Precancerous Conditions Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
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Genes

156 genes associated with the Precancerous Conditions phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACE angiotensin I converting enzyme
AGO1 argonaute RISC catalytic component 1
AGO2 argonaute RISC catalytic component 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APC adenomatous polyposis coli
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AR androgen receptor
ARG1 arginase 1
AS3MT arsenite methyltransferase
ATM ATM serine/threonine kinase
AURKA aurora kinase A
BMPR1A bone morphogenetic protein receptor, type IA
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CAT catalase
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CCNH cyclin H
CCR2 chemokine (C-C motif) receptor 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHEK2 checkpoint kinase 2
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
CST3 cystatin C
CXCL8 chemokine (C-X-C motif) ligand 8
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DGCR8 DGCR8 microprocessor complex subunit
DICER1 dicer 1, ribonuclease type III
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EPHB2 EPH receptor B2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC2 excision repair cross-complementation group 2
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ERCC6 excision repair cross-complementation group 6
ESR1 estrogen receptor 1
F5 coagulation factor V (proaccelerin, labile factor)
FAM212B family with sequence similarity 212, member B
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FUT2 fucosyltransferase 2 (secretor status included)
GEMIN4 gem (nuclear organelle) associated protein 4
GSTM1 glutathione S-transferase mu 1
GSTO1 glutathione S-transferase omega 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPA2 heat shock 70kDa protein 2
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IL10 interleukin 10
IL18 interleukin 18
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
KRAS Kirsten rat sarcoma viral oncogene homolog
LEPR leptin receptor
LIG4 ligase IV, DNA, ATP-dependent
LOX lysyl oxidase
LTA lymphotoxin alpha
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MGMT O-6-methylguanine-DNA methyltransferase
MIR100 microRNA 100
MIR124-1 microRNA 124-1
MIR196A2 microRNA 196a-2
MIR219A1 microRNA 219a-1
MIR26A1 microRNA 26a-1
MIR30A microRNA 30a
MIR30C1 microRNA 30c-1
MIR373 microRNA 373
MIR423 microRNA 423
MIR492 microRNA 492
MIR604 microRNA 604
MIR608 microRNA 608
MIRLET7A1 microRNA let-7a-1
MIRLET7F1 microRNA let-7f-1
MMP7 matrix metallopeptidase 7
MMP8 matrix metallopeptidase 8
MPO myeloperoxidase
MSR1 macrophage scavenger receptor 1
MTAP methylthioadenosine phosphorylase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC1 mucin 1, cell surface associated
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC6 mucin 6, oligomeric mucus/gel-forming
MYO9B myosin IXB
NBN nibrin
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
ODC1 ornithine decarboxylase 1
OGG1 8-oxoguanine DNA glycosylase
PARP1 poly (ADP-ribose) polymerase 1
PDE11A phosphodiesterase 11A
PGC progastricsin (pepsinogen C)
PIF1 PIF1 5'-to-3' DNA helicase
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRDX3 peroxiredoxin 3
PSCA prostate stem cell antigen
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD51 RAD51 recombinase
RAG1 recombination activating gene 1
RAN RAN, member RAS oncogene family
RBL1 retinoblastoma-like 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF43 ring finger protein 43
RPS19 ribosomal protein S19
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SMAD4 SMAD family member 4
SOD2 superoxide dismutase 2, mitochondrial
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TELO2 telomere maintenance 2
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TP53 tumor protein p53
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
XAF1 XIAP associated factor 1
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)