Prestwick-1084-7125 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the Prestwick-1084-7125 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
ADAP1 ArfGAP with dual PH domains 1
ADGRL1 adhesion G protein-coupled receptor L1
AKAP17A A kinase (PRKA) anchor protein 17A
ARHGAP24 Rho GTPase activating protein 24
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ATAD5 ATPase family, AAA domain containing 5
ATP9A ATPase, class II, type 9A
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BTN3A3 butyrophilin, subfamily 3, member A3
C15ORF39 chromosome 15 open reading frame 39
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CHD3 chromodomain helicase DNA binding protein 3
CLCN6 chloride channel, voltage-sensitive 6
CREB3L1 cAMP responsive element binding protein 3-like 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DDN dendrin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DSTYK dual serine/threonine and tyrosine protein kinase
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GAB2 GRB2-associated binding protein 2
GMIP GEM interacting protein
GNA14 guanine nucleotide binding protein (G protein), alpha 14
H2AFX H2A histone family, member X
HIST1H1D histone cluster 1, H1d
HOMER2 homer scaffolding protein 2
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IFNA14 interferon, alpha 14
IL4R interleukin 4 receptor
INF2 inverted formin, FH2 and WH2 domain containing
IRS2 insulin receptor substrate 2
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KIF3C kinesin family member 3C
KIF5C kinesin family member 5C
KLHL20 kelch-like family member 20
KYNU kynureninase
LGALS8 lectin, galactoside-binding, soluble, 8
LIMS2 LIM and senescent cell antigen-like domains 2
LMO4 LIM domain only 4
LRRC61 leucine rich repeat containing 61
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MAPK14 mitogen-activated protein kinase 14
MAPK7 mitogen-activated protein kinase 7
MAPT microtubule-associated protein tau
MARK4 MAP/microtubule affinity-regulating kinase 4
MAST4 microtubule associated serine/threonine kinase family member 4
MED25 mediator complex subunit 25
METTL22 methyltransferase like 22
MFSD11 major facilitator superfamily domain containing 11
MSL3 male-specific lethal 3 homolog (Drosophila)
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NAGLU N-acetylglucosaminidase, alpha
NCAM1 neural cell adhesion molecule 1
NOL10 nucleolar protein 10
OPTN optineurin
OXLD1 oxidoreductase-like domain containing 1
PEX6 peroxisomal biogenesis factor 6
PNPLA4 patatin-like phospholipase domain containing 4
POMT2 protein-O-mannosyltransferase 2
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRRC2B proline-rich coiled-coil 2B
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RERE arginine-glutamic acid dipeptide (RE) repeats
RGS10 regulator of G-protein signaling 10
RHOBTB2 Rho-related BTB domain containing 2
RIBC2 RIB43A domain with coiled-coils 2
RTEL1 regulator of telomere elongation helicase 1
SCARA3 scavenger receptor class A, member 3
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SHROOM2 shroom family member 2
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SUGP1 SURP and G patch domain containing 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SUN1 Sad1 and UNC84 domain containing 1
TAPT1 transmembrane anterior posterior transformation 1
TAT tyrosine aminotransferase
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TCP10L t-complex 10-like
TH tyrosine hydroxylase
TIGD6 tigger transposable element derived 6
TJAP1 tight junction associated protein 1 (peripheral)
TMEM80 transmembrane protein 80
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UBOX5 U-box domain containing 5
USP18 ubiquitin specific peptidase 18
ZNF500 zinc finger protein 500
ZNF749 zinc finger protein 749
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
AATF apoptosis antagonizing transcription factor
ADAM15 ADAM metallopeptidase domain 15
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANXA10 annexin A10
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
BCAS4 breast carcinoma amplified sequence 4
BCL7C B-cell CLL/lymphoma 7C
BGLAP bone gamma-carboxyglutamate (gla) protein
BLMH bleomycin hydrolase
C3ORF52 chromosome 3 open reading frame 52
CBX7 chromobox homolog 7
CEP85 centrosomal protein 85kDa
CHD8 chromodomain helicase DNA binding protein 8
CHM choroideremia (Rab escort protein 1)
CHST10 carbohydrate sulfotransferase 10
CINP cyclin-dependent kinase 2 interacting protein
CLEC2B C-type lectin domain family 2, member B
COCH cochlin
CPVL carboxypeptidase, vitellogenic-like
CRIP1 cysteine-rich protein 1 (intestinal)
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNMBP dynamin binding protein
DPY19L2P2 DPY19L2 pseudogene 2
EAF2 ELL associated factor 2
EDC3 enhancer of mRNA decapping 3
EIF5A2 eukaryotic translation initiation factor 5A2
F8 coagulation factor VIII, procoagulant component
FAM127B family with sequence similarity 127, member B
FGD1 FYVE, RhoGEF and PH domain containing 1
FPGS folylpolyglutamate synthase
GDAP1 ganglioside induced differentiation associated protein 1
GID4 GID complex subunit 4
GLCE glucuronic acid epimerase
HEATR3 HEAT repeat containing 3
HYI hydroxypyruvate isomerase (putative)
IL7R interleukin 7 receptor
IRF6 interferon regulatory factor 6
KCTD15 potassium channel tetramerization domain containing 15
KCTD7 potassium channel tetramerization domain containing 7
KIAA1462 KIAA1462
KLHL2 kelch-like family member 2
MAGEA6 melanoma antigen family A6
MAVS mitochondrial antiviral signaling protein
MECR mitochondrial trans-2-enoyl-CoA reductase
MED23 mediator complex subunit 23
METRN meteorin, glial cell differentiation regulator
MIR22HG MIR22 host gene
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MTRF1 mitochondrial translational release factor 1
NABP2 nucleic acid binding protein 2
NPM3 nucleophosmin/nucleoplasmin 3
OGFRL1 opioid growth factor receptor-like 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PARD6A par-6 family cell polarity regulator alpha
PID1 phosphotyrosine interaction domain containing 1
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PROS1 protein S (alpha)
PRPF38B pre-mRNA processing factor 38B
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAP1GAP2 RAP1 GTPase activating protein 2
RBL1 retinoblastoma-like 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SDHAF1 succinate dehydrogenase complex assembly factor 1
SIX1 SIX homeobox 1
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLMO2 slowmo homolog 2 (Drosophila)
SMA4 glucuronidase, beta pseudogene
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
TAGLN3 transgelin 3
TEAD3 TEA domain family member 3
TGIF1 TGFB-induced factor homeobox 1
THAP4 THAP domain containing 4
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TM7SF2 transmembrane 7 superfamily member 2
TM7SF3 transmembrane 7 superfamily member 3
TMEM8A transmembrane protein 8A
TMOD3 tropomodulin 3 (ubiquitous)
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TOR3A torsin family 3, member A
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
UBTD1 ubiquitin domain containing 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
USPL1 ubiquitin specific peptidase like 1
VASH2 vasohibin 2
WDR13 WD repeat domain 13
ZNF385D zinc finger protein 385D
ZNF552 zinc finger protein 552
ZNF816 zinc finger protein 816
ZSCAN16 zinc finger and SCAN domain containing 16
ZSCAN26 zinc finger and SCAN domain containing 26