Prestwick-1084-6125 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the Prestwick-1084-6125 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACTL8 actin-like 8
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
ANK2 ankyrin 2, neuronal
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
APOC1 apolipoprotein C-I
APOE apolipoprotein E
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARR3 arrestin 3, retinal (X-arrestin)
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BIN1 bridging integrator 1
BPHL biphenyl hydrolase-like (serine hydrolase)
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CAV2 caveolin 2
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CD226 CD226 molecule
CD28 CD28 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CLUL1 clusterin-like 1 (retinal)
CPN2 carboxypeptidase N, polypeptide 2
CRYAA crystallin, alpha A
CSPG4 chondroitin sulfate proteoglycan 4
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DEFB1 defensin, beta 1
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DOCK1 dedicator of cytokinesis 1
DOCK6 dedicator of cytokinesis 6
DOCK9 dedicator of cytokinesis 9
DUSP7 dual specificity phosphatase 7
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EXTL3 exostosin-like glycosyltransferase 3
GH1 growth hormone 1
GNRH2 gonadotropin-releasing hormone 2
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRIA3 glutamate receptor, ionotropic, AMPA 3
GUCY2F guanylate cyclase 2F, retinal
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HIST1H2AK histone cluster 1, H2ak
HIST1H2BJ histone cluster 1, H2bj
HIST2H2AA3 histone cluster 2, H2aa3
HOXB5 homeobox B5
HRASLS2 HRAS-like suppressor 2
HRG histidine-rich glycoprotein
ICOSLG inducible T-cell co-stimulator ligand
IFNG interferon, gamma
IFT27 intraflagellar transport 27
IL13 interleukin 13
IL20RA interleukin 20 receptor, alpha
JADE2 jade family PHD finger 2
KLK1 kallikrein 1
KRT8P12 keratin 8 pseudogene 12
LAMA5 laminin, alpha 5
LAMB4 laminin, beta 4
LINC00574 long intergenic non-protein coding RNA 574
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAN1A2 mannosidase, alpha, class 1A, member 2
MAPK8 mitogen-activated protein kinase 8
MC3R melanocortin 3 receptor
MLH3 mutL homolog 3
MMP19 matrix metallopeptidase 19
MOXD1 monooxygenase, DBH-like 1
MTMR3 myotubularin related protein 3
MXD4 MAX dimerization protein 4
MYL10 myosin, light chain 10, regulatory
NAG18 NAG18 mRNA
NES nestin
NRCAM neuronal cell adhesion molecule
OLFML2B olfactomedin-like 2B
PDE4DIP phosphodiesterase 4D interacting protein
PDE7B phosphodiesterase 7B
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PLXDC1 plexin domain containing 1
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKCH protein kinase C, eta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RARG retinoic acid receptor, gamma
RELN reelin
RGS4 regulator of G-protein signaling 4
RIMS3 regulating synaptic membrane exocytosis 3
SCARA3 scavenger receptor class A, member 3
SH2D1A SH2 domain containing 1A
SH3D21 SH3 domain containing 21
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC48A1 solute carrier family 48 (heme transporter), member 1
SPHK2 sphingosine kinase 2
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPRR1A small proline-rich protein 1A
SV2B synaptic vesicle glycoprotein 2B
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TG thyroglobulin
TMC7 transmembrane channel-like 7
TMCC1 transmembrane and coiled-coil domain family 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TSHR thyroid stimulating hormone receptor
ZNF385D zinc finger protein 385D

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACOX2 acyl-CoA oxidase 2, branched chain
ACPP acid phosphatase, prostate
ANKFY1 ankyrin repeat and FYVE domain containing 1
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
ASGR2 asialoglycoprotein receptor 2
ASPN asporin
BACE1 beta-site APP-cleaving enzyme 1
BGLAP bone gamma-carboxyglutamate (gla) protein
C4ORF29 chromosome 4 open reading frame 29
C9ORF9 chromosome 9 open reading frame 9
CAMKMT calmodulin-lysine N-methyltransferase
CBX7 chromobox homolog 7
CDR2L cerebellar degeneration-related protein 2-like
CEP72 centrosomal protein 72kDa
CHM choroideremia (Rab escort protein 1)
CHMP7 charged multivesicular body protein 7
CLEC4E C-type lectin domain family 4, member E
CRABP2 cellular retinoic acid binding protein 2
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTSG cathepsin G
CTSO cathepsin O
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DCAF17 DDB1 and CUL4 associated factor 17
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
ELP6 elongator acetyltransferase complex subunit 6
ENO2 enolase 2 (gamma, neuronal)
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM50B family with sequence similarity 50, member B
FAM86C1 family with sequence similarity 86, member C1
FEM1C fem-1 homolog c (C. elegans)
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GEMIN8 gem (nuclear organelle) associated protein 8
GK3P glycerol kinase 3 pseudogene
GPX2 glutathione peroxidase 2
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HCAR3 hydroxycarboxylic acid receptor 3
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H3H histone cluster 1, H3h
HIST1H4A histone cluster 1, H4a
HP haptoglobin
HYAL2 hyaluronoglucosaminidase 2
HYAL3 hyaluronoglucosaminidase 3
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IDI2-AS1 IDI2 antisense RNA 1
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KIF17 kinesin family member 17
KIFC1 kinesin family member C1
LIG4 ligase IV, DNA, ATP-dependent
LOC730101 uncharacterized LOC730101
LRRK1 leucine-rich repeat kinase 1
MAGEF1 melanoma antigen family F1
MDM4 MDM4, p53 regulator
MTERF4 mitochondrial transcription termination factor 4
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOD2 nucleotide-binding oligomerization domain containing 2
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NSUN6 NOP2/Sun domain family, member 6
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PARP12 poly (ADP-ribose) polymerase family, member 12
PDGFD platelet derived growth factor D
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PPARG peroxisome proliferator-activated receptor gamma
PYGB phosphorylase, glycogen; brain
RAB23 RAB23, member RAS oncogene family
RNF144A ring finger protein 144A
RPL13P5 ribosomal protein L13 pseudogene 5
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE3 signal peptide, CUB domain, EGF-like 3
SCYL2 SCY1-like 2 (S. cerevisiae)
SERGEF secretion regulating guanine nucleotide exchange factor
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SGCE sarcoglycan, epsilon
SIGLEC9 sialic acid binding Ig-like lectin 9
SNX16 sorting nexin 16
SPATA20 spermatogenesis associated 20
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAS2R10 taste receptor, type 2, member 10
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM242 transmembrane protein 242
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TSPAN13 tetraspanin 13
TTC26 tetratricopeptide repeat domain 26
WASF3 WAS protein family, member 3
WDR62 WD repeat domain 62
YY2 YY2 transcription factor
ZBTB22 zinc finger and BTB domain containing 22
ZMAT5 zinc finger, matrin-type 5
ZNF10 zinc finger protein 10
ZNF276 zinc finger protein 276
ZNF345 zinc finger protein 345
ZNF426 zinc finger protein 426
ZNF480 zinc finger protein 480