Prestwick-1080-4354 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the Prestwick-1080-4354 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACE2 angiotensin I converting enzyme 2
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADAM12 ADAM metallopeptidase domain 12
ALDOB aldolase B, fructose-bisphosphate
ALOXE3 arachidonate lipoxygenase 3
ASMT acetylserotonin O-methyltransferase
ASPH aspartate beta-hydroxylase
ATXN7L1 ataxin 7-like 1
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BICC1 BicC family RNA binding protein 1
BTF3P11 basic transcription factor 3 pseudogene 11
BTNL8 butyrophilin-like 8
C17ORF53 chromosome 17 open reading frame 53
CDC14B cell division cycle 14B
CEP135 centrosomal protein 135kDa
CEP41 centrosomal protein 41kDa
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CLDN14 claudin 14
COL7A1 collagen, type VII, alpha 1
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
EFS embryonal Fyn-associated substrate
EGF epidermal growth factor
EN2 engrailed homeobox 2
FBXL18 F-box and leucine-rich repeat protein 18
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGF16 fibroblast growth factor 16
FRMD1 FERM domain containing 1
FRMD8 FERM domain containing 8
FYB FYN binding protein
GRM6 glutamate receptor, metabotropic 6
HCLS1 hematopoietic cell-specific Lyn substrate 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
IFI44 interferon-induced protein 44
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INPP5J inositol polyphosphate-5-phosphatase J
IRF8 interferon regulatory factor 8
JPH3 junctophilin 3
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KLK3 kallikrein-related peptidase 3
KRT19P2 keratin 19 pseudogene 2
KRTAP2-4 keratin associated protein 2-4
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LIMK1 LIM domain kinase 1
LPAR4 lysophosphatidic acid receptor 4
LRRC75B leucine rich repeat containing 75B
LTC4S leukotriene C4 synthase
LYZL6 lysozyme-like 6
MAPK8 mitogen-activated protein kinase 8
MBD2 methyl-CpG binding domain protein 2
MIER2 mesoderm induction early response 1, family member 2
MRAS muscle RAS oncogene homolog
MUC3B mucin 3B, cell surface associated
MYRIP myosin VIIA and Rab interacting protein
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NRG1 neuregulin 1
OLFM4 olfactomedin 4
OR10J1 olfactory receptor, family 10, subfamily J, member 1
OR1E1 olfactory receptor, family 1, subfamily E, member 1
PCDHGA8 protocadherin gamma subfamily A, 8
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PML promyelocytic leukemia
PRLH prolactin releasing hormone
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
RAB3B RAB3B, member RAS oncogene family
RBM17 RNA binding motif protein 17
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
SCRG1 stimulator of chondrogenesis 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIM2 single-minded family bHLH transcription factor 2
SLA Src-like-adaptor
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC17A4 solute carrier family 17, member 4
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC30A10 solute carrier family 30, member 10
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SYNE1 spectrin repeat containing, nuclear envelope 1
TAGLN3 transgelin 3
TLDC1 TBC/LysM-associated domain containing 1
TM6SF2 transmembrane 6 superfamily member 2
TMLHE trimethyllysine hydroxylase, epsilon
TNIK TRAF2 and NCK interacting kinase
TP63 tumor protein p63
TPSAB1 tryptase alpha/beta 1
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM22 tripartite motif containing 22
TRIM31 tripartite motif containing 31
UNC13A unc-13 homolog A (C. elegans)
UTS2 urotensin 2
VCAN versican
ZNF235 zinc finger protein 235
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM15 ADAM metallopeptidase domain 15
AKIP1 A kinase (PRKA) interacting protein 1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
BCAS4 breast carcinoma amplified sequence 4
BOLA1 bolA family member 1
C14ORF79 chromosome 14 open reading frame 79
CAMK1 calcium/calmodulin-dependent protein kinase I
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBX8 chromobox homolog 8
CCNO cyclin O
CDK20 cyclin-dependent kinase 20
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHKB choline kinase beta
CLDN1 claudin 1
CLEC16A C-type lectin domain family 16, member A
CORO7 coronin 7
CRIP2 cysteine-rich protein 2
CST3 cystatin C
CTC1 CTS telomere maintenance complex component 1
CTSD cathepsin D
CUEDC1 CUE domain containing 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
EVPL envoplakin
EXO5 exonuclease 5
FBRS fibrosin
FBXL6 F-box and leucine-rich repeat protein 6
FLT4 fms-related tyrosine kinase 4
FSTL3 follistatin-like 3 (secreted glycoprotein)
GMEB1 glucocorticoid modulatory element binding protein 1
GMPR guanosine monophosphate reductase
GPR143 G protein-coupled receptor 143
GPS1 G protein pathway suppressor 1
GRAMD1C GRAM domain containing 1C
HDAC5 histone deacetylase 5
HIST1H2BJ histone cluster 1, H2bj
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IL17RA interleukin 17 receptor A
KIAA0319L KIAA0319-like
LIN7A lin-7 homolog A (C. elegans)
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LY6E lymphocyte antigen 6 complex, locus E
MALL mal, T-cell differentiation protein-like
METRN meteorin, glial cell differentiation regulator
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MOGS mannosyl-oligosaccharide glucosidase
MPG N-methylpurine-DNA glycosylase
MVD mevalonate (diphospho) decarboxylase
NBEAL2 neurobeachin-like 2
NES nestin
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPDC1 neural proliferation, differentiation and control, 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NXPH4 neurexophilin 4
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OSGIN1 oxidative stress induced growth inhibitor 1
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PECR peroxisomal trans-2-enoyl-CoA reductase
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PORCN porcupine homolog (Drosophila)
PRR4 proline rich 4 (lacrimal)
PTPRU protein tyrosine phosphatase, receptor type, U
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3D RAB3D, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RNF121 ring finger protein 121
RNF208 ring finger protein 208
RPP25 ribonuclease P/MRP 25kDa subunit
RRAGB Ras-related GTP binding B
SCPEP1 serine carboxypeptidase 1
SH3GLB2 SH3-domain GRB2-like endophilin B2
SKI SKI proto-oncogene
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SPAG4 sperm associated antigen 4
STARD3 StAR-related lipid transfer (START) domain containing 3
THAP7 THAP domain containing 7
THBS3 thrombospondin 3
TMEM53 transmembrane protein 53
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPST2 tyrosylprotein sulfotransferase 2
TRIM25 tripartite motif containing 25
TSPO translocator protein (18kDa)
UNC93B1 unc-93 homolog B1 (C. elegans)
UROS uroporphyrinogen III synthase
VARS valyl-tRNA synthetase
VIPR1 vasoactive intestinal peptide receptor 1
ZBTB48 zinc finger and BTB domain containing 48
ZC3H3 zinc finger CCCH-type containing 3
ZNF282 zinc finger protein 282
ZNF74 zinc finger protein 74
ZNF747 zinc finger protein 747