Prestwick-1083-6357 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the Prestwick-1083-6357 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY6 adenylate cyclase 6
AGFG1 ArfGAP with FG repeats 1
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ALDOB aldolase B, fructose-bisphosphate
ARHGAP26 Rho GTPase activating protein 26
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
CAV2 caveolin 2
CCDC85B coiled-coil domain containing 85B
CD82 CD82 molecule
CDK3 cyclin-dependent kinase 3
CDON cell adhesion associated, oncogene regulated
CIB2 calcium and integrin binding family member 2
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
COL1A1 collagen, type I, alpha 1
CREB3L1 cAMP responsive element binding protein 3-like 1
CUZD1 CUB and zona pellucida-like domains 1
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DNAH17 dynein, axonemal, heavy chain 17
DTX3 deltex 3, E3 ubiquitin ligase
DVL2 dishevelled segment polarity protein 2
EDIL3 EGF-like repeats and discoidin I-like domains 3
EGFR epidermal growth factor receptor
EIF1 eukaryotic translation initiation factor 1
EML2 echinoderm microtubule associated protein like 2
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ESR1 estrogen receptor 1
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FAM63A family with sequence similarity 63, member A
FGL1 fibrinogen-like 1
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FRYL FRY-like
GAL3ST4 galactose-3-O-sulfotransferase 4
GOLGA2 golgin A2
GPR107 G protein-coupled receptor 107
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HOXC10 homeobox C10
HPS1 Hermansky-Pudlak syndrome 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL33 interleukin 33
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
KCTD13 potassium channel tetramerization domain containing 13
KDM4C lysine (K)-specific demethylase 4C
KLHL25 kelch-like family member 25
LIG4 ligase IV, DNA, ATP-dependent
LMO7 LIM domain 7
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MED14 mediator complex subunit 14
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MINK1 misshapen-like kinase 1
NCKAP1 NCK-associated protein 1
NEK11 NIMA-related kinase 11
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFYA nuclear transcription factor Y, alpha
NIPAL2 NIPA-like domain containing 2
NOX1 NADPH oxidase 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PAOX polyamine oxidase (exo-N4-amino)
PLD2 phospholipase D2
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PRAMEF11 PRAME family member 11
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RNF19B ring finger protein 19B
RPP25 ribonuclease P/MRP 25kDa subunit
SBNO2 strawberry notch homolog 2 (Drosophila)
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SETD1A SET domain containing 1A
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SMAD7 SMAD family member 7
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SNORA21 small nucleolar RNA, H/ACA box 21
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRCAP Snf2-related CREBBP activator protein
SRSF1 serine/arginine-rich splicing factor 1
SRSF7 serine/arginine-rich splicing factor 7
STBD1 starch binding domain 1
STK17B serine/threonine kinase 17b
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBL1Y transducin (beta)-like 1, Y-linked
TBL2 transducin (beta)-like 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TSC22D2 TSC22 domain family, member 2
UNC119 unc-119 homolog (C. elegans)
USB1 U6 snRNA biogenesis 1
VARS valyl-tRNA synthetase
WDR1 WD repeat domain 1
WWOX WW domain containing oxidoreductase
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZBTB22 zinc finger and BTB domain containing 22
ZFP30 ZFP30 zinc finger protein
ZMYM2 zinc finger, MYM-type 2
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ACIN1 apoptotic chromatin condensation inducer 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BNC1 basonuclin 1
BTF3P12 basic transcription factor 3 pseudogene 12
C1ORF115 chromosome 1 open reading frame 115
CAMTA2 calmodulin binding transcription activator 2
CCDC106 coiled-coil domain containing 106
CCDC9 coiled-coil domain containing 9
CCNJ cyclin J
CCNL2 cyclin L2
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CENPT centromere protein T
CHMP6 charged multivesicular body protein 6
CLEC2B C-type lectin domain family 2, member B
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CPEB1 cytoplasmic polyadenylation element binding protein 1
CTC1 CTS telomere maintenance complex component 1
CTSF cathepsin F
CXCL3 chemokine (C-X-C motif) ligand 3
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DDN dendrin
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
EGF epidermal growth factor
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ETNK2 ethanolamine kinase 2
FADS2 fatty acid desaturase 2
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXL7 F-box and leucine-rich repeat protein 7
FPGS folylpolyglutamate synthase
FUZ fuzzy planar cell polarity protein
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GMEB1 glucocorticoid modulatory element binding protein 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPHN gephyrin
HDAC7 histone deacetylase 7
HDAC9 histone deacetylase 9
HOXA6 homeobox A6
HOXC8 homeobox C8
HS1BP3 HCLS1 binding protein 3
IDI2-AS1 IDI2 antisense RNA 1
ITGA10 integrin, alpha 10
KRT15 keratin 15, type I
LINC00341 long intergenic non-protein coding RNA 341
LSR lipolysis stimulated lipoprotein receptor
MAGEH1 melanoma antigen family H1
MKS1 Meckel syndrome, type 1
MTCH2 mitochondrial carrier 2
MYL5 myosin, light chain 5, regulatory
MYOZ3 myozenin 3
NACA2 nascent polypeptide-associated complex alpha subunit 2
NBEAL2 neurobeachin-like 2
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OVGP1 oviductal glycoprotein 1, 120kDa
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PC pyruvate carboxylase
PCSK7 proprotein convertase subtilisin/kexin type 7
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDE12 phosphodiesterase 12
PEX26 peroxisomal biogenesis factor 26
PIEZO1 piezo-type mechanosensitive ion channel component 1
POMT2 protein-O-mannosyltransferase 2
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPL periplakin
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PRPH peripherin
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAD54L2 RAD54-like 2 (S. cerevisiae)
SCG2 secretogranin II
SLC46A3 solute carrier family 46, member 3
SMA4 glucuronidase, beta pseudogene
SPAG4 sperm associated antigen 4
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
TAOK1 TAO kinase 1
TEAD4 TEA domain family member 4
TIGD6 tigger transposable element derived 6
TM7SF2 transmembrane 7 superfamily member 2
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM57 transmembrane protein 57
TRAPPC13 trafficking protein particle complex 13
TRIM45 tripartite motif containing 45
TSPAN1 tetraspanin 1
VEGFB vascular endothelial growth factor B
ZNF177 zinc finger protein 177
ZNF254 zinc finger protein 254
ZNF408 zinc finger protein 408
ZNF532 zinc finger protein 532
ZNF574 zinc finger protein 574
ZNF767P zinc finger family member 767, pseudogene
ZNF862 zinc finger protein 862