Pre-Eclampsia Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy. (Human Disease Ontology, DOID_10591)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D011225
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Genes

376 genes/proteins associated with the disease Pre-Eclampsia from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.88009
PEE2 Preeclampsia/eclampsia 2 2.88009
INHBA inhibin, beta A 2.88009
NOS3 nitric oxide synthase 3 (endothelial cell) 2.88009
ANXA5 annexin A5 2.88009
DDAH2 dimethylarginine dimethylaminohydrolase 2 2.88009
FLT1 fms-related tyrosine kinase 1 2.88009
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.88009
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 2.88009
SCNN1A sodium channel, non voltage gated 1 alpha subunit 2.88009
PEE3 Preeclampsia/eclampsia 3 2.88009
PEE1 preeclampsia/eclampsia 1 2.88009
ACE angiotensin I converting enzyme 2.88009
HMOX1 heme oxygenase 1 2.88009
STOX1 storkhead box 1 2.88009
EDN1 endothelin 1 2.88009
CP ceruloplasmin (ferroxidase) 2.88009
COL1A1 collagen, type I, alpha 1 1.7872
TGFB1 transforming growth factor, beta 1 1.76966
TNF tumor necrosis factor 1.73999
MMP2 matrix metallopeptidase 2 1.71708
BCL2 B-cell CLL/lymphoma 2 1.70056
FOS FBJ murine osteosarcoma viral oncogene homolog 1.67868
EGR1 early growth response 1 1.67398
CCL2 chemokine (C-C motif) ligand 2 1.67159
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.67116
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.65
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.61436
BAX BCL2-associated X protein 1.59826
CXCL8 chemokine (C-X-C motif) ligand 8 1.58491
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.58351
MAPK3 mitogen-activated protein kinase 3 1.58018
JUN jun proto-oncogene 1.57522
MAPK1 mitogen-activated protein kinase 1 1.57066
CRP C-reactive protein, pentraxin-related 1.56681
IL6 interleukin 6 1.56656
ICAM1 intercellular adhesion molecule 1 1.5641
CYBB cytochrome b-245, beta polypeptide 1.56263
IGF1 insulin-like growth factor 1 (somatomedin C) 1.56019
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.55624
NFE2L2 nuclear factor, erythroid 2-like 2 1.55108
CLU clusterin 1.54427
TP53 tumor protein p53 1.5311
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.52987
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.52642
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.51911
HSPB1 heat shock 27kDa protein 1 1.51607
NOS2 nitric oxide synthase 2, inducible 1.51582
CCNE1 cyclin E1 1.50675
NAMPT nicotinamide phosphoribosyltransferase 1.50373
COL1A2 collagen, type I, alpha 2 1.49584
VEGFA vascular endothelial growth factor A 1.48582
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.4817
GSTP1 glutathione S-transferase pi 1 1.47889
EGLN3 egl-9 family hypoxia-inducible factor 3 1.47634
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.47244
PDGFB platelet-derived growth factor beta polypeptide 1.46041
S100A8 S100 calcium binding protein A8 1.45273
MMP1 matrix metallopeptidase 1 1.44899
LEP leptin 1.44463
CXCL2 chemokine (C-X-C motif) ligand 2 1.44166
IL1B interleukin 1, beta 1.43919
APOE apolipoprotein E 1.43837
TXN thioredoxin 1.43401
MME membrane metallo-endopeptidase 1.43293
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.43266
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.42859
GADD45A growth arrest and DNA-damage-inducible, alpha 1.42428
GSR glutathione reductase 1.42374
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.42321
THBD thrombomodulin 1.42238
HSPA1A heat shock 70kDa protein 1A 1.40595
VCAM1 vascular cell adhesion molecule 1 1.40486
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 1.40008
AHR aryl hydrocarbon receptor 1.39841
CAV1 caveolin 1, caveolae protein, 22kDa 1.3903
BCL2L1 BCL2-like 1 1.38863
CCND1 cyclin D1 1.38527
G0S2 G0/G1 switch 2 1.38355
SOD2 superoxide dismutase 2, mitochondrial 1.38015
NOX4 NADPH oxidase 4 1.37676
ARG2 arginase 2 1.37676
IL1A interleukin 1, alpha 1.37217
AQP3 aquaporin 3 (Gill blood group) 1.35734
CREB1 cAMP responsive element binding protein 1 1.35299
GPX1 glutathione peroxidase 1 1.35098
DDIT3 DNA-damage-inducible transcript 3 1.3484
CAT catalase 1.34782
MUC1 mucin 1, cell surface associated 1.34752
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.3388
ALB albumin 1.3385
EGFR epidermal growth factor receptor 1.33346
DAD1 defender against cell death 1 1.33052
CTGF connective tissue growth factor 1.32905
NQO1 NAD(P)H dehydrogenase, quinone 1 1.32905
PPARG peroxisome proliferator-activated receptor gamma 1.32846
SPP1 secreted phosphoprotein 1 1.32756
GLUL glutamate-ammonia ligase 1.32518
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.32369
RND3 Rho family GTPase 3 1.32251
ANXA2 annexin A2 1.31746
AGER advanced glycosylation end product-specific receptor 1.31686
MAPK8 mitogen-activated protein kinase 8 1.31596
EIF5 eukaryotic translation initiation factor 5 1.31387
TCF4 transcription factor 4 1.30819
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.30543
IGF2 insulin-like growth factor 2 1.29936
ADIPOQ adiponectin, C1Q and collagen domain containing 1.29812
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 1.29688
ODC1 ornithine decarboxylase 1 1.29688
STAR steroidogenic acute regulatory protein 1.29533
RB1 retinoblastoma 1 1.28765
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.28579
GSTA1 glutathione S-transferase alpha 1 1.28456
GSTM1 glutathione S-transferase mu 1 1.28058
SOD1 superoxide dismutase 1, soluble 1.28058
CTTN cortactin 1.27689
APP amyloid beta (A4) precursor protein 1.2744
PCNA proliferating cell nuclear antigen 1.27347
PLAUR plasminogen activator, urokinase receptor 1.27193
IGFBP1 insulin-like growth factor binding protein 1 1.26886
CTSB cathepsin B 1.26856
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.26856
HBA1 hemoglobin, alpha 1 1.26825
SP1 Sp1 transcription factor 1.267
FST follistatin 1.26576
ATF4 activating transcription factor 4 1.26545
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.2639
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.26359
FAS Fas cell surface death receptor 1.26329
C3 complement component 3 1.26083
GCLM glutamate-cysteine ligase, modifier subunit 1.25899
HSF1 heat shock transcription factor 1 1.254
MMP3 matrix metallopeptidase 3 1.25307
NT5DC2 5'-nucleotidase domain containing 2 1.25183
ATF3 activating transcription factor 3 1.25028
S100A6 S100 calcium binding protein A6 1.24935
IFNG interferon, gamma 1.24874
WFDC2 WAP four-disulfide core domain 2 1.24812
SPON1 spondin 1, extracellular matrix protein 1.24812
SMAD2 SMAD family member 2 1.24718
KLF4 Kruppel-like factor 4 (gut) 1.24496
GSN gelsolin 1.24496
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.24433
BDNF brain-derived neurotrophic factor 1.23868
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.23806
MGP matrix Gla protein 1.23806
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 1.2368
MMP9 matrix metallopeptidase 9 1.23584
F2 coagulation factor II (thrombin) 1.2352
PPARA peroxisome proliferator-activated receptor alpha 1.23392
PRMT1 protein arginine methyltransferase 1 1.23296
MTF1 metal-regulatory transcription factor 1 1.23296
REN renin 1.23233
MT1A metallothionein 1A 1.2279
CCL11 chemokine (C-C motif) ligand 11 1.22727
MT2A metallothionein 2A 1.22501
IGFBP3 insulin-like growth factor binding protein 3 1.22501
SIRT1 sirtuin 1 1.22209
F2R coagulation factor II (thrombin) receptor 1.2208
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.2208
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 1.21855
PRKCA protein kinase C, alpha 1.2137
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.21239
FOXA2 forkhead box A2 1.21173
TIMP1 TIMP metallopeptidase inhibitor 1 1.20687
S100A9 S100 calcium binding protein A9 1.20229
G6PC glucose-6-phosphatase, catalytic subunit 1.20229
CREBBP CREB binding protein 1.20031
JUND jun D proto-oncogene 1.19835
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.19639
CD36 CD36 molecule (thrombospondin receptor) 1.19607
CCL20 chemokine (C-C motif) ligand 20 1.19445
PON1 paraoxonase 1 1.19345
PTEN phosphatase and tensin homolog 1.19345
APOA1 apolipoprotein A-I 1.19345
PLAT plasminogen activator, tissue 1.19345
G6PD glucose-6-phosphate dehydrogenase 1.19213
THY1 Thy-1 cell surface antigen 1.19179
ECE1 endothelin converting enzyme 1 1.19179
FABP6 fatty acid binding protein 6, ileal 1.18915
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.18685
GJA1 gap junction protein, alpha 1, 43kDa 1.18685
NPPA natriuretic peptide A 1.18456
FGF2 fibroblast growth factor 2 (basic) 1.18326
PRKCB protein kinase C, beta 1.18293
AGTR2 angiotensin II receptor, type 2 1.18293
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 1.17959
TFRC transferrin receptor 1.17926
JCHAIN joining chain of multimeric IgA and IgM 1.17728
PXDN peroxidasin 1.17728
ADM adrenomedullin 1.17563
ARNT aryl hydrocarbon receptor nuclear translocator 1.17563
AQP4 aquaporin 4 1.17366
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 1.17235
TGFA transforming growth factor, alpha 1.17202
CKM creatine kinase, muscle 1.17067
TLR2 toll-like receptor 2 1.16833
GADD45B growth arrest and DNA-damage-inducible, beta 1.16833
FTH1 ferritin, heavy polypeptide 1 1.16833
RPSA ribosomal protein SA 1.16766
DUSP1 dual specificity phosphatase 1 1.167
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.166
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 1.165
IL10 interleukin 10 1.16203
IRS1 insulin receptor substrate 1 1.16137
RETN resistin 1.15967
FKBP4 FK506 binding protein 4, 59kDa 1.15933
COL18A1 collagen, type XVIII, alpha 1 1.15933
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.15661
ESR1 estrogen receptor 1 1.1556
CPM carboxypeptidase M 1.1556
TBX21 T-box 21 1.1556
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.1529
POR P450 (cytochrome) oxidoreductase 1.1529
LHB luteinizing hormone beta polypeptide 1.15156
CXCL10 chemokine (C-X-C motif) ligand 10 1.15156
ELK1 ELK1, member of ETS oncogene family 1.15089
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 1.15089
MPST mercaptopyruvate sulfurtransferase 1.15055
RPA3 replication protein A3, 14kDa 1.15022
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.14919
UGCG UDP-glucose ceramide glucosyltransferase 1.14816
BCAP31 B-cell receptor-associated protein 31 1.1461
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 1.1461
ACTA2 actin, alpha 2, smooth muscle, aorta 1.14575
NME1 NME/NM23 nucleoside diphosphate kinase 1 1.14541
BCL6 B-cell CLL/lymphoma 6 1.14541
NCF1 neutrophil cytosolic factor 1 1.14098
MMP7 matrix metallopeptidase 7 1.1403
SELENBP1 selenium binding protein 1 1.13997
CCL3 chemokine (C-C motif) ligand 3 1.13895
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 1.13758
PRL prolactin 1.13689
GSTA2 glutathione S-transferase alpha 2 1.13586
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.13347
EP300 E1A binding protein p300 1.13245
TRIB3 tribbles pseudokinase 3 1.13143
PIGR polymeric immunoglobulin receptor 1.13075
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.13075
LCN2 lipocalin 2 1.12973
SOCS2 suppressor of cytokine signaling 2 1.12737
CKS2 CDC28 protein kinase regulatory subunit 2 1.12737
ITGA1 integrin, alpha 1 1.12599
CCT7 chaperonin containing TCP1, subunit 7 (eta) 1.12599
CPT1A carnitine palmitoyltransferase 1A (liver) 1.12357
IL6ST interleukin 6 signal transducer 1.12254
FN1 fibronectin 1 1.12254
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.12082
CD14 CD14 molecule 1.12048
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.12048
CD38 CD38 molecule 1.11741
PKP2 plakophilin 2 1.11707
PTPRG protein tyrosine phosphatase, receptor type, G 1.11707
SMO smoothened, frizzled class receptor 1.11707
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 1.11536
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 1.1129
BLNK B-cell linker 1.11255
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 1.11046
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 1.11046
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 1.10838
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.10838
INS insulin 1.10596
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 1.10596
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 1.10424
TSPO translocator protein (18kDa) 1.10353
CD86 CD86 molecule 1.10246
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.10246
TGFB3 transforming growth factor, beta 3 1.1014
CCL5 chemokine (C-C motif) ligand 5 1.10069
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 1.09998
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 1.09892
STAT4 signal transducer and activator of transcription 4 1.09576
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 1.09576
NOS1 nitric oxide synthase 1 (neuronal) 1.09262
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.09083
ERCC1 excision repair cross-complementation group 1 1.09011
IFITM3 interferon induced transmembrane protein 3 1.08797
ALDOA aldolase A, fructose-bisphosphate 1.08762
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.08762
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.0869
HNMT histamine N-methyltransferase 1.08407
B2M beta-2-microglobulin 1.08337
IFRD1 interferon-related developmental regulator 1 1.08337
PRDX6 peroxiredoxin 6 1.08126
RPS27L ribosomal protein S27-like 1.08019
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.07732
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.07696
DIO2 deiodinase, iodothyronine, type II 1.07696
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 1.07696
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.07625
PDPK1 3-phosphoinositide dependent protein kinase 1 1.07625
PDLIM1 PDZ and LIM domain 1 1.07625
HSPE1 heat shock 10kDa protein 1 1.07482
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1.07305
FSHB follicle stimulating hormone, beta polypeptide 1.06917
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 1.06844
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.06771
AQP1 aquaporin 1 (Colton blood group) 1.06661
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 1.06552
SEPW1 selenoprotein W, 1 1.06552
MB myoglobin 1.06552
SAA3P serum amyloid A3 pseudogene 1.06515
USP18 ubiquitin specific peptidase 18 1.06515
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.06515
HSPA8 heat shock 70kDa protein 8 1.06406
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 1.06188
DYNLL1 dynein, light chain, LC8-type 1 1.06188
BMP4 bone morphogenetic protein 4 1.0608
SOD3 superoxide dismutase 3, extracellular 1.0608
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.06044
JUNB jun B proto-oncogene 1.06008
FOXO3 forkhead box O3 1.05864
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 1.05498
ACKR3 atypical chemokine receptor 3 1.05461
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.05349
KLF6 Kruppel-like factor 6 1.05274
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.052
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 1.05089
GUCY1B3 guanylate cyclase 1, soluble, beta 3 1.04794
LMCD1 LIM and cysteine-rich domains 1 1.04794
PDZK1 PDZ domain containing 1 1.04757
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 1.04757
FASLG Fas ligand (TNF superfamily, member 6) 1.04465
CLSTN2 calsyntenin 2 1.04427
KLHL23 kelch-like family member 23 1.04427
CLIC4 chloride intracellular channel 4 1.04427
TP53BP2 tumor protein p53 binding protein 2 1.04427
H3F3A H3 histone, family 3A 1.04427
PAM peptidylglycine alpha-amidating monooxygenase 1.04088
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 1.04088
HNF1A HNF1 homeobox A 1.04088
CALR calreticulin 1.03901
TSC2 tuberous sclerosis 2 1.03789
ARG1 arginase 1 1.03752
HSPH1 heat shock 105kDa/110kDa protein 1 1.03715
PNLIPRP1 pancreatic lipase-related protein 1 1.03678
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.03567
OGG1 8-oxoguanine DNA glycosylase 1.03567
ALOX15 arachidonate 15-lipoxygenase 1.03493
ADAM17 ADAM metallopeptidase domain 17 1.03456
SFTPB surfactant protein B 1.03456
SLC39A8 solute carrier family 39 (zinc transporter), member 8 1.03456
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.03345
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.03235
PKM pyruvate kinase, muscle 1.03159
NMNAT1 nicotinamide nucleotide adenylyltransferase 1 1.03009
TICAM1 toll-like receptor adaptor molecule 1 1.02971
HIPK2 homeodomain interacting protein kinase 2 1.02821
EPO erythropoietin 1.02821
MFGE8 milk fat globule-EGF factor 8 protein 1.02821
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 1.02821
RHOA ras homolog family member A 1.02634
GCLC glutamate-cysteine ligase, catalytic subunit 1.02559
MIR21 microRNA 21 1.02522
BCL3 B-cell CLL/lymphoma 3 1.02522
CYBA cytochrome b-245, alpha polypeptide 1.02485
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 1.02485
HOMER1 homer scaffolding protein 1 1.02485
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.02447
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.02299
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.02299
HSPA1L heat shock 70kDa protein 1-like 1.02262
PPP1R12A protein phosphatase 1, regulatory subunit 12A 1.02188
FASN fatty acid synthase 1.02188
LPL lipoprotein lipase 1.0204
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.0204
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.0189
ACACB acetyl-CoA carboxylase beta 1.0189
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 1.0189
NPPB natriuretic peptide B 1.01776
MTF2 metal response element binding transcription factor 2 1.01663
PRDX1 peroxiredoxin 1 1.01587
IER3 immediate early response 3 1.01212
IL2 interleukin 2 1.01137
MIR369 microRNA 369 1.01062