLCN6 chloride channel, voltage-sensitive 6
CLIP4 CAP-GLY domain containing linker protein family, member 4
CPNE7 copine VII
CTAGE9 CTAGE family, member 9
DBF4B DBF4 zinc finger B
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DEPDC5 DEP domain containing 5
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
ELSPBP1 epididymal sperm binding protein 1
ETV6 ets variant 6
FBXL8 F-box and leucine-rich repeat protein 8
FSHB follicle stimulating hormone, beta polypeptide
GAMT guanidinoacetate N-methyltransferase
GPR143 G protein-coupled receptor 143
GPR27 G protein-coupled receptor 27
GSTP1 glutathione S-transferase pi 1
HDAC11 histone deacetylase 11
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HOXA4 homeobox A4
HOXC10 homeobox C10
IFI27 interferon, alpha-inducible protein 27
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIAA0754 KIAA0754
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LOC390998 ribosomal protein L10 pseudogene
LRRC37A3 leucine rich repeat containing 37, member A3
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MBNL3 muscleblind-like splicing regulator 3
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MYO1F myosin IF
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPY1R neuropeptide Y receptor Y1
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
PADI3 peptidyl arginine deiminase, type III
PAIP2B poly(A) binding protein interacting protein 2B
PARP3 poly (ADP-ribose) polymerase family, member 3
PCDHA9 protocadherin alpha 9
PCDHB3 protocadherin beta 3
PICK1 protein interacting with PRKCA 1
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POMT2 protein-O-mannosyltransferase 2
RAB33B RAB33B, member RAS oncogene family
RNF208 ring finger protein 208
SAYSD1 SAYSVFN motif domain containing 1
SCARA3 scavenger receptor class A, member 3
SCN1B sodium channel, voltage gated, type I beta subunit
SH2D4A SH2 domain containing 4A
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SNTA1 syntrophin, alpha 1
SOAT2 sterol O-acyltransferase 2
SP1 Sp1 transcription factor
SPINK5 serine peptidase inhibitor, Kazal type 5
ST5 suppression of tumorigenicity 5
TBC1D19 TBC1 domain family, member 19
TBC1D2 TBC1 domain family, member 2
TDRD1 tudor domain containing 1
TESC tescalcin
TEX40 testis expressed 40
TM4SF5 transmembrane 4 L six family member 5
TOR4A torsin family 4, member A
TTC30A tetratricopeptide repeat domain 30A
TUBA4B tubulin, alpha 4b
VPS9D1 VPS9 domain containing 1
XAB2 XPA binding protein 2
ZBTB44 zinc finger and BTB domain containing 44
ZNF205 zinc finger protein 205
ZNF286A zinc finger protein 286A
ZNF350 zinc finger protein 350
ZNF37BP zinc finger protein 37B, pseudogene
ZNF41 zinc finger protein 41
ZNF506 zinc finger protein 506
ZNF639 zinc finger protein 639