Pneumonia Gene Set

Dataset HuGE Navigator Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing. (Human Disease Ontology, DOID_552)
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Genes

72 genes associated with the Pneumonia phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AHR aryl hydrocarbon receptor
BLMH bleomycin hydrolase
CAT catalase
CCL5 chemokine (C-C motif) ligand 5
CCR3 chemokine (C-C motif) receptor 3
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CRP C-reactive protein, pentraxin-related
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYSLTR1 cysteinyl leukotriene receptor 1
DUOX1 dual oxidase 1
DUOX2 dual oxidase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FOXI1 forkhead box I1
GCLC glutamate-cysteine ligase, catalytic subunit
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HBB hemoglobin, beta
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IL10 interleukin 10
IL12A interleukin 12A
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL6 interleukin 6
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10
KIFC1 kinesin family member C1
LTA lymphotoxin alpha
MARCO macrophage receptor with collagenous structure
MBL2 mannose-binding lectin (protein C) 2, soluble
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYLK myosin light chain kinase
NAMPT nicotinamide phosphoribosyltransferase
NCF1 neutrophil cytosolic factor 1
NCF2 neutrophil cytosolic factor 2
NCF4 neutrophil cytosolic factor 4, 40kDa
NOS3 nitric oxide synthase 3 (endothelial cell)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPA1 surfactant protein A1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPD surfactant protein D
SOD2 superoxide dismutase 2, mitochondrial
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A