Pregnancy Complications Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

192 genes associated with the Pregnancy Complications phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACE angiotensin I converting enzyme
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM33 ADAM metallopeptidase domain 33
ADGRL3 adhesion G protein-coupled receptor L3
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR2 adiponectin receptor 2
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANGPT1 angiopoietin 1
ANXA5 annexin A5
AOAH acyloxyacyl hydrolase (neutrophil)
APOA5 apolipoprotein A-V
APOE apolipoprotein E
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CAPN10 calpain 10
CAT catalase
CBS cystathionine-beta-synthase
CCL11 chemokine (C-C motif) ligand 11
CCL3L1 chemokine (C-C motif) ligand 3-like 1
CCL4L2 chemokine (C-C motif) ligand 4-like 2
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
COMT catechol-O-methyltransferase
CPB2 carboxypeptidase B2 (plasma)
CRHBP corticotropin releasing hormone binding protein
CRHR1 corticotropin releasing hormone receptor 1
CRP C-reactive protein, pentraxin-related
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNA3 catenin (cadherin-associated protein), alpha 3
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DAP3 death associated protein 3
DHFR dihydrofolate reductase
DPP10 dipeptidyl-peptidase 10 (non-functional)
DRD2 dopamine receptor D2
DRD4 dopamine receptor D4
EDIL3 EGF-like repeats and discoidin I-like domains 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERAP1 endoplasmic reticulum aminopeptidase 1
ERAP2 endoplasmic reticulum aminopeptidase 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FGB fibrinogen beta chain
FGF19 fibroblast growth factor 19
FKBP5 FK506 binding protein 5
FTO fat mass and obesity associated
FYN FYN proto-oncogene, Src family tyrosine kinase
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6
GCK glucokinase (hexokinase 4)
GLO1 glyoxalase I
GLRX glutaredoxin (thioltransferase)
GPX1 glutathione peroxidase 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HAMP hepcidin antimicrobial peptide
HAVCR1 hepatitis A virus cellular receptor 1
HBA1 hemoglobin, alpha 1
HFE hemochromatosis
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HLA-G major histocompatibility complex, class I, G
HMGA2 high mobility group AT-hook 2
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic
HTR3D 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGF2 insulin-like growth factor 2
IL10 interleukin 10
IL13 interleukin 13
IL16 interleukin 16
IL1RN interleukin 1 receptor antagonist
IL3 interleukin 3
IL33 interleukin 33
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL6 interleukin 6
JAK2 Janus kinase 2
KDR kinase insert domain receptor
KHDC3L KH domain containing 3-like, subcortical maternal complex member
KRT18P16 keratin 18 pseudogene 16
KRT18P42 keratin 18 pseudogene 42
LEP leptin
LEPR leptin receptor
LNPEP leucyl/cystinyl aminopeptidase
LPL lipoprotein lipase
LTA lymphotoxin alpha
LVRN laeverin
MAOA monoamine oxidase A
MBL2 mannose-binding lectin (protein C) 2, soluble
MEFV Mediterranean fever
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTNR1B melatonin receptor 1B
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NLRP3 NLR family, pyrin domain containing 3
NLRP7 NLR family, pyrin domain containing 7
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OPN3 opsin 3
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PON1 paraoxonase 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PTGDR prostaglandin D2 receptor (DP)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRD protein tyrosine phosphatase, receptor type, D
PTPRE protein tyrosine phosphatase, receptor type, E
PWAR1 Prader Willi/Angelman region RNA 1
RAD50 RAD50 homolog (S. cerevisiae)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RETN resistin
RFC1 replication factor C (activator 1) 1, 145kDa
RIOK2 RIO kinase 2
SBNO1 strawberry notch homolog 1 (Drosophila)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SOD2 superoxide dismutase 2, mitochondrial
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK11 serine/threonine kinase 11
TACR1 tachykinin receptor 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX21 T-box 21
TBXA2R thromboxane A2 receptor
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UTS2 urotensin 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
ZFR zinc finger RNA binding protein