Prestwick-1084-6767 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the Prestwick-1084-6767 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDOB aldolase B, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
AMT aminomethyltransferase
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ASCL1 achaete-scute family bHLH transcription factor 1
BAIAP3 BAI1-associated protein 3
BMP1 bone morphogenetic protein 1
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C1QTNF1 C1q and tumor necrosis factor related protein 1
C21ORF2 chromosome 21 open reading frame 2
C3 complement component 3
CCDC64 coiled-coil domain containing 64
CCKAR cholecystokinin A receptor
CDH17 cadherin 17, LI cadherin (liver-intestine)
CLDN11 claudin 11
CLIC2 chloride intracellular channel 2
CLPS colipase, pancreatic
COL11A2 collagen, type XI, alpha 2
CYTH1 cytohesin 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DPF1 D4, zinc and double PHD fingers family 1
DUSP13 dual specificity phosphatase 13
EFHC2 EF-hand domain (C-terminal) containing 2
ETNK2 ethanolamine kinase 2
FAM212B family with sequence similarity 212, member B
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FCAR Fc fragment of IgA receptor
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGF18 fibroblast growth factor 18
FGF6 fibroblast growth factor 6
FHL1 four and a half LIM domains 1
FRMD4B FERM domain containing 4B
GHRHR growth hormone releasing hormone receptor
GLIPR1 GLI pathogenesis-related 1
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble)
GRB10 growth factor receptor-bound protein 10
GSAP gamma-secretase activating protein
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HCAR3 hydroxycarboxylic acid receptor 3
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL11 interleukin 11
IL12RB1 interleukin 12 receptor, beta 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB4 integrin, beta 4
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KRI1 KRI1 homolog (S. cerevisiae)
LOC399491
LPAR4 lysophosphatidic acid receptor 4
MID1 midline 1
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
NECAB2 N-terminal EF-hand calcium binding protein 2
NME5 NME/NM23 family member 5
NPAS3 neuronal PAS domain protein 3
OPRK1 opioid receptor, kappa 1
OSBPL10 oxysterol binding protein-like 10
PARP3 poly (ADP-ribose) polymerase family, member 3
PDE4A phosphodiesterase 4A, cAMP-specific
PPARD peroxisome proliferator-activated receptor delta
PQLC2 PQ loop repeat containing 2
PTCRA pre T-cell antigen receptor alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB40C RAB40C, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RFPL3 ret finger protein-like 3
RREB1 ras responsive element binding protein 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFRP4 secreted frizzled-related protein 4
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SLN sarcolipin
SMG7-AS1 SMG7 antisense RNA 1
SNPH syntaphilin
SPAG8 sperm associated antigen 8
SRSF7 serine/arginine-rich splicing factor 7
SSBP1 single-stranded DNA binding protein 1, mitochondrial
SYN2 synapsin II
TAT tyrosine aminotransferase
TBC1D29 TBC1 domain family, member 29
TFDP3 transcription factor Dp family, member 3
TGM4 transglutaminase 4
TIMP3 TIMP metallopeptidase inhibitor 3
TJAP1 tight junction associated protein 1 (peripheral)
TJP3 tight junction protein 3
TMEM120B transmembrane protein 120B
TTC38 tetratricopeptide repeat domain 38
UBOX5 U-box domain containing 5
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
WFDC2 WAP four-disulfide core domain 2
WNT6 wingless-type MMTV integration site family, member 6
ZNF204P zinc finger protein 204, pseudogene
ZNF41 zinc finger protein 41
ZNF639 zinc finger protein 639
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ANXA2P3 annexin A2 pseudogene 3
APOLD1 apolipoprotein L domain containing 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ASAP1-IT1 ASAP1 intronic transcript 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
C11ORF49 chromosome 11 open reading frame 49
C14ORF93 chromosome 14 open reading frame 93
C7ORF43 chromosome 7 open reading frame 43
CCNL2 cyclin L2
CD302 CD302 molecule
CDK3 cyclin-dependent kinase 3
CHML choroideremia-like (Rab escort protein 2)
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CIC capicua transcriptional repressor
CIDEC cell death-inducing DFFA-like effector c
CLDN1 claudin 1
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CRABP1 cellular retinoic acid binding protein 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRY2 cryptochrome circadian clock 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
ELAVL3 ELAV like neuron-specific RNA binding protein 3
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAAH fatty acid amide hydrolase
FAM118A family with sequence similarity 118, member A
FAM184A family with sequence similarity 184, member A
FBXW12 F-box and WD repeat domain containing 12
FMO4 flavin containing monooxygenase 4
FRS2 fibroblast growth factor receptor substrate 2
GPR27 G protein-coupled receptor 27
GPX2 glutathione peroxidase 2
GRB7 growth factor receptor-bound protein 7
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HIST2H2AA3 histone cluster 2, H2aa3
IFI6 interferon, alpha-inducible protein 6
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KIAA0125 KIAA0125
KIAA0319L KIAA0319-like
LMBR1L limb development membrane protein 1-like
LOC730101 uncharacterized LOC730101
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MYO1E myosin IE
NIPAL2 NIPA-like domain containing 2
NT5E 5'-nucleotidase, ecto (CD73)
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEKHA6 pleckstrin homology domain containing, family A member 6
RAD54L2 RAD54-like 2 (S. cerevisiae)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS17 regulator of G-protein signaling 17
RGS2 regulator of G-protein signaling 2
RIBC2 RIB43A domain with coiled-coils 2
RPL13P5 ribosomal protein L13 pseudogene 5
SETD6 SET domain containing 6
SHPK sedoheptulokinase
SLC38A10 solute carrier family 38, member 10
SLIT2 slit homolog 2 (Drosophila)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOWAHC sosondowah ankyrin repeat domain family member C
SOX12 SRY (sex determining region Y)-box 12
STARD5 StAR-related lipid transfer (START) domain containing 5
SYNGR3 synaptogyrin 3
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TBX19 T-box 19
TEP1 telomerase-associated protein 1
TMEM104 transmembrane protein 104
TMEM53 transmembrane protein 53
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TTC33 tetratricopeptide repeat domain 33
TUBA3D tubulin, alpha 3d
TUBG2 tubulin, gamma 2
USP36 ubiquitin specific peptidase 36
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VEZT vezatin, adherens junctions transmembrane protein
YIPF3 Yip1 domain family, member 3
ZBTB38 zinc finger and BTB domain containing 38
ZDHHC11 zinc finger, DHHC-type containing 11
ZFP69B ZFP69 zinc finger protein B
ZNF480 zinc finger protein 480
ZNF510 zinc finger protein 510
ZNF516 zinc finger protein 516
ZNF696 zinc finger protein 696
ZNF770 zinc finger protein 770
ZNF84 zinc finger protein 84