Prestwick-1083-2976 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the Prestwick-1083-2976 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACACB acetyl-CoA carboxylase beta
ADGRE1 adhesion G protein-coupled receptor E1
ADRBK1 adrenergic, beta, receptor kinase 1
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AHDC1 AT hook, DNA binding motif, containing 1
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
BTF3P11 basic transcription factor 3 pseudogene 11
BTG3 BTG family, member 3
C1ORF105 chromosome 1 open reading frame 105
C3ORF36 chromosome 3 open reading frame 36
CAPN3 calpain 3, (p94)
CAPN9 calpain 9
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV2 caveolin 2
CDC25C cell division cycle 25C
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CRAT carnitine O-acetyltransferase
CRTC1 CREB regulated transcription coactivator 1
DMWD dystrophia myotonica, WD repeat containing
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EPHB4 EPH receptor B4
EXOC7 exocyst complex component 7
FGFBP1 fibroblast growth factor binding protein 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GATA2 GATA binding protein 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GRM7 glutamate receptor, metabotropic 7
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIST1H2AI histone cluster 1, H2ai
HNF1A HNF1 homeobox A
HOXA4 homeobox A4
HOXC8 homeobox C8
HYAL2 hyaluronoglucosaminidase 2
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IL2 interleukin 2
INO80D INO80 complex subunit D
ITGB4 integrin, beta 4
ITPKC inositol-trisphosphate 3-kinase C
KIAA1109 KIAA1109
KIF1A kinesin family member 1A
KLHL22 kelch-like family member 22
KRT23 keratin 23, type I
LAMC2 laminin, gamma 2
LMNA lamin A/C
LRRC15 leucine rich repeat containing 15
MEFV Mediterranean fever
MLPH melanophilin
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MTA1 metastasis associated 1
MUC3B mucin 3B, cell surface associated
NR2E3 nuclear receptor subfamily 2, group E, member 3
NT5DC3 5'-nucleotidase domain containing 3
NUDCD3 NudC domain containing 3
PADI2 peptidyl arginine deiminase, type II
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PAX3 paired box 3
PCGF2 polycomb group ring finger 2
PDE12 phosphodiesterase 12
PDLIM2 PDZ and LIM domain 2 (mystique)
PIDD1 p53-induced death domain protein 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLCD1 phospholipase C, delta 1
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PODNL1 podocan-like 1
PTCRA pre T-cell antigen receptor alpha
PTEN phosphatase and tensin homolog
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RASAL2 RAS protein activator like 2
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SIX3 SIX homeobox 3
SMTN smoothelin
SOX12 SRY (sex determining region Y)-box 12
SPTB spectrin, beta, erythrocytic
SRCAP Snf2-related CREBBP activator protein
SRPX2 sushi-repeat containing protein, X-linked 2
STXBP6 syntaxin binding protein 6 (amisyn)
TBX5 T-box 5
TFF2 trefoil factor 2
TGFA transforming growth factor, alpha
TJAP1 tight junction associated protein 1 (peripheral)
TMEM134 transmembrane protein 134
TRIM29 tripartite motif containing 29
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)
UROD uroporphyrinogen decarboxylase
WNT16 wingless-type MMTV integration site family, member 16
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZNF324 zinc finger protein 324
ZNF710 zinc finger protein 710
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ACVR2B activin A receptor, type IIB
AKTIP AKT interacting protein
ANKRD55 ankyrin repeat domain 55
AOAH acyloxyacyl hydrolase (neutrophil)
ARRB1 arrestin, beta 1
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASB13 ankyrin repeat and SOCS box containing 13
ATAD5 ATPase family, AAA domain containing 5
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BORA bora, aurora kinase A activator
C4ORF29 chromosome 4 open reading frame 29
CAPRIN2 caprin family member 2
CBY1 chibby homolog 1 (Drosophila)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CEL carboxyl ester lipase
CEP97 centrosomal protein 97kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CHM choroideremia (Rab escort protein 1)
CHML choroideremia-like (Rab escort protein 2)
CHMP7 charged multivesicular body protein 7
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DDA1 DET1 and DDB1 associated 1
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DNA2 DNA replication helicase/nuclease 2
DNAAF2 dynein, axonemal, assembly factor 2
DNMBP dynamin binding protein
DTWD1 DTW domain containing 1
E4F1 E4F transcription factor 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EMD emerin
EXOC5 exocyst complex component 5
FAM179B family with sequence similarity 179, member B
FKBPL FK506 binding protein like
GCLM glutamate-cysteine ligase, modifier subunit
HHLA3 HERV-H LTR-associating 3
HK1 hexokinase 1
HLA-DMA major histocompatibility complex, class II, DM alpha
HMGB3 high mobility group box 3
HRAS Harvey rat sarcoma viral oncogene homolog
HRSP12 heat-responsive protein 12
HYOU1 hypoxia up-regulated 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IKZF5 IKAROS family zinc finger 5 (Pegasus)
KCTD20 potassium channel tetramerization domain containing 20
KDM7A lysine (K)-specific demethylase 7A
KIF18B kinesin family member 18B
KRCC1 lysine-rich coiled-coil 1
LINS lines homolog (Drosophila)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCM9 minichromosome maintenance complex component 9
MECR mitochondrial trans-2-enoyl-CoA reductase
MED9 mediator complex subunit 9
NLRX1 NLR family member X1
NMD3 NMD3 ribosome export adaptor
NME6 NME/NM23 nucleoside diphosphate kinase 6
NPIPB3 nuclear pore complex interacting protein family, member B3
NQO2 NAD(P)H dehydrogenase, quinone 2
OTUD3 OTU deubiquitinase 3
PCTP phosphatidylcholine transfer protein
PECR peroxisomal trans-2-enoyl-CoA reductase
PNOC prepronociceptin
PSAT1 phosphoserine aminotransferase 1
QDPR quinoid dihydropteridine reductase
R3HCC1L R3H domain and coiled-coil containing 1-like
RBM4B RNA binding motif protein 4B
RBM7 RNA binding motif protein 7
RNF113A ring finger protein 113A
SEC24B SEC24 family member B
SERINC5 serine incorporator 5
SP1 Sp1 transcription factor
SSFA2 sperm specific antigen 2
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
SURF2 surfeit 2
TARBP2 TAR (HIV-1) RNA binding protein 2
TEP1 telomerase-associated protein 1
TET3 tet methylcytosine dioxygenase 3
THOC1 THO complex 1
TMEM106B transmembrane protein 106B
TMEM242 transmembrane protein 242
TMOD3 tropomodulin 3 (ubiquitous)
TPRA1 transmembrane protein, adipocyte asscociated 1
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM36 tripartite motif containing 36
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae)
TSPYL2 TSPY-like 2
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WDR33 WD repeat domain 33
YY2 YY2 transcription factor
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZDHHC24 zinc finger, DHHC-type containing 24
ZMAT3 zinc finger, matrin-type 3
ZMPSTE24 zinc metallopeptidase STE24
ZNF354A zinc finger protein 354A
ZNF573 zinc finger protein 573